SOX2, SRY-box transcription factor 2, 6657

N. diseases: 503; N. variants: 23
Disease: Esophageal Neoplasms ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0014859
Disease: Esophageal Neoplasms
Esophageal Neoplasms 		0.330 AlteredExpression group BEFREE Here we showed that in esophageal cancer cell lines the levels of SOX2 proteins are not directly correlated to the copy numbers of SOX2 genes and are strongly influenced by proteostasis. 30894683 2019
CUI: C0014859
Disease: Esophageal Neoplasms
Esophageal Neoplasms 		0.330 GeneticVariation group BEFREE SOX2-silenced squamous cell carcinoma: a highly malignant form of esophageal cancer with SOX2 promoter hypermethylation. 28862264 2018
CUI: C0014859
Disease: Esophageal Neoplasms
Esophageal Neoplasms 		0.330 AlteredExpression group BEFREE miR-625 has been reported to exhibit abnormal expression in esophageal cancer (EC), but the mechanism and functions of miR-625 in esophageal cancer remain unclear. miR-625 down-regulation and Sox2 up-regulation were validated by qRT-PCR in 158 EC samples. 24508466 2014
CUI: C0014859
Disease: Esophageal Neoplasms
Esophageal Neoplasms 		0.330 GenomicAlterations group CGI