SNCA, synuclein alpha, 6622

N. diseases: 449; N. variants: 66
Disease: Alcohol Use Disorder ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0001956
Disease: Alcohol Use Disorder
Alcohol Use Disorder 		0.330 Biomarker disease BEFREE Since the comorbidity between AUD and anxiety is very high and because anxiety is an important factor in ethanol (EtOH) relapse, the aim of the present study was to investigate the role of α-synuclein in moderating EtOH intake, the anxiolytic effects of EtOH, and EtOH withdrawal-induced anxiety and convulsions in mice. 30120834 2018
CUI: C0001956
Disease: Alcohol Use Disorder
Alcohol Use Disorder 		0.330 Biomarker disease BEFREE Fifteen candidate gene studies showed hypermethylation of promoter regions of six genes (AVP, DNMT3B, HERP, HTR3A, OPRM1, and SNCA) or hypomethylation of the GDAP1 promoter region in AUD subjects. 27759945 2017
CUI: C0001956
Disease: Alcohol Use Disorder
Alcohol Use Disorder 		0.330 GeneticVariation disease BEFREE Other studies demonstrated that variability in the SNCA promoter is also associated with alcohol use disorders, but not consistently. 19196539 2009
CUI: C0001956
Disease: Alcohol Use Disorder
Alcohol Use Disorder 		0.330 Biomarker disease CTD_human Alpha synuclein protein levels are increased in serum from recently abstinent cocaine abusers. 18055133 2008