SOX2, SRY-box transcription factor 2, 6657

N. diseases: 503; N. variants: 23
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0007137
Disease: Squamous cell carcinoma
Squamous cell carcinoma
0.400 Biomarker disease BEFREE In addition, upregulated SOX2 was associated with advanced and metastatic tumors in OSCC patients and was responsible for the drug-resistance property of OSCC cells. 30981761 2019
CUI: C0007137
Disease: Squamous cell carcinoma
Squamous cell carcinoma
0.400 Biomarker disease BEFREE This may be because pathways enriched in the TrkB high expressers, like those involving oncogenes NFE2L2, PIK3CA, and SOX2, are known to have SCC anatomic site-specific effects on progression. 31221127 2019
CUI: C0007137
Disease: Squamous cell carcinoma
Squamous cell carcinoma
0.400 Biomarker disease BEFREE Combining gene targeting with chromatin immunoprecipitation sequencing (ChIP-seq) and transcriptomic analyses reveals that PITX1 cooperates with SOX2 and TRP63 to sustain an SCC-specific transcriptional feed-forward circuit that maintains TPC-renewal, while inhibiting KLF4 expression and preventing KLF4-dependent differentiation. 30713093 2019
CUI: C0007137
Disease: Squamous cell carcinoma
Squamous cell carcinoma
0.400 Biomarker disease BEFREE SOX2 and PCNA immunoreactivities in SCC had dot‑like staining patterns in the nuclei of partial and marginal cancer cells. 31257482 2019
CUI: C0007137
Disease: Squamous cell carcinoma
Squamous cell carcinoma
0.400 Biomarker disease BEFREE CDK7 inhibition as a promising therapeutic strategy for lung squamous cell carcinomas with a SOX2 amplification. 30838525 2019
CUI: C0007137
Disease: Squamous cell carcinoma
Squamous cell carcinoma
0.400 AlteredExpression disease BEFREE Label="METHODOLOGY">The immunohistochemical expression of SOX2 and podoplanin were evaluated in 60 cases of primary oral squamous cell carcinomas. 31508790 2019
CUI: C0007137
Disease: Squamous cell carcinoma
Squamous cell carcinoma
0.400 Biomarker disease BEFREE p63 and SOX2 Dictate Glucose Reliance and Metabolic Vulnerabilities in Squamous Cell Carcinomas. 31412252 2019
CUI: C0007137
Disease: Squamous cell carcinoma
Squamous cell carcinoma
0.400 AlteredExpression disease BEFREE The Hippo effector TAZ promotes cancer stemness by transcriptional activation of SOX2 in head neck squamous cell carcinoma. 31399556 2019
CUI: C0007137
Disease: Squamous cell carcinoma
Squamous cell carcinoma
0.400 AlteredExpression disease BEFREE In the current study we investigated podoplanin (PP) and SOX2 expression in normal squamous epithelium, in CIN 3 and in 16 CIN 3-like SCCs 11 of which also showed a conventional invasive component. 28319578 2018
CUI: C0007137
Disease: Squamous cell carcinoma
Squamous cell carcinoma
0.400 Biomarker disease BEFREE Here, epigenomic profilings of different types of SCCs reveal that TP63 and SOX2 cooperatively and lineage-specifically regulate long non-coding RNA (lncRNA) CCAT1 expression, through activation of its super-enhancers and promoter. 30190462 2018
CUI: C0007137
Disease: Squamous cell carcinoma
Squamous cell carcinoma
0.400 Biomarker disease BEFREE SOX2-silenced squamous cell carcinoma: a highly malignant form of esophageal cancer with SOX2 promoter hypermethylation. 28862264 2018
CUI: C0007137
Disease: Squamous cell carcinoma
Squamous cell carcinoma
0.400 Biomarker disease BEFREE SOX2 copy number increases have been frequently reported in various types of squamous cell cancer. 28700423 2018
CUI: C0007137
Disease: Squamous cell carcinoma
Squamous cell carcinoma
0.400 Biomarker disease BEFREE Our findings support a role for SOX2 in the progression of squamous dysplasia to SCC. 27490766 2018
CUI: C0007137
Disease: Squamous cell carcinoma
Squamous cell carcinoma
0.400 Biomarker disease BEFREE The transcription factor SOX2 has been identified as a lineage survival oncogene in squamous cell carcinoma and copy number gain is a common event in several human malignancies including head and neck cancer. 29596469 2018
CUI: C0007137
Disease: Squamous cell carcinoma
Squamous cell carcinoma
0.400 Biomarker disease BEFREE We propose that Oct3/4, Sox2 and Nanog are associated with tumor hypoxia characterized in oral SCC and that these factors may also contribute to the undifferentiated potency observed in oral SCC clinically. 28314267 2017
CUI: C0007137
Disease: Squamous cell carcinoma
Squamous cell carcinoma
0.400 Biomarker disease BEFREE Effect of 3q oncogenes SEC62 and SOX2 on lymphatic metastasis and clinical outcome of head and neck squamous cell carcinomas. 28002801 2017
CUI: C0007137
Disease: Squamous cell carcinoma
Squamous cell carcinoma
0.400 AlteredExpression disease BEFREE We propose that SOX2 acts as a transcriptional repressor of HPV16-LCR, decreasing the expression of <i>E6</i> and <i>E7</i> oncogenes in a SCC context. 28678184 2017
CUI: C0007137
Disease: Squamous cell carcinoma
Squamous cell carcinoma
0.400 Biomarker disease BEFREE The pooling analyses revealed that there were significant associations between SOX2 DNA amplification and clinical features of NSCLC, gender, smoking status, squamous cell cancer (SCC) histology, and differentiations. 27150062 2016
CUI: C0007137
Disease: Squamous cell carcinoma
Squamous cell carcinoma
0.400 AlteredExpression disease BEFREE Additionally, clinical results further revealed that Sox2 and Oct4 expression was inversely correlated with miR-145 in the tissues of areca quid chewing-associated OSCC patients. 27557511 2016
CUI: C0007137
Disease: Squamous cell carcinoma
Squamous cell carcinoma
0.400 GeneticVariation disease BEFREE Recurrent gain on chromosome 3q26 encompassing the gene locus for the transcription factor SOX2 is a frequent event in human squamous cell carcinoma, including head and neck squamous cell carcinoma (HNSCC). 26040981 2015
CUI: C0007137
Disease: Squamous cell carcinoma
Squamous cell carcinoma
0.400 AlteredExpression disease BEFREE Lin28B/Let-7 Regulates Expression of Oct4 and Sox2 and Reprograms Oral Squamous Cell Carcinoma Cells to a Stem-like State. 25858147 2015
CUI: C0007137
Disease: Squamous cell carcinoma
Squamous cell carcinoma
0.400 Biomarker disease BEFREE The identification of the SCC-associated interaction between SOX2 and p63 will enable deeper characterization the downstream targets of this interaction in SCC and normal squamous epithelial physiology. 24590290 2014
CUI: C0007137
Disease: Squamous cell carcinoma
Squamous cell carcinoma
0.400 Biomarker disease BEFREE We demonstrate that Sox2 is required for SCC growth in mouse and human, where it enhances Nrp1/Vegf signalling to promote the expansion of TICs along the tumour-stroma interface. 25077433 2014
CUI: C0007137
Disease: Squamous cell carcinoma
Squamous cell carcinoma
0.400 GeneticVariation disease BEFREE Multivariate analysis of overall survival indicated increased SOX2 gene copy number (P = 0.008), stage I-II (P<0.001), and adenocarcinoma or SCC histology (P = 0.016) as independent, favorable prognostic factors. 24736592 2014
CUI: C0007137
Disease: Squamous cell carcinoma
Squamous cell carcinoma
0.400 Biomarker disease BEFREE Recently, SOX2 has been identified as a potential lineage-specific oncogene in lung squamous cell carcinomas. 24743512 2014