SPP1, secreted phosphoprotein 1, 6696

N. diseases: 824; N. variants: 13
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0017638
Disease: Glioma
Glioma
0.600 Biomarker disease BEFREE Both OPN-a Mu and -c Mu promoted glioma cell invasion through alteration of the levels of uPA, MMP-2, and MMP-9 expressions and the activities of MMP-2 and MMP-9 via activation PI-3K/AKT/NF-kappaB signaling pathway. 20511184 2010
CUI: C0017638
Disease: Glioma
Glioma
0.600 Biomarker disease BEFREE We have recently demonstrated the importance of osteopontin (OPN) in the acquisition/maintenance of stemness characters and tumorigenicity of glioma initiating cells. 27563812 2016
CUI: C0017638
Disease: Glioma
Glioma
0.600 AlteredExpression disease BEFREE Analysis of the RNA-Seq data from The Cancer Genome Atlas database showed that the increased SPP1 mRNA expression in lower-grade glioma was significantly associated with poor survival outcomes in patients with lower-grade glioma. 31295606 2019
CUI: C0017638
Disease: Glioma
Glioma
0.600 AlteredExpression disease BEFREE Downregulation of osteopontin enhances the sensitivity of glioma U251 cells to temozolomide and cisplatin by targeting the NF-κB/Bcl‑2 pathway. 25405848 2015
CUI: C0017638
Disease: Glioma
Glioma
0.600 Biomarker disease BEFREE These strategies allow us to define an important role of OPN in conferring cancer hallmarks, which can be further applied to assess the functional roles of other candidate genes in glioma. 27198662 2016
CUI: C0017638
Disease: Glioma
Glioma
0.600 AlteredExpression disease BEFREE We reveal that SPP1 is overexpressed in glioma initiating cells defined by high rhodamine 123 efflux, sphere forming capacity and stemness marker expression. 28030801 2017
CUI: C0017638
Disease: Glioma
Glioma
0.600 GeneticVariation disease BEFREE We found significant evidence of an association between SPP1 promoter polymorphisms and glioma risk. 20505679 2010
CUI: C0017638
Disease: Glioma
Glioma
0.600 AlteredExpression disease BEFREE Glioma-associated microglia/macrophages display an expression profile different from M1 and M2 polarization and highly express Gpnmb and Spp1. 25658639 2015
CUI: C0017638
Disease: Glioma
Glioma
0.600 GeneticVariation disease BEFREE Polymorphism -433 C>T of the Osteopontin gene is associated with the susceptibility to develop gliomas and their prognosis in a Chinese cohort. 25277531 2014
CUI: C0017638
Disease: Glioma
Glioma
0.600 Biomarker disease BEFREE To elucidate the role of OPN in the process of glioma angiogenesis, endothelial progenitor cells (EPCs) were treated with conditioned media of human glioma SHG44 cells overexpressing OPN. 21616556 2011
CUI: C0017638
Disease: Glioma
Glioma
0.600 Biomarker disease BEFREE This is the first demonstration that OPN inhibition blocks glioma tumor growth, making this invasion-related protein an attractive target for glioma therapy. 19609945 2010
CUI: C0017638
Disease: Glioma
Glioma
0.600 Biomarker disease BEFREE These infiltrating macrophages secrete SPP1, which sustains glioma cell survival and stimulates angiogenesis. 31185211 2019
CUI: C0017638
Disease: Glioma
Glioma
0.600 Biomarker disease BEFREE OPN expression increases in correlation to the glioma malignancy from 4.5 ± 1.8% (I) to 12.3 ± 1.2% of OPN+ cells (III). 30140373 2018
CUI: C0017638
Disease: Glioma
Glioma
0.600 AlteredExpression disease BEFREE Thrombin-cleaved fragments of osteopontin are overexpressed in malignant glial tumors and provide a molecular niche with survival advantage. 23204518 2013
CUI: C0017638
Disease: Glioma
Glioma
0.600 GeneticVariation disease BEFREE We also isolated and sequenced three types of splice variants in OPN from human glioma cell lines through polymerase chain reaction. 7837791 1995
CUI: C0017638
Disease: Glioma
Glioma
0.600 Biomarker disease BEFREE Both tumor-derived and host-derived OPN were critical for glioma development. 30307407 2019
CUI: C0022650
Disease: Kidney Calculi
Kidney Calculi
0.600 Biomarker disease BEFREE The results advocate possible association of osteopontin with ER stress, thus suggesting that the ER could be a new target for developing therapeutic regimes for kidney stones. 28442375 2017
CUI: C0022650
Disease: Kidney Calculi
Kidney Calculi
0.600 Biomarker disease BEFREE We suggest that such genetic findings may help to clarify the function of OPN in nephrolithiasis. 17519954 2007
CUI: C0022650
Disease: Kidney Calculi
Kidney Calculi
0.600 Biomarker disease BEFREE RT-PCR analysis and immunocytochemistry of NRK-52E cells revealed the up-regulation of inflammatory and stress biomarkers OPN and HSP-70, respectively, in response to COM toxicity; which diminished significantly in the presence of kidney stone matrix proteins. 29054323 2017
CUI: C0022650
Disease: Kidney Calculi
Kidney Calculi
0.600 GeneticVariation disease BEFREE These results are the first to demonstrate the existence of T-593A promoter polymorphism of the OPN gene and significant association with risk of developing nephrolithiasis. 21044748 2010
CUI: C0022650
Disease: Kidney Calculi
Kidney Calculi
0.600 Biomarker disease BEFREE To further investigate the role of Opn, we used a double-knockout strategy, which provides evidence that loss of Opn worsens the nephrocalcinosis and nephrolithiasis observed in these mice on a high-phosphate diet. 27784695 2017
CUI: C0022650
Disease: Kidney Calculi
Kidney Calculi
0.600 Biomarker disease BEFREE Inhibitive Effects of Huashi Pill on Formation of Renal Stones by Modulating Urine Biochemical Indexes and Osteopontin in Renal Stone Rat Models. 31690714 2019
CUI: C0022650
Disease: Kidney Calculi
Kidney Calculi
0.600 AlteredExpression disease BEFREE Taken together, our findings suggest that gallotannin can contribute to nephrolithiasis prevention via direct effects on renal epithelial cells including suppression of COM binding and MCP-1 and OPN expression, along with augmenting antioxidant activity. 22466558 2012
CUI: C0022650
Disease: Kidney Calculi
Kidney Calculi
0.600 AlteredExpression disease BEFREE Activation of liver X receptor suppresses osteopontin expression and ameliorates nephrolithiasis. 30623435 2019
CUI: C0022650
Disease: Kidney Calculi
Kidney Calculi
0.600 AlteredExpression disease BEFREE The aim of the study was assessment of four selected macromolecules level: osteopontin, calgranulin, uromodulin and bikunin in fresh morning urine sample in children with nephrolithiasis in the course of idiopathic hypercalciuria. 29353465 2018