SLC6A4, solute carrier family 6 member 4, 6532

N. diseases: 440; N. variants: 28
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0041696
Disease: Unipolar Depression
Unipolar Depression
0.600 GeneticVariation disease BEFREE 5-HTTLPR and <i>MTHFR 677C</i>>T polymorphisms and response to yoga-based lifestyle intervention in major depressive disorder: A randomized active-controlled trial. 30581206 2020
CUI: C0041696
Disease: Unipolar Depression
Unipolar Depression
0.600 GeneticVariation disease BEFREE Rare variants in SLC6A4 cause susceptibility to major depressive disorder with suicidal ideation in Han Chinese adolescents and young adults. 31629822 2020
CUI: C0041696
Disease: Unipolar Depression
Unipolar Depression
0.600 GeneticVariation disease BEFREE We investigated whether single nucleotide polymorphisms (SNPs) associated with neuroplasticity and activity of monoamine neurotransmitters, such as the brain-derived neurotrophic factor (BDNF, rs6265), the serotonin transporter (SLC6A4, rs25531), the tryptophan hydroxylase 1 (TPH1, rs1800532), the 5-hydroxytryptamine receptor 2A (HTR2A, rs6311, rs6313, rs7997012), and the catechol-O-methyltransferase (COMT, rs4680) genes, are associated with efficacy of transcranial direct current stimulation (tDCS) in major depression. 31721892 2019
CUI: C0041696
Disease: Unipolar Depression
Unipolar Depression
0.600 GeneticVariation disease BEFREE Epigenetic variation at the SLC6A4 gene promoter in mother-child pairs with major depressive disorder. 30447571 2019
CUI: C0041696
Disease: Unipolar Depression
Unipolar Depression
0.600 GeneticVariation disease BEFREE Association between 5-HTTLPR polymorphism, suicide attempt and comorbidity in Mexican adolescents with major depressive disorder. 30724325 2019
CUI: C0041696
Disease: Unipolar Depression
Unipolar Depression
0.600 AlteredExpression disease BEFREE Improvement in depressive symptoms (HDRS score declined) and increasing in 5-HTT mRNA level were found with longer duration of antidepressant treatment in patients with major depression. 29957477 2018
CUI: C0041696
Disease: Unipolar Depression
Unipolar Depression
0.600 GeneticVariation disease BEFREE The effects of 5-HTTLPR and BDNF Val66Met polymorphisms on neurostructural changes in major depressive disorder. 29414128 2018
CUI: C0041696
Disease: Unipolar Depression
Unipolar Depression
0.600 GeneticVariation disease BEFREE The 5-HTTLPR and BDNF polymorphisms moderate the association between uncinate fasciculus connectivity and antidepressants treatment response in major depression. 27277475 2017
CUI: C0041696
Disease: Unipolar Depression
Unipolar Depression
0.600 GeneticVariation disease BEFREE Voxel-based morphometric brain comparison between healthy subjects and major depressive disorder patients in Japanese with the s/s genotype of 5-HTTLPR. 28638109 2017
CUI: C0041696
Disease: Unipolar Depression
Unipolar Depression
0.600 GeneticVariation disease BEFREE The current study is a preliminary investigation of the association of polymorphisms of the serotonin transporter (SLC6A4), dopamine transporter (DAT1), dopamine receptor D4 (DRD4), and catechol-O-methyl transferase (COMT) genes with theory of mind decoding in a sample of adults with major depression. 26974654 2016
CUI: C0041696
Disease: Unipolar Depression
Unipolar Depression
0.600 GeneticVariation disease BEFREE Effects of polymorphisms of serotonin transporter promoter (5-HTTLPR) and brain derived neurotrophic factor gene (G196A rs6265) on the risk of major depressive disorder in the Chinese Han population. 27212180 2016
CUI: C0041696
Disease: Unipolar Depression
Unipolar Depression
0.600 GeneticVariation disease BEFREE In medication-free patients with current major depressive disorder (MDD; N=21), we determined 5-HTTLPR genotype, employed functional magnetic resonance imaging (fMRI) to examine amygdala responses to negative emotional stimuli, and used positron emission tomography with [(11)C]DASB to examine 5-HTT binding. 26561939 2016
CUI: C0041696
Disease: Unipolar Depression
Unipolar Depression
0.600 GeneticVariation disease BEFREE Amygdala responses to quetiapine XR and citalopram treatment in major depression: the role of 5-HTTLPR-S/Lg polymorphisms. 26879101 2016
CUI: C0041696
Disease: Unipolar Depression
Unipolar Depression
0.600 GeneticVariation disease BEFREE Carrying a genetic variant in the serotonin transporter gene (5HTT) may increase the risk of major depressive disorder and alcohol dependence. 26979101 2016
CUI: C0041696
Disease: Unipolar Depression
Unipolar Depression
0.600 GeneticVariation disease BEFREE We conducted an 8-week, open-label, prospective pilot study in 35 patients with major depressive disorder to assess the effects of genetic variations in SLC6A2 and SLC6A4 on both efficacy and side effect profile of desvenlafaxine. 27023264 2016
CUI: C0041696
Disease: Unipolar Depression
Unipolar Depression
0.600 GeneticVariation disease BEFREE Our study included 2679 participants.Those with both the 5-HTTLPR s allele and the BDNF Met allele showed the highest risk of MD if they had previously experienced emotional (z = 2.08, p = 0.037), sexual (z = 2.19, p = 0.029) or any kind of childhood abuse (z = 2.37, p = 0.018). 25510949 2015
CUI: C0041696
Disease: Unipolar Depression
Unipolar Depression
0.600 Biomarker disease PSYGENET Serotonin transporter (5-HTTLPR) and norepinephrine transporter (NET) gene polymorphisms: susceptibility and treatment response of electroconvulsive therapy in treatment resistant depression. 25650523 2015
CUI: C0041696
Disease: Unipolar Depression
Unipolar Depression
0.600 Biomarker disease PSYGENET Our study included 2679 participants.Those with both the 5-HTTLPR s allele and the BDNF Met allele showed the highest risk of MD if they had previously experienced emotional (z = 2.08, p = 0.037), sexual (z = 2.19, p = 0.029) or any kind of childhood abuse (z = 2.37, p = 0.018). 25510949 2015
CUI: C0041696
Disease: Unipolar Depression
Unipolar Depression
0.600 GeneticVariation disease BEFREE Association of serotonin transporter (SLC6A4) and receptor (5HTR1A, 5HTR2A) polymorphisms with response to treatment with escitalopram in patients with major depressive disorder: A preliminary study. 26261165 2015
CUI: C0041696
Disease: Unipolar Depression
Unipolar Depression
0.600 Biomarker disease BEFREE Results show that 5-HTTLPR is strongly associated with the major depressive disorder in postpartum women. 24882202 2014
CUI: C0041696
Disease: Unipolar Depression
Unipolar Depression
0.600 GeneticVariation disease BEFREE Interaction of 5-HTT and HTR1A gene polymorphisms in treatment responses to mirtazapine in patients with major depressive disorder. 24911443 2014
CUI: C0041696
Disease: Unipolar Depression
Unipolar Depression
0.600 Biomarker disease PSYGENET Serotonin transporter gene hypomethylation predicts impaired antidepressant treatment response. 24679990 2014
CUI: C0041696
Disease: Unipolar Depression
Unipolar Depression
0.600 Biomarker disease PSYGENET Epigenetic and epistatic interactions between serotonin transporter and brain-derived neurotrophic factor genetic polymorphism: insights in depression. 24972302 2014
CUI: C0041696
Disease: Unipolar Depression
Unipolar Depression
0.600 PosttranslationalModification disease BEFREE The potential of SLC6A4 gene methylation analysis for the diagnosis and treatment of major depression. 24657235 2014
CUI: C0041696
Disease: Unipolar Depression
Unipolar Depression
0.600 GeneticVariation disease BEFREE The influence of 5-HTTLPR genotype on the association between the plasma concentration and therapeutic effect of paroxetine in patients with major depressive disorder. 24858363 2014