Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder
0.600 GeneticVariation disease BEFREE The aim of this study was to examine the impact of common and rare variants of SLC6A4 on the risk of Han Chinese adolescents and young adults suffering MDD with SI. 31629822 2020
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder
0.600 GeneticVariation disease BEFREE 5-HTTLPR variant of the serotonin transporter gene (SLC6A4) and <i>MTHFR 677C</i>>T polymorphisms have been linked to the pathogenesis of MDD, and antidepressant treatment response. 30581206 2020
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder
0.600 GeneticVariation disease BEFREE Several promising genes, such as the COMT (catechol-O-methyltransferase) gene, the serotonin transporter gene (SLC6A4), and neuropeptide Y (NPY) suggest gene × environment interaction between genetic variants, childhood adversity, and the occurrence of PTSD and MDD, indicating an impact of these genes on resilience. 31583809 2020
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder
0.600 GeneticVariation disease BEFREE Association between serotonin 2A receptor (HTR2A), serotonin transporter (SLC6A4) and brain-derived neurotrophic factor (BDNF) gene polymorphisms and citalopram/sertraline induced sexual dysfunction in MDD patients. 31792367 2019
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder
0.600 GeneticVariation disease BEFREE Epigenetic patterns such as hypermethylation of the serotonin transporter gene (SLC6A4) have been associated with various mental disorders including MDD, but, to date, no association with PD has been reported. 31353282 2019
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder
0.600 GeneticVariation disease BEFREE We investigated whether single nucleotide polymorphisms (SNPs) associated with neuroplasticity and activity of monoamine neurotransmitters, such as the brain-derived neurotrophic factor (BDNF, rs6265), the serotonin transporter (SLC6A4, rs25531), the tryptophan hydroxylase 1 (TPH1, rs1800532), the 5-hydroxytryptamine receptor 2A (HTR2A, rs6311, rs6313, rs7997012), and the catechol-O-methyltransferase (COMT, rs4680) genes, are associated with efficacy of transcranial direct current stimulation (tDCS) in major depression. 31721892 2019
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder
0.600 GeneticVariation disease BEFREE Association between 5-HTTLPR polymorphism, suicide attempt and comorbidity in Mexican adolescents with major depressive disorder. 30724325 2019
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder
0.600 GeneticVariation disease BEFREE This study examines whether lifetime episodes of MDD are associated with specific alterations in grey-matter volume, and whether those alterations vary according to sex or serotonin transporter-linked promoter region (5-HTTLPR) genotype (LL, SL or SS). 30565905 2019
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder
0.600 GeneticVariation disease BEFREE A preliminary association study between serotonin transporter (5-HTTLPR), receptor polymorphisms (5-HTR1A, 5-HTR2A) and depression symptom-clusters in a north Indian population suffering from Major Depressive Disorder (MDD). 31228794 2019
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder
0.600 AlteredExpression disease BEFREE Using positron emission tomography (PET) and [<sup>11</sup>C]DASB, we studied relationships between 5-HTT binding potential and plasma levels of PUFAs docosahexaenoic acid (DHA), eicosapentaenoic acid (EPA), and arachidonic acid (AA) in medication-free MDD patients (n = 21). 31319341 2019
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder
0.600 GeneticVariation disease BEFREE Epigenetic variation at the SLC6A4 gene promoter in mother-child pairs with major depressive disorder. 30447571 2019
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder
0.600 GeneticVariation disease BEFREE We aimed to investigate the effects of genetic variants of the 5-HTTLPR and BDNF Val66Met polymorphisms and their interactions with MDD on cortical volume and white matter integrity. 29414128 2018
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder
0.600 AlteredExpression disease BEFREE Improvement in depressive symptoms (HDRS score declined) and increasing in 5-HTT mRNA level were found with longer duration of antidepressant treatment in patients with major depression. 29957477 2018
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder
0.600 Biomarker disease BEFREE Using PET imaging with a radiotracer specific for the serotonin transporter (5-HTT), <sup>11</sup>C-McN5652, we found that patients with MDD who did not achieve remission after 12 mo of naturalistic treatment had lower pretreatment midbrain and amygdala binding than healthy volunteers. 28935838 2018
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder
0.600 GeneticVariation disease BEFREE These findings suggest a role of SLC6A4 AluJb methylation in MDD, amygdala reactivity, and stress reaction, partly interwoven with 5-HTTLPR/rs25531 effects. 29114103 2018
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder
0.600 Biomarker disease BEFREE Dual inhibition of serotonin and norepinephrine transporters (hSERT and hNET) gives greatly improved efficacy and tolerability for treating major depressive disorder (MDD) compared with selective reuptake inhibitors. 29300091 2018
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder
0.600 GeneticVariation disease BEFREE Total hippocampal volumes did not significantly vary in MDD participants or controls carrying either the BDNF Val66Met 'Met' (386 participants with MDD and 376 controls) or the 5-HTTLPR short 'S' (310 participants with MDD and 230 controls) risk alleles compared to non-carriers. 29778546 2018
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder
0.600 GeneticVariation disease BEFREE A suggested intermediate phenotype of MDD is emotion recognition: The 5-HTTLPR polymorphism of SLC6A4 as well as other serotonergic genes have been associated with amygdala and prefrontal function during emotion recognition. 29358097 2018
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder
0.600 GeneticVariation disease BEFREE This study examines whether lifetime episodes of MDD are associated with specific alterations in grey-matter volume, and whether those alterations vary according to sex or serotonin transporter-linked promoter region (5-HTTLPR) genotype (LL, SL or SS). 30226714 2018
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder
0.600 GeneticVariation disease BEFREE The 5-HTTLPR and BDNF polymorphisms moderate the association between uncinate fasciculus connectivity and antidepressants treatment response in major depression. 27277475 2017
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder
0.600 Biomarker disease BEFREE Three candidate genes (HOMER1, SLC6A4 and TEF) were chosen for resequencing analysis and association studies as they were reported to be involved in the etiology of MDD and SA. 27964944 2017
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder
0.600 Biomarker disease BEFREE The prevalence of short allele (s) homozygocity in the length polymorphism of the promoter region of the serotonin transporter gene (5-HTTLPR) was significantly higher in MDD patients relative to those with normal BR echogenicity. 27888722 2017
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder
0.600 PosttranslationalModification disease BEFREE Therefore, 5-HTT methylation might be closely related with MDD in Chinese Han population because of the correlation with diurnal variation and weight. 27668354 2017
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder
0.600 Biomarker disease BEFREE Positron emission tomography with [<sup>11</sup>C]-3-amino-4-(3-dimethylamino-methylphenylsulfanyl)-benzonitrile ([<sup>11</sup>C]DASB) and a metabolite-corrected arterial input function were used to estimate regional 5-HTT binding in 55 subjects with MDD and anxiety symptoms. 28811068 2017
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder
0.600 GeneticVariation disease BEFREE Voxel-based morphometric brain comparison between healthy subjects and major depressive disorder patients in Japanese with the s/s genotype of 5-HTTLPR. 28638109 2017