SLC6A4, solute carrier family 6 member 4, 6532

N. diseases: 440; N. variants: 28
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0525045
Disease: Mood Disorders
Mood Disorders
0.600 GeneticVariation group BEFREE The serotonin transporter (5-HTTLPR) and brain-derived neurotrophic factor (BDNF) gene polymorphisms have been associated with risk for affective disorders and functional variability of the amygdala. 30711709 2019
CUI: C0525045
Disease: Mood Disorders
Mood Disorders
0.600 Biomarker group BEFREE Human norepinephrine and serotonin transporters (hNET and hSERT) are closely related monoamine transporters (MATs) that regulate neurotransmitter signaling in neurons and are primary targets for a wide range of therapeutic drugs used in the treatment of mood disorders. 30457616 2018
CUI: C0525045
Disease: Mood Disorders
Mood Disorders
0.600 GeneticVariation group BEFREE Environmental vulnerability factors such as adverse childhood experiences in interaction with genetic risk variants, e.g., the serotonin transporter gene linked polymorphic region (5-HTTLPR), are assumed to play a role in the development of anxiety and affective disorders. 27145764 2016
CUI: C0525045
Disease: Mood Disorders
Mood Disorders
0.600 GeneticVariation group BEFREE Further, 2 genetic polymorphisms: the 5-HTTLPR and the brain-derived neurotrophic factor (BDNF) Val66Met polymorphisms were not directly associated with familial risk for affective disorder and did not predict illness onset. 27697135 2016
CUI: C0525045
Disease: Mood Disorders
Mood Disorders
0.600 GeneticVariation group BEFREE These findings provide novel evidence for both independent and interactive effects of 5-HTTLPR genotype and neuroticism on amygdala communication, which may mediate effects on risk for mood and affective disorders. 26245837 2016
CUI: C0525045
Disease: Mood Disorders
Mood Disorders
0.600 Biomarker group BEFREE 5-HTTLPR modulation of affective disorders varied by gender. 26519640 2016
CUI: C0525045
Disease: Mood Disorders
Mood Disorders
0.600 Biomarker group BEFREE Considering the allele-specific sensitivity of SLC6A4 methylation to SLEs, this study may help clarify the role of SLC6A4 in the development of affective disorders. 25849128 2015
CUI: C0525045
Disease: Mood Disorders
Mood Disorders
0.600 GeneticVariation group BEFREE The role of 5-HTTLPR and 5-HT2C Cys23Ser polymorphisms in the psychopathology of mood disorders and suicide behavior is controversial. 25596490 2015
CUI: C0525045
Disease: Mood Disorders
Mood Disorders
0.600 Biomarker group PSYGENET The role of 5-HTTLPR and 5-HT2C Cys23Ser polymorphisms in the psychopathology of mood disorders and suicide behavior is controversial. 25596490 2015
CUI: C0525045
Disease: Mood Disorders
Mood Disorders
0.600 GeneticVariation group BEFREE A functional polymorphism (5-HTTLPR) within the serotonin transporter gene (SERT) has been associated with personality dimensions such as neuroticism, with emotional reactivity to negative events, and with an increased risk of affective disorders. 25711941 2015
CUI: C0525045
Disease: Mood Disorders
Mood Disorders
0.600 GeneticVariation group BEFREE Gene variants of the 5-HT transporter, such as STin2 VNTR (a variable number of tandem repeats in the functional serotonin transporter intron 2) may be associated with mood disorders and TUD. 25451436 2015
CUI: C0525045
Disease: Mood Disorders
Mood Disorders
0.600 Biomarker group PSYGENET Analysis did not show any statistically significant differences in the mean levels of anxiety, and mood disorders in women in relation to genotypes of the 5-HTTLPR (SLC6A4) polymorphism and the 30-bp VNTR polymorphism in the MAO A promoter region. 25547397 2014
CUI: C0525045
Disease: Mood Disorders
Mood Disorders
0.600 GeneticVariation group BEFREE Although the serotonin transporter length polymorphic region (5-HTTLPR) polymorphism is an extensively-investigated genetic marker of anxiety related personality traits (neuroticism and harm avoidance) and affective disorders, effect sizes in meta-analyses are small, if present at all, and all available primary studies to date lack mandatory statistical power. 24438559 2014
CUI: C0525045
Disease: Mood Disorders
Mood Disorders
0.600 GeneticVariation group BEFREE Analysis did not show any statistically significant differences in the mean levels of anxiety, and mood disorders in women in relation to genotypes of the 5-HTTLPR (SLC6A4) polymorphism and the 30-bp VNTR polymorphism in the MAO A promoter region. 25547397 2014
CUI: C0525045
Disease: Mood Disorders
Mood Disorders
0.600 GeneticVariation group BEFREE The alleged association between the serotonin-transporter-linked polymorphic region (5-HTTLPR) and amygdala activation forms a cornerstone of the common view that carrying the short allele of this polymorphism is a potential risk factor for affective disorders. 25253281 2014
CUI: C0525045
Disease: Mood Disorders
Mood Disorders
0.600 Biomarker group PSYGENET Serotonin transporter gene methylation is associated with hippocampal gray matter volume. 24862560 2014
CUI: C0525045
Disease: Mood Disorders
Mood Disorders
0.600 Biomarker group PSYGENET Epigenetic and epistatic interactions between serotonin transporter and brain-derived neurotrophic factor genetic polymorphism: insights in depression. 24972302 2014
CUI: C0525045
Disease: Mood Disorders
Mood Disorders
0.600 Biomarker group PSYGENET Although the serotonin transporter length polymorphic region (5-HTTLPR) polymorphism is an extensively-investigated genetic marker of anxiety related personality traits (neuroticism and harm avoidance) and affective disorders, effect sizes in meta-analyses are small, if present at all, and all available primary studies to date lack mandatory statistical power. 24438559 2014
CUI: C0525045
Disease: Mood Disorders
Mood Disorders
0.600 Biomarker group BEFREE At 6 months post-injury, subjects with a history of pre-morbid mood disorders and 5-HTTLPR L-homozygotes were at greater risk for PTD. 23672445 2013
CUI: C0525045
Disease: Mood Disorders
Mood Disorders
0.600 GeneticVariation group BEFREE A functional polymorphism within the serotonin transporter gene (5-HTTLPR) has been reported to modulate emotionality and risk for affective disorders. 22345383 2013
CUI: C0525045
Disease: Mood Disorders
Mood Disorders
0.600 Biomarker group BEFREE Serotonin transporter gene (SLC6A4) has been shown to play an important role in the pathophysiology of mood disorders including poststroke depression (PSD). 23702251 2013
CUI: C0525045
Disease: Mood Disorders
Mood Disorders
0.600 GeneticVariation group BEFREE The 5-HTTLPR polymorphism has been widely regarded as a potential genetic risk factor for affective disorders. 22488255 2013
CUI: C0525045
Disease: Mood Disorders
Mood Disorders
0.600 GeneticVariation group BEFREE It is not known how 5-HTTLPR genotype x childhood adversity (CA) interactions that are associated with an increased risk for affective disorders in population studies operate at the neural systems level. 23034517 2012
CUI: C0525045
Disease: Mood Disorders
Mood Disorders
0.600 Biomarker group BEFREE The serotonin transporter (5HTT) plays an important role in the pathophysiology of mood disorders and may also be involved in suicidal behaviour since 5HTT binding is decreased in the brain of suicide completers. 21290142 2011
CUI: C0525045
Disease: Mood Disorders
Mood Disorders
0.600 AlteredExpression group BEFREE SLC6A4 expression was significantly increased in placentas from women with untreated mood disorders and from women treated with SSRIs, compared to controls. 21547899 2011