Glioma
|
0.600 |
Biomarker
|
disease |
BEFREE |
Both OPN-a Mu and -c Mu promoted glioma cell invasion through alteration of the levels of uPA, MMP-2, and MMP-9 expressions and the activities of MMP-2 and MMP-9 via activation PI-3K/AKT/NF-kappaB signaling pathway.
|
20511184 |
2010 |
Glioma
|
0.600 |
Biomarker
|
disease |
BEFREE |
We have recently demonstrated the importance of osteopontin (OPN) in the acquisition/maintenance of stemness characters and tumorigenicity of glioma initiating cells.
|
27563812 |
2016 |
Glioma
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Analysis of the RNA-Seq data from The Cancer Genome Atlas database showed that the increased SPP1 mRNA expression in lower-grade glioma was significantly associated with poor survival outcomes in patients with lower-grade glioma.
|
31295606 |
2019 |
Glioma
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Downregulation of osteopontin enhances the sensitivity of glioma U251 cells to temozolomide and cisplatin by targeting the NF-κB/Bcl‑2 pathway.
|
25405848 |
2015 |
Glioma
|
0.600 |
Biomarker
|
disease |
BEFREE |
These strategies allow us to define an important role of OPN in conferring cancer hallmarks, which can be further applied to assess the functional roles of other candidate genes in glioma.
|
27198662 |
2016 |
Glioma
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
We reveal that SPP1 is overexpressed in glioma initiating cells defined by high rhodamine 123 efflux, sphere forming capacity and stemness marker expression.
|
28030801 |
2017 |
Glioma
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
We found significant evidence of an association between SPP1 promoter polymorphisms and glioma risk.
|
20505679 |
2010 |
Glioma
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Glioma-associated microglia/macrophages display an expression profile different from M1 and M2 polarization and highly express Gpnmb and Spp1.
|
25658639 |
2015 |
Glioma
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Polymorphism -433 C>T of the Osteopontin gene is associated with the susceptibility to develop gliomas and their prognosis in a Chinese cohort.
|
25277531 |
2014 |
Glioma
|
0.600 |
Biomarker
|
disease |
BEFREE |
To elucidate the role of OPN in the process of glioma angiogenesis, endothelial progenitor cells (EPCs) were treated with conditioned media of human glioma SHG44 cells overexpressing OPN.
|
21616556 |
2011 |
Glioma
|
0.600 |
Biomarker
|
disease |
BEFREE |
This is the first demonstration that OPN inhibition blocks glioma tumor growth, making this invasion-related protein an attractive target for glioma therapy.
|
19609945 |
2010 |
Glioma
|
0.600 |
Biomarker
|
disease |
BEFREE |
These infiltrating macrophages secrete SPP1, which sustains glioma cell survival and stimulates angiogenesis.
|
31185211 |
2019 |
Glioma
|
0.600 |
Biomarker
|
disease |
BEFREE |
OPN expression increases in correlation to the glioma malignancy from 4.5 ± 1.8% (I) to 12.3 ± 1.2% of OPN+ cells (III).
|
30140373 |
2018 |
Glioma
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Thrombin-cleaved fragments of osteopontin are overexpressed in malignant glial tumors and provide a molecular niche with survival advantage.
|
23204518 |
2013 |
Glioma
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
We also isolated and sequenced three types of splice variants in OPN from human glioma cell lines through polymerase chain reaction.
|
7837791 |
1995 |
Glioma
|
0.600 |
Biomarker
|
disease |
BEFREE |
Both tumor-derived and host-derived OPN were critical for glioma development.
|
30307407 |
2019 |
Kidney Calculi
|
0.600 |
Biomarker
|
disease |
BEFREE |
The results advocate possible association of osteopontin with ER stress, thus suggesting that the ER could be a new target for developing therapeutic regimes for kidney stones.
|
28442375 |
2017 |
Kidney Calculi
|
0.600 |
Biomarker
|
disease |
BEFREE |
We suggest that such genetic findings may help to clarify the function of OPN in nephrolithiasis.
|
17519954 |
2007 |
Kidney Calculi
|
0.600 |
Biomarker
|
disease |
BEFREE |
RT-PCR analysis and immunocytochemistry of NRK-52E cells revealed the up-regulation of inflammatory and stress biomarkers OPN and HSP-70, respectively, in response to COM toxicity; which diminished significantly in the presence of kidney stone matrix proteins.
|
29054323 |
2017 |
Kidney Calculi
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
These results are the first to demonstrate the existence of T-593A promoter polymorphism of the OPN gene and significant association with risk of developing nephrolithiasis.
|
21044748 |
2010 |
Kidney Calculi
|
0.600 |
Biomarker
|
disease |
BEFREE |
To further investigate the role of Opn, we used a double-knockout strategy, which provides evidence that loss of Opn worsens the nephrocalcinosis and nephrolithiasis observed in these mice on a high-phosphate diet.
|
27784695 |
2017 |
Kidney Calculi
|
0.600 |
Biomarker
|
disease |
BEFREE |
Inhibitive Effects of Huashi Pill on Formation of Renal Stones by Modulating Urine Biochemical Indexes and Osteopontin in Renal Stone Rat Models.
|
31690714 |
2019 |
Kidney Calculi
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Taken together, our findings suggest that gallotannin can contribute to nephrolithiasis prevention via direct effects on renal epithelial cells including suppression of COM binding and MCP-1 and OPN expression, along with augmenting antioxidant activity.
|
22466558 |
2012 |
Kidney Calculi
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Activation of liver X receptor suppresses osteopontin expression and ameliorates nephrolithiasis.
|
30623435 |
2019 |
Kidney Calculi
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
The aim of the study was assessment of four selected macromolecules level: osteopontin, calgranulin, uromodulin and bikunin in fresh morning urine sample in children with nephrolithiasis in the course of idiopathic hypercalciuria.
|
29353465 |
2018 |