Major Depressive Disorder
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
The aim of this study was to examine the impact of common and rare variants of SLC6A4 on the risk of Han Chinese adolescents and young adults suffering MDD with SI.
|
31629822 |
2020 |
Major Depressive Disorder
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
5-HTTLPR variant of the serotonin transporter gene (SLC6A4) and <i>MTHFR 677C</i>>T polymorphisms have been linked to the pathogenesis of MDD, and antidepressant treatment response.
|
30581206 |
2020 |
Major Depressive Disorder
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Several promising genes, such as the COMT (catechol-O-methyltransferase) gene, the serotonin transporter gene (SLC6A4), and neuropeptide Y (NPY) suggest gene × environment interaction between genetic variants, childhood adversity, and the occurrence of PTSD and MDD, indicating an impact of these genes on resilience.
|
31583809 |
2020 |
Major Depressive Disorder
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Association between serotonin 2A receptor (HTR2A), serotonin transporter (SLC6A4) and brain-derived neurotrophic factor (BDNF) gene polymorphisms and citalopram/sertraline induced sexual dysfunction in MDD patients.
|
31792367 |
2019 |
Major Depressive Disorder
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Epigenetic patterns such as hypermethylation of the serotonin transporter gene (SLC6A4) have been associated with various mental disorders including MDD, but, to date, no association with PD has been reported.
|
31353282 |
2019 |
Major Depressive Disorder
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
We investigated whether single nucleotide polymorphisms (SNPs) associated with neuroplasticity and activity of monoamine neurotransmitters, such as the brain-derived neurotrophic factor (BDNF, rs6265), the serotonin transporter (SLC6A4, rs25531), the tryptophan hydroxylase 1 (TPH1, rs1800532), the 5-hydroxytryptamine receptor 2A (HTR2A, rs6311, rs6313, rs7997012), and the catechol-O-methyltransferase (COMT, rs4680) genes, are associated with efficacy of transcranial direct current stimulation (tDCS) in major depression.
|
31721892 |
2019 |
Major Depressive Disorder
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Association between 5-HTTLPR polymorphism, suicide attempt and comorbidity in Mexican adolescents with major depressive disorder.
|
30724325 |
2019 |
Major Depressive Disorder
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
This study examines whether lifetime episodes of MDD are associated with specific alterations in grey-matter volume, and whether those alterations vary according to sex or serotonin transporter-linked promoter region (5-HTTLPR) genotype (LL, SL or SS).
|
30565905 |
2019 |
Major Depressive Disorder
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
A preliminary association study between serotonin transporter (5-HTTLPR), receptor polymorphisms (5-HTR1A, 5-HTR2A) and depression symptom-clusters in a north Indian population suffering from Major Depressive Disorder (MDD).
|
31228794 |
2019 |
Major Depressive Disorder
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Using positron emission tomography (PET) and [<sup>11</sup>C]DASB, we studied relationships between 5-HTT binding potential and plasma levels of PUFAs docosahexaenoic acid (DHA), eicosapentaenoic acid (EPA), and arachidonic acid (AA) in medication-free MDD patients (n = 21).
|
31319341 |
2019 |
Major Depressive Disorder
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Epigenetic variation at the SLC6A4 gene promoter in mother-child pairs with major depressive disorder.
|
30447571 |
2019 |
Major Depressive Disorder
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
We aimed to investigate the effects of genetic variants of the 5-HTTLPR and BDNF Val66Met polymorphisms and their interactions with MDD on cortical volume and white matter integrity.
|
29414128 |
2018 |
Major Depressive Disorder
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Improvement in depressive symptoms (HDRS score declined) and increasing in 5-HTT mRNA level were found with longer duration of antidepressant treatment in patients with major depression.
|
29957477 |
2018 |
Major Depressive Disorder
|
0.600 |
Biomarker
|
disease |
BEFREE |
Using PET imaging with a radiotracer specific for the serotonin transporter (5-HTT), <sup>11</sup>C-McN5652, we found that patients with MDD who did not achieve remission after 12 mo of naturalistic treatment had lower pretreatment midbrain and amygdala binding than healthy volunteers.
|
28935838 |
2018 |
Major Depressive Disorder
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
These findings suggest a role of SLC6A4 AluJb methylation in MDD, amygdala reactivity, and stress reaction, partly interwoven with 5-HTTLPR/rs25531 effects.
|
29114103 |
2018 |
Major Depressive Disorder
|
0.600 |
Biomarker
|
disease |
BEFREE |
Dual inhibition of serotonin and norepinephrine transporters (hSERT and hNET) gives greatly improved efficacy and tolerability for treating major depressive disorder (MDD) compared with selective reuptake inhibitors.
|
29300091 |
2018 |
Major Depressive Disorder
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Total hippocampal volumes did not significantly vary in MDD participants or controls carrying either the BDNF Val66Met 'Met' (386 participants with MDD and 376 controls) or the 5-HTTLPR short 'S' (310 participants with MDD and 230 controls) risk alleles compared to non-carriers.
|
29778546 |
2018 |
Major Depressive Disorder
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
A suggested intermediate phenotype of MDD is emotion recognition: The 5-HTTLPR polymorphism of SLC6A4 as well as other serotonergic genes have been associated with amygdala and prefrontal function during emotion recognition.
|
29358097 |
2018 |
Major Depressive Disorder
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
This study examines whether lifetime episodes of MDD are associated with specific alterations in grey-matter volume, and whether those alterations vary according to sex or serotonin transporter-linked promoter region (5-HTTLPR) genotype (LL, SL or SS).
|
30226714 |
2018 |
Major Depressive Disorder
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
The 5-HTTLPR and BDNF polymorphisms moderate the association between uncinate fasciculus connectivity and antidepressants treatment response in major depression.
|
27277475 |
2017 |
Major Depressive Disorder
|
0.600 |
Biomarker
|
disease |
BEFREE |
Three candidate genes (HOMER1, SLC6A4 and TEF) were chosen for resequencing analysis and association studies as they were reported to be involved in the etiology of MDD and SA.
|
27964944 |
2017 |
Major Depressive Disorder
|
0.600 |
Biomarker
|
disease |
BEFREE |
The prevalence of short allele (s) homozygocity in the length polymorphism of the promoter region of the serotonin transporter gene (5-HTTLPR) was significantly higher in MDD patients relative to those with normal BR echogenicity.
|
27888722 |
2017 |
Major Depressive Disorder
|
0.600 |
PosttranslationalModification
|
disease |
BEFREE |
Therefore, 5-HTT methylation might be closely related with MDD in Chinese Han population because of the correlation with diurnal variation and weight.
|
27668354 |
2017 |
Major Depressive Disorder
|
0.600 |
Biomarker
|
disease |
BEFREE |
Positron emission tomography with [<sup>11</sup>C]-3-amino-4-(3-dimethylamino-methylphenylsulfanyl)-benzonitrile ([<sup>11</sup>C]DASB) and a metabolite-corrected arterial input function were used to estimate regional 5-HTT binding in 55 subjects with MDD and anxiety symptoms.
|
28811068 |
2017 |
Major Depressive Disorder
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Voxel-based morphometric brain comparison between healthy subjects and major depressive disorder patients in Japanese with the s/s genotype of 5-HTTLPR.
|
28638109 |
2017 |