Kidney Calculi
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
SPP1 polymorphisms were found to be associated with nephrolithiasis and it may be suggested that SPP1 gene polymorphism could be a useful marker for evaluation of the early genetic risk factor in childhood nephrolithiasis.
|
23235966 |
2012 |
Kidney Calculi
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Activation of liver X receptor suppresses osteopontin expression and ameliorates nephrolithiasis.
|
30623435 |
2019 |
Kidney Calculi
|
0.600 |
Biomarker
|
disease |
LHGDN |
Apatite plaque particles in inner medulla of kidneys of calcium oxalate stone formers: osteopontin localization.
|
15954903 |
2005 |
Kidney Calculi
|
0.600 |
Biomarker
|
disease |
BEFREE |
Based on these data, it is proposed that during urolithiasis, secretion of osteopontin (uropontin) and osteocalcin (or osteocalcin-related gene/protein), and the subsequent incorporation of these proteins into kidney stone matrix, may influence the nucleation, growth processes, aggregation, and/or tubular adhesion of renal calculi in mammalian kidneys.
|
8619372 |
1995 |
Kidney Calculi
|
0.600 |
Biomarker
|
disease |
BEFREE |
Calcium oxalate dihydrate (COD) mineral and the urinary protein osteopontin/uropontin (OPN) are commonly found in kidney stones.
|
19581305 |
2009 |
Kidney Calculi
|
0.600 |
Biomarker
|
disease |
RGD |
Effect of NADPH oxidase inhibition on the expression of kidney injury molecule and calcium oxalate crystal deposition in hydroxy-L-proline-induced hyperoxaluria in the male Sprague-Dawley rats.
|
21378157 |
2011 |
Kidney Calculi
|
0.600 |
Biomarker
|
disease |
BEFREE |
Here, we investigated the effects of different phosphorylated states of a synthesized peptide of OPN (the ASARM peptide; acidic, serine- and aspartate-rich motif) on calcium oxalate dihydrate (COD) crystals, a major mineral phase of kidney stones.
|
30016645 |
2018 |
Kidney Calculi
|
0.600 |
Biomarker
|
disease |
BEFREE |
Here, we quantitatively investigate the role of phosphorylation in interactions with calcium oxalate monohydrate crystals (COM), using synthetic peptides corresponding to the sequence 220-235 in osteopontin, a major inhibitor of kidney stone-related COM formation.
|
30569197 |
2019 |
Kidney Calculi
|
0.600 |
Biomarker
|
disease |
BEFREE |
In addition, OPN is associated with renal stones, but whether it acts as a promoter or inhibitor of stone formation is controversial.
|
11703581 |
2001 |
Kidney Calculi
|
0.600 |
Biomarker
|
disease |
BEFREE |
Inhibitive Effects of Huashi Pill on Formation of Renal Stones by Modulating Urine Biochemical Indexes and Osteopontin in Renal Stone Rat Models.
|
31690714 |
2019 |
Kidney Calculi
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Metformin prevents nephrolithiasis formation by inhibiting the expression of OPN and MCP-1 in vitro and in vivo.
|
30720053 |
2019 |
Kidney Calculi
|
0.600 |
Biomarker
|
disease |
CTD_human |
Phosphate is a specific signal for induction of osteopontin gene expression.
|
10890885 |
2000 |
Kidney Calculi
|
0.600 |
Biomarker
|
disease |
BEFREE |
RT-PCR analysis and immunocytochemistry of NRK-52E cells revealed the up-regulation of inflammatory and stress biomarkers OPN and HSP-70, respectively, in response to COM toxicity; which diminished significantly in the presence of kidney stone matrix proteins.
|
29054323 |
2017 |
Kidney Calculi
|
0.600 |
Biomarker
|
disease |
CTD_human |
Structure and expression of the mRNA encoding urinary stone protein (osteopontin).
|
8325891 |
1993 |
Kidney Calculi
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Taken together, our findings suggest that gallotannin can contribute to nephrolithiasis prevention via direct effects on renal epithelial cells including suppression of COM binding and MCP-1 and OPN expression, along with augmenting antioxidant activity.
|
22466558 |
2012 |
Kidney Calculi
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
The aim of the study was assessment of four selected macromolecules level: osteopontin, calgranulin, uromodulin and bikunin in fresh morning urine sample in children with nephrolithiasis in the course of idiopathic hypercalciuria.
|
29353465 |
2018 |
Kidney Calculi
|
0.600 |
Biomarker
|
disease |
BEFREE |
The Effects of Melatonin on Ethylene Glycol-induced Nephrolithiasis: Role on Osteopontin mRNA Gene Expression.
|
27717860 |
2017 |
Kidney Calculi
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
The purpose of this study is to evaluate the correlation between urinary OPN level and kidney stone formation and effect of nutrition on OPN level in nephrolithiasis.
|
30114399 |
2018 |
Kidney Calculi
|
0.600 |
Biomarker
|
disease |
BEFREE |
The results advocate possible association of osteopontin with ER stress, thus suggesting that the ER could be a new target for developing therapeutic regimes for kidney stones.
|
28442375 |
2017 |
Kidney Calculi
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
These results are the first to demonstrate the existence of T-593A promoter polymorphism of the OPN gene and significant association with risk of developing nephrolithiasis.
|
21044748 |
2010 |
Kidney Calculi
|
0.600 |
Biomarker
|
disease |
BEFREE |
To further investigate the role of Opn, we used a double-knockout strategy, which provides evidence that loss of Opn worsens the nephrocalcinosis and nephrolithiasis observed in these mice on a high-phosphate diet.
|
27784695 |
2017 |
Kidney Calculi
|
0.600 |
Biomarker
|
disease |
BEFREE |
We previously reported the potential therapeutic role of osteopontin (OPN) and macrophages in CaOx kidney stone formation, discovered using genome-recombined mice and genome-wide analyses.
|
27297950 |
2017 |
Kidney Calculi
|
0.600 |
Biomarker
|
disease |
BEFREE |
We suggest that such genetic findings may help to clarify the function of OPN in nephrolithiasis.
|
17519954 |
2007 |