SLC11A1, solute carrier family 11 member 1, 6556

N. diseases: 141; N. variants: 14
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0010346
Disease: Crohn Disease
Crohn Disease
0.400 Biomarker disease BEFREE Among them, the Solute Carrier family 11 member A1 (SLC11A1) has been implicated with susceptibility to infection by Mycobacterium avium subspecies paratuberculosis (MAP), potentially causing Crohn's disease in humans and paratuberculosis (PTB) in ruminants. 30543052 2019
CUI: C0010346
Disease: Crohn Disease
Crohn Disease
0.400 GeneticVariation disease BEFREE No significant association between allele 2 frequency of NRAMP1 and susceptibility to UC/CD was detected in overall population (all p > 0.05). 27019053 2016
CUI: C0010346
Disease: Crohn Disease
Crohn Disease
0.400 Biomarker disease BEFREE Although SLC11A1 was not associated with IBD, association with MAP suggests that SLC11A1 is important in determining susceptibility to bacteria implicated in the etiology of CD. 21128323 2010
CUI: C0010346
Disease: Crohn Disease
Crohn Disease
0.400 GeneticVariation disease BEFREE For SLC11A1, alleles 1 and 2 were significant (P < 0.05) for UC, but only allele 3 was significant (P < 0.05) for CD. 18340647 2008
CUI: C0010346
Disease: Crohn Disease
Crohn Disease
0.400 GeneticVariation disease BEFREE Three NRAMP1 polymorphisms [5'(GT)n, D543N, and INT4G/C] were significantly associated with CD. 18454481 2008
CUI: C0010346
Disease: Crohn Disease
Crohn Disease
0.400 GeneticVariation disease LHGDN Three NRAMP1 polymorphisms [5'(GT)n, D543N, and INT4G/C] were significantly associated with CD. 18454481 2008
CUI: C0010346
Disease: Crohn Disease
Crohn Disease
0.400 GeneticVariation disease BEFREE The aim of this study was to check for a possible association between SLC11A1 promoter alleles and CD in Ashkenazi Jewish patients. 17385031 2007
CUI: C0010346
Disease: Crohn Disease
Crohn Disease
0.400 GeneticVariation disease LHGDN While CD was strongly associated with both NRAMP1 and MAP, NRAMP1 polymorphisms and MAP themselves were not correlated. 17131479 2006
CUI: C0010346
Disease: Crohn Disease
Crohn Disease
0.400 Biomarker disease CTD_human The -237C-->T promoter polymorphism of the SLC11A1 gene is associated with a protective effect in relation to inflammatory bowel disease in the South African population. 16059695 2006
CUI: C0010346
Disease: Crohn Disease
Crohn Disease
0.400 GeneticVariation disease BEFREE While CD was strongly associated with both NRAMP1 and MAP, NRAMP1 polymorphisms and MAP themselves were not correlated. 17131479 2006
CUI: C0010346
Disease: Crohn Disease
Crohn Disease
0.400 GeneticVariation disease BEFREE This study did not provide compelling evidence for SLC11A1 disease association; most significantly, there was no apparent evidence of SLC11A1 promoter allele association in the studied Crohn's disease population. 15757519 2005
CUI: C0010346
Disease: Crohn Disease
Crohn Disease
0.400 Biomarker disease BEFREE SLC11A1 regulates macrophage functions that are of potential importance in the induction and/or maintenance of autoimmune diseases such as rheumatoid arthritis, type I diabetes and Crohn's disease. 15584484 2004
CUI: C0010346
Disease: Crohn Disease
Crohn Disease
0.400 GeneticVariation disease BEFREE We studied markers in the genes for NRAMP1 and two mutations in the interferon-gamma receptor in relation to inflammatory bowel disease (IBD) in the following groups: 270 healthy individuals, 74 patients with Crohn's disease, 72 patients with ulcerative colitis, and 40 patients with primary sclerosing cholangitis. 10207725 1999
CUI: C0010346
Disease: Crohn Disease
Crohn Disease
0.400 GeneticVariation disease BEFREE This study is the first to report an association between the NRAMP gene and Crohn's disease. 9288120 1997