SMS, spermine synthase, 6611

N. diseases: 263; N. variants: 9
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0700095
Disease: Central neuroblastoma
Central neuroblastoma
0.070 Biomarker disease BEFREE SMS localized together with MyoVa in cytoplasmic vesicles of breast cancer MCF-7 and neuroblastoma SH-SY5Y cell lines, known to produce exosomes. 30733278 2019
CUI: C0700095
Disease: Central neuroblastoma
Central neuroblastoma
0.070 Biomarker disease BEFREE Treating four established NB cells lines (SMS-KCNR, SH-SY5Y, BE(2)-C, CHLA-90) and two primary NB cell lines with Tolcapone for 48 h decreased cell viability in a dose-dependent manner, with IncuCyte imaging and Western blotting indicating that cell death was due to caspase-3-mediated apoptosis. 28429453 2017
CUI: C0700095
Disease: Central neuroblastoma
Central neuroblastoma
0.070 Biomarker disease BEFREE In SMS-KNCR neuroblastoma cells, 13-cis-RA upregulated expression of Bcl-2 and Bcl-xL RNA and protein, and this was associated with protection from etoposide-mediated apoptosis at the mitochondrial level. 21159604 2010
CUI: C0700095
Disease: Central neuroblastoma
Central neuroblastoma
0.070 Biomarker disease BEFREE In vitro studies with daunorubicin linked to the carrier peptide via an acid-labile hydrazone bond demonstrated comparable cytotoxicity to daunorubicin in various daunorubicin sensitive cell lines (neuroblastoma cell lines SK-N-MC and SMS-KAN; HEK 293 T cells). 14523941 2004
CUI: C0700095
Disease: Central neuroblastoma
Central neuroblastoma
0.070 Biomarker disease BEFREE p27Kip1: a key mediator of retinoic acid induced growth arrest in the SMS-KCNR human neuroblastoma cell line. 9681834 1998
CUI: C0700095
Disease: Central neuroblastoma
Central neuroblastoma
0.070 AlteredExpression disease BEFREE This gene is also expressed in the SMS-KAN neuroblastoma cell line. 9192834 1997
CUI: C0700095
Disease: Central neuroblastoma
Central neuroblastoma
0.070 Biomarker disease BEFREE Induction of neuronal differentiation in SMS-KCNR neuroblastoma cells using retinoic acid resulted in an increase in Hsp27. 8169976 1994