Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
ARID1A (AT-rich interactive domain-containing protein 1A), a subunit of SWI/SNF complexes, is considered as a tumor suppressor in many cancers.
|
28253716 |
2019 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
SWI/SNF component <i>ARID1A</i> restrains pancreatic neoplasia formation.
|
30315093 |
2019 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
This review addresses three main neoplastic categories that are associated with specific paraneoplastic phenomena: (1) neoplasms having in common the presence of diffuse mixed inflammatory infiltration (closely simulating an inflammatory pseudotumor) and frequently associated with constitutional symptoms; (2) neoplasms with undifferentiated, anaplastic or rhabdoid cell morphology (frequently SWI/SNF-deficient) associated with diverse paraneoplastic manifestations; and (3) paraneoplasia associated with neoplasms carrying specific gene fusions such as solitary fibrous tumor (STAT6-NAB2 gene fusions), infantile fibrosarcoma and congenital mesoblastic nephroma (ETV6-NTRK3 gene fusions), and angiomatoid fibrous histiocytoma (EWSR1-CREB1 & EWSR1-ATF1 fusions).
|
30819530 |
2019 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
The SWI/SNF-family chromatin remodeling protein ATRX is a tumor suppressor in sarcomas, gliomas and other malignancies.
|
30970016 |
2019 |
Neoplasms
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Together, these studies identify a genetic connection between mutations in the SWI/SNF chromatin-remodeling complex and the tumor suppressor gene <i>TP53</i> and provide preclinical evidence to support the targeting of MDM2 and MDM4 in this often-fatal pediatric cancer.
|
30755442 |
2019 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
BRM: the core ATPase subunit of SWI/SNF chromatin-remodelling complex-a tumour suppressor or tumour-promoting factor?
|
31722744 |
2019 |
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Thus, deregulation of SWI/SNF activity could provide a unifying pathogenic mechanism for the large group of tumors caused by FET fusion oncoproteins.
|
30962207 |
2019 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
ARID1A, a component of the SWI/SNF chromatin remodeling complex, is a tumor suppressor with a high frequency of inactivating mutations in many cancers.
|
30097580 |
2018 |
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Examples include the mutations in ARID1A with cancer-driving effects, associations of tumor SWI/SNF gene expression levels and patient survival times, and two BRM promoter region polymorphisms linked to risk or patient outcomes in multiple human cancers.
|
29482773 |
2018 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
SWI/SNF complexes are mutated in ~20% across human cancers and dependency of SWI/SNF-deficient tumors on EZH2 has been uncovered recently.
|
30138427 |
2018 |
Neoplasms
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Variable loss of SMARCB1, ARID1A, and SMARCC1 was observed in 1 of 31, 2 of 31, and 1 of 29 evaluable cases, respectively; 3 of these 4 SWI/SNF-deficient tumors had confirmed FH mutations.
|
29689242 |
2018 |
Neoplasms
|
0.100 |
GeneticVariation
|
group |
BEFREE |
These findings provide the mechanistic basis for further development of OXPHOS inhibitors as therapeutics against SWI/SNF mutant tumors.
|
29892061 |
2018 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
In addition, patients with SWI/SNF complex-inactivated tumors had a significantly worse disease-specific survival (P=0.02).
|
28863077 |
2018 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
This review summarizes the most important SWI/SNF-driven diseases with a main focus on neoplasms.
|
29397238 |
2018 |
Neoplasms
|
0.100 |
GeneticVariation
|
group |
BEFREE |
This review will focus on recent advances in the understanding of the molecular pathogenesis of a subset of tumors in which alterations in the polycomb family of chromatin modifying complexes, the SWI/SNF family of nucleosome remodelers, and histones play a central role in disease pathogenesis.
|
28885261 |
2017 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
In this article, we make use of a <i>Drosophila</i> genetic model for epithelial tumor formation to explore the tumor suppressive role of SWI/SNF complex proteins.
|
28754838 |
2017 |
Neoplasms
|
0.100 |
GeneticVariation
|
group |
BEFREE |
ARID1A, an SWI/SNF chromatin-remodeling gene, is commonly mutated in cancer and hypothesized to be tumor suppressive.
|
29136504 |
2017 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
The AT-rich interactive domain 1A (ARID1A) gene encodes a member of the switch/sucrose nonfermentable (SWI-SNF) chromatin remodeling complex, and is considered to work as a tumor suppressor in concert with p53.
|
26067140 |
2017 |
Neoplasms
|
0.100 |
GeneticVariation
|
group |
BEFREE |
PRC2-mediated repression of SMARCA2 predicts EZH2 inhibitor activity in SWI/SNF mutant tumors.
|
29087303 |
2017 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
There was a loss of the SWI/SNF complex in a subset of the tumors with a heterogeneous pattern of the papillary carcinoma and anaplastic carcinoma components: SMARCA4 in 4% and PBRM1 in 4%.
|
28731042 |
2017 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
The Snf5/SMARCB1/INI1 subunit of SWI/SNF is a tumor suppressor frequently lost in pediatric rhabdoid cancers.
|
28249160 |
2017 |
Neoplasms
|
0.100 |
GeneticVariation
|
group |
BEFREE |
<b>Introduction:</b> BRM, a key catalytic subunit of the SWI/SNF chromatin remodeling complex, is a putative tumor susceptibility gene that is silenced in 15% of non-small cell lung cancer (NSCLC).
|
27827316 |
2017 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
A growing number of studies suggest critical tumor suppressor roles of the SWI/SNF chromatin remodeling complex in a variety of human cancers.
|
28256572 |
2017 |
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Four studies in this issue report new mechanisms underlying the function of the chromatin remodeling SWI/SNF complex in controlling gene expression and suppressing tumor development, providing valuable insights into the treatment of cancers harboring mutations in genes encoding SWI/SNF complex subunits.
|
28138149 |
2017 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Taken together, our findings provide new mechanistic insights on genomic instability linked to helicase-like transcription factor deregulation, and strongly suggest a tumor suppressor function of the SWI/SNF protein in acute myeloid leukemia.
|
26802049 |
2016 |