|
Chronic Lymphocytic Leukemia
|
0.070 |
Biomarker
|
disease |
BEFREE |
We examined the chronic lymphocytic leukemia (CLL) cells of 2457 patients evaluated by the CLL Research Consortium (CRC) and found that 63 (2.6%) expressed immunoglobulin (Ig) encoded by the Ig heavy-chain-variable-region gene (IGHV), IGHV3-21.
|
18326815 |
2008 |
|
Chronic Lymphocytic Leukemia
|
0.070 |
GeneticVariation
|
disease |
BEFREE |
To address the proposition that familial B-cell chronic lymphocytic leukemia (CLL) may exhibit a more restricted phenotype than sporadic CLL with respect to immunoglobulin gene usage or ontogenic development, we compared immunoglobulin (Ig) heavy chain variable region (VH) gene usage and IgVH mutation status in 327 patients with CLL from 214 families with 724 patients with sporadic cases.
|
18424666 |
2008 |
|
Chronic Lymphocytic Leukemia
|
0.070 |
GeneticVariation
|
disease |
BEFREE |
The methods identified 144 genes that were differentially expressed between cases of CLL with unmutated compared with mutated Ig VH genes.
|
16049305 |
2005 |
|
Chronic Lymphocytic Leukemia
|
0.070 |
Biomarker
|
disease |
BEFREE |
We examined the immunoglobulin (Ig) heavy chain variable region genes (V(H) genes) used by leukemia cells of 1220 unrelated patients with chronic lymphocytic leukemia (CLL).
|
15217828 |
2004 |
|
Chronic Lymphocytic Leukemia
|
0.070 |
AlteredExpression
|
disease |
BEFREE |
In five of the six unmutated CLLs, the DLBL clones evolved from CLL tumorclones and the VH genes expressed by DLBLs were also unmutated.
|
14671632 |
2004 |
|
Chronic Lymphocytic Leukemia
|
0.070 |
AlteredExpression
|
disease |
BEFREE |
Prior studies revealed that the leukemic B cells of patients with chronic lymphocytic leukemia (CLL) express a restricted Ig heavy chain variable region gene (VH gene) repertoire.
|
8977195 |
1997 |
|
Chronic Lymphocytic Leukemia
|
0.070 |
AlteredExpression
|
disease |
BEFREE |
Thus, from our present observation of an albeit limited patient population, we have found an association between VH gene family use and CD5 antigen expression in chronic B-cell leukemias.
|
7513207 |
1994 |
|
Neoplasms
|
0.030 |
GeneticVariation
|
group |
BEFREE |
Although most of the VH genes expressed by DLC tumor cells contained mutations with respect to their germline counterparts, almost all of these mutations occurred before the clonal expansion of the tumor.
|
7579401 |
1995 |
|
Neoplasms
|
0.030 |
AlteredExpression
|
group |
BEFREE |
The immunoglobulin (Ig) heavy chain variable region (VH) gene sequence expressed by the malignant clone in MM can be used as a tumor specific marker.
|
7475288 |
1995 |
|
Neoplasms
|
0.030 |
AlteredExpression
|
group |
BEFREE |
Differential usage of an Ig heavy chain variable region gene by human B-cell tumors.
|
8324224 |
1993 |
|
Mucosa-Associated Lymphoid Tissue Lymphoma
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
The observed patterns of V(H) usage and mutations suggested that specific antigens may play a pathologically relevant role in the genesis or progression of thymic MALT lymphoma.
|
16353132 |
2006 |
|
Familial primary gastric lymphoma
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
The observed patterns of V(H) usage and mutations suggested that specific antigens may play a pathologically relevant role in the genesis or progression of thymic MALT lymphoma.
|
16353132 |
2006 |
|
Diffuse Large B-Cell Lymphoma
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
In five of the six unmutated CLLs, the DLBL clones evolved from CLL tumorclones and the VH genes expressed by DLBLs were also unmutated.
|
14671632 |
2004 |
|
Multiple Myeloma
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
To characterize multiple myeloma (MM) from the viewpoint of the immunoglobulin (Ig) gene structure, we compared the transcripts of the Ig heavy chain variable region from 23 MM samples with 221 clones of the gamma, alpha and mu chain transcripts amplified by the reverse transcriptase-polymerase chain reaction (RT-PCR) from normal bone marrow (BM) cells.
|
8892685 |
1996 |
|
Lymphoma, Follicular
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
Ig heavy chain variable region (VH) genes expressed by human diffuse large-cell lymphoma (DLC) and follicular lymphoma (FL) were identified and analyzed with respect to germline gene families.
|
7579401 |
1995 |
|
Multiple Myeloma
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
The immunoglobulin (Ig) heavy chain variable region (VH) gene sequence expressed by the malignant clone in MM can be used as a tumor specific marker.
|
7475288 |
1995 |
|
Diffuse Large B-Cell Lymphoma
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
Although most of the VH genes expressed by DLC tumor cells contained mutations with respect to their germline counterparts, almost all of these mutations occurred before the clonal expansion of the tumor.
|
7579401 |
1995 |
|
Mucosa-Associated Lymphoid Tissue Lymphoma
|
0.020 |
Biomarker
|
disease |
BEFREE |
Based on the CDR3 sequence amplified from each MALT lymphoma, individual tumor-specific primers were synthesized and used directly in the polymerase chain reaction (PCR) to analyze the sequences of their Ig heavy-chain variable region.
|
7579460 |
1995 |
|
Familial primary gastric lymphoma
|
0.020 |
Biomarker
|
disease |
BEFREE |
Based on the CDR3 sequence amplified from each MALT lymphoma, individual tumor-specific primers were synthesized and used directly in the polymerase chain reaction (PCR) to analyze the sequences of their Ig heavy-chain variable region.
|
7579460 |
1995 |
|
Lymphoma, Follicular
|
0.020 |
Biomarker
|
disease |
BEFREE |
The frequency of VH family use in FL was found to be similar to that reported for normal peripheral blood lymphocytes and is therefore also roughly proportional to VH family size.
|
1909196 |
1991 |
|
B-CELL MALIGNANCY, LOW-GRADE
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
To address the proposition that familial B-cell chronic lymphocytic leukemia (CLL) may exhibit a more restricted phenotype than sporadic CLL with respect to immunoglobulin gene usage or ontogenic development, we compared immunoglobulin (Ig) heavy chain variable region (VH) gene usage and IgVH mutation status in 327 patients with CLL from 214 families with 724 patients with sporadic cases.
|
18424666 |
2008 |
|
Richter's syndrome
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
To reveal whether Richter's syndrome occurs in CLLs with mutated or unmutated VH genes, we have performed mutational analysis on serial specimens from eight patients.
|
14671632 |
2004 |
|
Adult Diffuse Large B-Cell Lymphoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
In five of the six unmutated CLLs, the DLBL clones evolved from CLL tumorclones and the VH genes expressed by DLBLs were also unmutated.
|
14671632 |
2004 |
|
Glioblastoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
In addition, human glioblastoma cells stably overexpressing a fusion protein between SLC7A4 and the enhanced green fluorescent protein (EGFP) did not exhibit an increased transport activity for l-arginine.
|
12049641 |
2002 |
|
Teratocarcinoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
The expression of SLC7A4 can be induced in NT2 teratocarcinoma cells by treatment with retinoic acid.
|
12049641 |
2002 |