SOD2, superoxide dismutase 2, 6648

N. diseases: 668; N. variants: 32
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0018802
Disease: Congestive heart failure
Congestive heart failure
0.570 AlteredExpression disease BEFREE Our results provide evidence that defective SOD2 may lead to toxic increases in the levels of damaging oxygen radicals in the neonatal heart, which can result in rapidly developing heart failure and death. 31494578 2020
CUI: C0018802
Disease: Congestive heart failure
Congestive heart failure
0.570 AlteredExpression disease BEFREE Curcumin-treated HF mice displayed enhanced exercise performance compared with vehicle-treated HF mice; 2) both soleus (Sol) and extensor digitorum longus (EDL) muscles of HFrEF mice exhibited reduced force and rapid fatigue, which were ameliorated by curcumin; and 3) protein expression of Nrf2, hemeoxygenase-1, SOD2, myogenin, and MyoD were significantly lower, but total ubiquitinated proteins, MURF1, and atrogen-1 were higher in Sol and EDL of HFrEF compared with sham mice, whereas these alterations in Nrf2 signaling and antioxidant defenses in HFrEF were attenuated by curcumin, which had no effect on cardiac function per se in mice with severe HFrEF. 30462567 2019
CUI: C0018802
Disease: Congestive heart failure
Congestive heart failure
0.570 Biomarker disease BEFREE Publisher Correction: MicroRNAs regulating superoxide dismutase 2 are new circulating biomarkers of heart failure. 30498227 2018
CUI: C0018802
Disease: Congestive heart failure
Congestive heart failure
0.570 AlteredExpression disease BEFREE MID in HF was associated with preserved activity of respiratory chain enzymes but reduced activity of aconitase and citrate synthase (by -26% and -15%, P < 0.05) and reduced expression of catalase, glutathione peroxidase, and superoxide dismutase 2. 27647766 2017
CUI: C0018802
Disease: Congestive heart failure
Congestive heart failure
0.570 Biomarker disease BEFREE MicroRNAs regulating superoxide dismutase 2 are new circulating biomarkers of heart failure. 29116107 2017
CUI: C0018802
Disease: Congestive heart failure
Congestive heart failure
0.570 AlteredExpression disease BEFREE Eplerenone alone increased the production of NO, MnSOD and CuZnSOD activity, arginase I gene and protein expression, and mannose receptor gene and protein expression, but decreased mineralocorticoid activity only in “heart failure” macrophages. 24486397 2014
CUI: C0018802
Disease: Congestive heart failure
Congestive heart failure
0.570 AlteredExpression disease BEFREE Known epigenetic changes contributing to CVD include hypomethylation in proliferating vascular smooth muscle cells in atherosclerosis, changes in estrogen receptor-α (ER-α) and ER-β methylation in vascular disease, decreased superoxide dismutase 2 expression in pulmonary hypertension (PH), as well as trimethylation of histones H3K4 and H3K9 in congestive heart failure. 23480168 2013
CUI: C0018802
Disease: Congestive heart failure
Congestive heart failure
0.570 Biomarker disease CTD_human Deprivation of MKK7 in cardiomyocytes provokes heart failure in mice when exposed to pressure overload. 21284947 2011
CUI: C0018802
Disease: Congestive heart failure
Congestive heart failure
0.570 Biomarker disease CTD_human This study examined telomere biology in heart/muscle-specific manganese superoxide dismutase-deficient mice (H/M-SOD2(-/-)), which develop progressive congestive heart failure and exhibit pathology typical of dilated cardiomyopathy. 21195081 2011
CUI: C0018802
Disease: Congestive heart failure
Congestive heart failure
0.570 Biomarker disease CTD_human MnSOD protects against COX1-mediated endothelial dysfunction in chronic heart failure. 20304815 2010
CUI: C0018802
Disease: Congestive heart failure
Congestive heart failure
0.570 Biomarker disease CTD_human Myocardial subproteomic analysis of a constitutively active Rac1-expressing transgenic mouse with lethal myocardial hypertrophy. 16155095 2005
CUI: C0018802
Disease: Congestive heart failure
Congestive heart failure
0.570 Biomarker disease CTD_human Increased reactive oxygen species production and functional alterations in antioxidant enzymes in human failing myocardium. 16105639 2005
CUI: C0018802
Disease: Congestive heart failure
Congestive heart failure
0.570 Biomarker disease MGD