Obsessive-Compulsive Disorder
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Following on from previous work by our group where we showed that early onset anorexia nervosa (AN) and obsessive-compulsive disorder (OCD) shared a common genetic background, the aim of the present study is to assess genetic pleiotropy related to the serotonergic system (SLC6A4, 5HTR2A, 5HTR2C, TPH2, SLC18A1), in a common phenotype such as very-early age of onset.
|
30554102 |
2019 |
Obsessive-Compulsive Disorder
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
The current study set three questions: Firstly, whether the high expressing loci of the SLC6A4 polymorphisms, 5-HTTLPR + rs25531, rs25532 and rs16965628 are associated with family-based (n = 164 trios) and case-control OCD (n = 186, 152, respectively).
|
29102815 |
2018 |
Obsessive-Compulsive Disorder
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
The comparison of serotonin transporter linked polymorphic region (5-HTTLPR) in 102 OCD patients and 223 controls showed an increased L-allele frequency but no difference was observed when rs25531 was included.
|
30121542 |
2018 |
Obsessive-Compulsive Disorder
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Although we did not observe any statistically significant association between the HTR2A gene polymorphisms and OCD or its clinical features, SLC6A4 STin2 polymorphism was significantly more common among OCD patients as compared to health controls.
|
29331882 |
2018 |
Obsessive-Compulsive Disorder
|
0.600 |
Biomarker
|
disease |
BEFREE |
We previously reported that brain-specific diacylglycerol kinase (DGK) δ-knockout (KO) mice showed obsessive-compulsive disorder (OCD)-like behaviors, which were alleviated by a serotonin (5-HT) transporter (SERT) inhibitor.
|
29486157 |
2018 |
Obsessive-Compulsive Disorder
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Although findings to date are mixed, serotonin transporter polymorphism 5-HTTLPR and HTR2A polymorphism rs6311 (or rs6313) are most consistently associated with OCD.
|
28576508 |
2017 |
Obsessive-Compulsive Disorder
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
The frequency of SLa genotype of 5-HTTLPR polymorphism was found to be higher in patients with OCD compared with healthy controls.
|
26986829 |
2016 |
Obsessive-Compulsive Disorder
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Results confirmed that OCD is associated with polymorphisms of 5-HTTLPR, HTR2A, and, in males only, COMT.
|
26616111 |
2016 |
Obsessive-Compulsive Disorder
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
However, a significant difference was found between 5-HTT rs16965628 polymorphism and OCD (p=0.025, OR=3.43, 95% CI 1.41-10.35).
|
25751280 |
2015 |
Obsessive-Compulsive Disorder
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
A total of 1991 participants with OCD and their 5-HTTLPR allele status were examined.
|
25896187 |
2015 |
Obsessive-Compulsive Disorder
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
We conclude that the 5-HTTLPR is currently the single best supported risk variant for OCD, in regards of early-onset OCD, albeit of modest effect size and the possibility that the conferred risk might not be specific to OCD.
|
25093702 |
2014 |
Obsessive-Compulsive Disorder
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
In the main meta-analysis, OCD was associated with serotonin-related polymorphisms (5-HTTLPR and HTR2A) and, in males only, with polymorphisms involved in catecholamine modulation (COMT and MAOA).
|
22665263 |
2013 |
Obsessive-Compulsive Disorder
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Likewise, the higher expressing LAC haplotype (5-HTTLPR/rs25531/rs25532) was more frequent in TD probands than in controls (P = 0.024; OR, 1.33) and also in the TD alone group versus the TD plus OCD group (P = 0.0013; OR, 2.14).
|
23630162 |
2013 |
Obsessive-Compulsive Disorder
|
0.600 |
PosttranslationalModification
|
disease |
BEFREE |
These results are discussed in terms of their implications for our understanding of the sex-specific role of the different sections of the SLC6A4 gene in OCD.
|
22727904 |
2012 |
Obsessive-Compulsive Disorder
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Similarly, three individuals (two with OCD/OCPD) carried the rare I425V SLC6A4 variant, but none of them passed it on to their six OCD-affected offspring, suggesting that it is unlikely to be solely responsible for the 'OCD plus syndrome', as reported by Ozaki et al.
|
19806148 |
2011 |
Obsessive-Compulsive Disorder
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
The stronger effects of 5-HTT polymorphism on brain morphology in OCD than those in controls were determined in the both OFC and thalamus.
|
21441009 |
2011 |
Obsessive-Compulsive Disorder
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Our data show that genetic variation in the SLC6A4 gene regulatory region may not have a significant effect on OCD in the present population.
|
21245616 |
2010 |
Obsessive-Compulsive Disorder
|
0.600 |
GeneticVariation
|
disease |
LHGDN |
Within autism, rare hSERT coding variants associate with rigid-compulsive traits, suggesting both phenotypic overlap with OCD and a shared relationship with disrupted 5-HT signalling.
|
18957375 |
2009 |
Obsessive-Compulsive Disorder
|
0.600 |
Biomarker
|
disease |
BEFREE |
The human serotonin (5-hydroxytryptamine, 5-HT) transporter (hSERT, SLC6A4) figures prominently in the etiology and treatment of many prevalent neurobehavioral disorders including anxiety, alcoholism, depression, autism, and obsessive-compulsive disorder (OCD).
|
19179283 |
2009 |
Obsessive-Compulsive Disorder
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Within autism, rare hSERT coding variants associate with rigid-compulsive traits, suggesting both phenotypic overlap with OCD and a shared relationship with disrupted 5-HT signalling.
|
18957375 |
2009 |
Obsessive-Compulsive Disorder
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
The promoter region of the serotonin transporter gene (SLC6A4) shows a 22-bp tandem repeat polymorphism, indicated as polymorphism C, that has been associated to depression, obsessive-compulsive disorder, memory impairment, and anxiety.
|
18490109 |
2008 |
Obsessive-Compulsive Disorder
|
0.600 |
Biomarker
|
disease |
BEFREE |
Further meta-analyses based on individual patient data would be helpful in determining whether age of OCD onset, gender and the presence of comorbid illness (e.g., tics) moderates the relationship between 5-HTTLPR and OCD.
|
18186076 |
2008 |
Obsessive-Compulsive Disorder
|
0.600 |
GeneticVariation
|
disease |
LHGDN |
In a sample of Caucasian OCD patients, we explored the link between decision-making and the 5-HTTLPR.
|
18603313 |
2008 |
Obsessive-Compulsive Disorder
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Haplotype-based testing of rs25532 and all other known non-coding functional SLC6A4 variants revealed a highly significant omnibus association with OCD in a large case-control sample.
|
18055562 |
2008 |
Obsessive-Compulsive Disorder
|
0.600 |
Biomarker
|
disease |
CTD_human |
SERT Ileu425Val in autism, Asperger syndrome and obsessive-compulsive disorder.
|
18197083 |
2008 |