SLC11A1, solute carrier family 11 member 1, 6556

N. diseases: 141; N. variants: 14
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0041296
Disease: Tuberculosis
Tuberculosis
0.600 GeneticVariation disease BEFREE We made a minireview on the association of many candidate genes with TB based on recent research studies systematically, such as the human leukocyte antigen (HLA) gene, the solute carrier family 11 member 1 (SLC11A1) gene system, the vitamin D receptor (VDR) gene, the mannan-binding lectin (MBL) gene, the nitric oxide synthase 2A (NOS2A) gene, the speckled 110 (SP110) gene, and the P2X7 receptor (P2X7) gene. 31485302 2019
CUI: C0041296
Disease: Tuberculosis
Tuberculosis
0.600 Biomarker disease BEFREE The SLC11A1 gene has been reported to play a role in neutrophil function and is associated with susceptibility to infectious and inflammatory diseases such as tuberculosis or rheumatoid arthritis. 31230160 2019
CUI: C0041296
Disease: Tuberculosis
Tuberculosis
0.600 Biomarker disease BEFREE Studies have reported genetic markers to predict TB development in human leukocyte antigen (HLA) and non-HLA genes like killer immunoglobulin-like receptor (KIR), toll-like receptors (TLRs), cytokine/chemokines and their receptors, vitamin D receptor (VDR) and SLC11A1 etc. 30167433 2018
CUI: C0041296
Disease: Tuberculosis
Tuberculosis
0.600 GeneticVariation disease BEFREE 3'UTR-NRAMP1 gene and VDR-Taq1 gene Polymorphisms are statistically associated with the susceptibility of TB in Andhra Pradesh Population in India. 28583097 2017
CUI: C0041296
Disease: Tuberculosis
Tuberculosis
0.600 GeneticVariation disease BEFREE Two genotypes of SLC11A1-SNP3 were susceptible to TB, whereas one genotype of SLC11A1-SNP1 and two genotypes of SLC11A1-SNP5 were resistant. 28237028 2017
CUI: C0041296
Disease: Tuberculosis
Tuberculosis
0.600 GeneticVariation disease BEFREE Among the subjects, D543N NRAMP1 polymorphism, history of contact with TB patients, and not having a clear BCG scar on the upper arm tended to be significantly association with active TB. 25596570 2015
CUI: C0041296
Disease: Tuberculosis
Tuberculosis
0.600 GeneticVariation disease BEFREE The (GT)n promoter alleles 2 and 3 (rs534448891), which alter SLC11A1 expression, were significantly associated with tuberculosis (OR=1.47 (1.30-1.66), OR=0.76 (0.65-0.89), respectively) and infectious disease (OR=1.25 (1.10-1.42), OR=0.83 (0.74-0.93), respectively). 25856512 2015
CUI: C0041296
Disease: Tuberculosis
Tuberculosis
0.600 Biomarker disease BEFREE Many genes involved in tuberculosis susceptibility (e.g., NRAMP1 (SLC11A1), IFNG, NOS2A, VDR, ISG15, TACO, TLR1, TLR, IL18R1, chemokines, PADI, DUSP14, MBL, and MASP-2) have been subjected to epigenetic modification. 26559095 2015
CUI: C0041296
Disease: Tuberculosis
Tuberculosis
0.600 GeneticVariation disease BEFREE An association study of NRAMP1, VDR, MBL and their interaction with the susceptibility to tuberculosis in a Chinese population. 26261060 2015
CUI: C0041296
Disease: Tuberculosis
Tuberculosis
0.600 GeneticVariation disease BEFREE This study confirms the previously described association of the NRAMP1 3'UTR polymorphism with M. tuberculosis infection and disease progression. 26578819 2015
CUI: C0041296
Disease: Tuberculosis
Tuberculosis
0.600 Biomarker disease BEFREE Multiple host iron status biomarkers, Haptoglobin and solute carrier family 11, member 1 (SLC11A1) genotypes were modeled to characterize how indicators of host iron metabolism were associated with TB susceptibility. 23360117 2013
CUI: C0041296
Disease: Tuberculosis
Tuberculosis
0.600 GeneticVariation disease BEFREE Polymorphisms in the NRAMP1 gene, VDR gene, HLA-DRB1 gene, and HLA-DQB1 gene are statistically associated with susceptibility to TB in the Chinese Kazakh population. 24024195 2013
CUI: C0041296
Disease: Tuberculosis
Tuberculosis
0.600 GeneticVariation disease BEFREE Susceptibility to TB-IRD associated with carriage of TNFA-1031*T (rs1799964; P=0.05) and SLC11A1 D543N*G (rs17235409; P=0.04) in Cambodian patients and carriage of IL18-607*G (rs1946518; P=0.02) and VDR FokI (F/f)*T (rs10735810; P=0.05) in Indian patients. 23594560 2013
CUI: C0041296
Disease: Tuberculosis
Tuberculosis
0.600 GeneticVariation disease BEFREE In this study, we evaluated the association between NRAMP1 gene polymorphisms and the risk of the development of active TB in Tunisian populations. 22609013 2012
CUI: C0041296
Disease: Tuberculosis
Tuberculosis
0.600 GeneticVariation disease BEFREE This meta-analysis suggests that polymorphisms in the SLC11A1 gene contribute to TB (both PTB and EPTB), particularly in Asians. 22326178 2012
CUI: C0041296
Disease: Tuberculosis
Tuberculosis
0.600 Biomarker disease BEFREE The association between SLC11A1 polymorphisms and tuberculosis susceptibility observed in our analyses supports the hypothesis that NRAMP1 might play an important role in the host defense to the development of tuberculosis. 21283567 2011
CUI: C0041296
Disease: Tuberculosis
Tuberculosis
0.600 GeneticVariation disease BEFREE SLC11A1 and VDR gene variants and susceptibility to tuberculosis and disease progression in East India. 22008758 2011
CUI: C0041296
Disease: Tuberculosis
Tuberculosis
0.600 GeneticVariation disease BEFREE To test this, we determined the frequency of an allele (SLC11A1 1729 + 55del4) associated with natural resistance to intracellular pathogens such as tuberculosis and leprosy. 20840594 2011
CUI: C0041296
Disease: Tuberculosis
Tuberculosis
0.600 GeneticVariation disease BEFREE The natural resistance-associated macrophage protein 1 (NRAMP1) gene is associated with susceptibility to Mycobacterium tuberculosis in humans and to bacillus Calmette-Guérin (BCG) in mice. 21163569 2011
CUI: C0041296
Disease: Tuberculosis
Tuberculosis
0.600 GeneticVariation disease BEFREE Several important candidate genes like human leucocyte antigen/alleles and non-human leucocyte antigen genes, such as cytokines and their receptors, chemokines and their receptors, pattern recognition receptors (including toll-like receptors, mannose binding lectin and the dendritic cell-specific intercellular adhesion molecule-3 grabbing nonintegrin), solute carrier family 11A member 1 (formerly known as natural resistance-associated macrophage protein 1) and purinergic P2X7 receptor gene polymorphisms, have been associated with differential susceptibility to TB in various ethnic populations. 20199642 2010
CUI: C0041296
Disease: Tuberculosis
Tuberculosis
0.600 GeneticVariation disease BEFREE Similarly, no significant differences were observed between NRAMP1 polymorphisms and rheumatoid factor positivity and erosive disease in RA and localization of TB. 19055603 2009
CUI: C0041296
Disease: Tuberculosis
Tuberculosis
0.600 GeneticVariation disease BEFREE We examined the association between SLC11A1 polymorphisms and susceptibility to tuberculosis in Han Chinese children. 19193106 2009
CUI: C0041296
Disease: Tuberculosis
Tuberculosis
0.600 GeneticVariation disease BEFREE SLC11A1 polymorphism rs3731865 was associated with TB in African-Americans, consistent with previous findings in West Africans. 19723394 2009
CUI: C0041296
Disease: Tuberculosis
Tuberculosis
0.600 Biomarker disease BEFREE The natural resistance-associated macrophage protein (NRAMP1), Vitamin-D receptor (VDR) and Tumor necrosis factor (TNF-alpha) have been associated in susceptibility to tuberculosis, but the results have been inconsistent. 20231985 2009
CUI: C0041296
Disease: Tuberculosis
Tuberculosis
0.600 GeneticVariation disease BEFREE The M. tuberculosis Beijing genotype, which comprised 29.8% of all isolates, was strongly associated with 2 polymorphisms in SLC11A1: the D543N G allele (odds ratio [OR], 2.15; P=.005) and the 3' untranslated region (3'UTR) insertion/insertion genotype (OR, 2.5; P=.001). 19863441 2009