|
Glioma
|
0.600 |
Biomarker
|
disease |
BEFREE |
To elucidate the role of OPN in the process of glioma angiogenesis, endothelial progenitor cells (EPCs) were treated with conditioned media of human glioma SHG44 cells overexpressing OPN.
|
21616556 |
2011 |
|
Kidney Calculi
|
0.600 |
Biomarker
|
disease |
RGD |
Effect of NADPH oxidase inhibition on the expression of kidney injury molecule and calcium oxalate crystal deposition in hydroxy-L-proline-induced hyperoxaluria in the male Sprague-Dawley rats.
|
21378157 |
2011 |
|
Glioma
|
0.600 |
Biomarker
|
disease |
BEFREE |
Both OPN-a Mu and -c Mu promoted glioma cell invasion through alteration of the levels of uPA, MMP-2, and MMP-9 expressions and the activities of MMP-2 and MMP-9 via activation PI-3K/AKT/NF-kappaB signaling pathway.
|
20511184 |
2010 |
|
Glioma
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
We found significant evidence of an association between SPP1 promoter polymorphisms and glioma risk.
|
20505679 |
2010 |
|
Glioma
|
0.600 |
Biomarker
|
disease |
BEFREE |
This is the first demonstration that OPN inhibition blocks glioma tumor growth, making this invasion-related protein an attractive target for glioma therapy.
|
19609945 |
2010 |
|
Kidney Calculi
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
These results are the first to demonstrate the existence of T-593A promoter polymorphism of the OPN gene and significant association with risk of developing nephrolithiasis.
|
21044748 |
2010 |
|
Kidney Calculi
|
0.600 |
Biomarker
|
disease |
BEFREE |
Calcium oxalate dihydrate (COD) mineral and the urinary protein osteopontin/uropontin (OPN) are commonly found in kidney stones.
|
19581305 |
2009 |
|
Kidney Calculi
|
0.600 |
Biomarker
|
disease |
BEFREE |
We suggest that such genetic findings may help to clarify the function of OPN in nephrolithiasis.
|
17519954 |
2007 |
|
Glioma
|
0.600 |
Biomarker
|
disease |
RGD |
Based on these findings, we conclude that OPN overexpression in ENU-induced gliomas occurs within a specific subset of intratumoral glial fibrillary acidic protein-positive cells and becomes evident at the stage of tumor progression.
|
16651633 |
2006 |
|
Glioma
|
0.600 |
Biomarker
|
disease |
CTD_human |
Based on these findings, we conclude that OPN overexpression in ENU-induced gliomas occurs within a specific subset of intratumoral glial fibrillary acidic protein-positive cells and becomes evident at the stage of tumor progression.
|
16651633 |
2006 |
|
Kidney Calculi
|
0.600 |
Biomarker
|
disease |
LHGDN |
Apatite plaque particles in inner medulla of kidneys of calcium oxalate stone formers: osteopontin localization.
|
15954903 |
2005 |
|
Kidney Calculi
|
0.600 |
Biomarker
|
disease |
BEFREE |
In addition, OPN is associated with renal stones, but whether it acts as a promoter or inhibitor of stone formation is controversial.
|
11703581 |
2001 |
|
Kidney Calculi
|
0.600 |
Biomarker
|
disease |
CTD_human |
Phosphate is a specific signal for induction of osteopontin gene expression.
|
10890885 |
2000 |
|
Glioma
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
We also isolated and sequenced three types of splice variants in OPN from human glioma cell lines through polymerase chain reaction.
|
7837791 |
1995 |
|
Kidney Calculi
|
0.600 |
Biomarker
|
disease |
BEFREE |
Based on these data, it is proposed that during urolithiasis, secretion of osteopontin (uropontin) and osteocalcin (or osteocalcin-related gene/protein), and the subsequent incorporation of these proteins into kidney stone matrix, may influence the nucleation, growth processes, aggregation, and/or tubular adhesion of renal calculi in mammalian kidneys.
|
8619372 |
1995 |
|
Kidney Calculi
|
0.600 |
Biomarker
|
disease |
CTD_human |
Structure and expression of the mRNA encoding urinary stone protein (osteopontin).
|
8325891 |
1993 |
|
Malignant Glioma
|
0.560 |
Biomarker
|
disease |
BEFREE |
Association of Notch-1, osteopontin and stem-like cells in ENU-glioma malignant process.
|
30140373 |
2018 |
|
Malignant Glioma
|
0.560 |
Biomarker
|
disease |
BEFREE |
The literature review suggests that OPN may play important roles in the development and progression of selected cancers of children and young adults, including acute lymphoblastic leukemia, malignant gliomas, AT/RT and Langerhans cell histiocytosis.
|
28326824 |
2017 |
|
Malignant Glioma
|
0.560 |
AlteredExpression
|
disease |
BEFREE |
Our findings show re-activation of the embryonic-type transcriptional regulation of SPP1 in malignant gliomas and point to the importance of SPP1-CD44 interactions in self-renewal and pluripotency glioma initiating cells.
|
28030801 |
2017 |
|
Malignant Glioma
|
0.560 |
AlteredExpression
|
disease |
BEFREE |
Osteopontin and splice variant expression level in human malignant glioma: radiobiologic effects and prognosis after radiotherapy.
|
23891093 |
2013 |
|
Malignant Glioma
|
0.560 |
AlteredExpression
|
disease |
BEFREE |
Five potential markers (CD44 antigen (CD44), growth arrest and DNA-damage-inducible, alpha (GADD45A), fibronectin 1 (FN1), CD63 antigen (CD63) and secreted phosphoprotein 1 (SPP1)) showed expression patterns that correlated significantly with malignant glioma.
|
20150644 |
2010 |
|
Malignant Glioma
|
0.560 |
Biomarker
|
disease |
RGD |
Osteopontin expression in intratumoral astrocytes marks tumor progression in gliomas induced by prenatal exposure to N-ethyl-N-nitrosourea.
|
16651633 |
2006 |
|
Malignant Glioma
|
0.560 |
Biomarker
|
disease |
CTD_human |
Osteopontin expression in intratumoral astrocytes marks tumor progression in gliomas induced by prenatal exposure to N-ethyl-N-nitrosourea.
|
16651633 |
2006 |
|
Malignant Glioma
|
0.560 |
Biomarker
|
disease |
BEFREE |
Elucidation of regulatory mechanisms for OPN induction in glioma cells should facilitate rational design of novel therapeutics for human malignant gliomas.
|
9615723 |
1998 |
|
Lupus Erythematosus, Systemic
|
0.500 |
Biomarker
|
disease |
BEFREE |
OPN production has been associated with several pathological conditions, including autoimmune diseases (e.g. lupus, multiple sclerosis and rheumatoid arthritis) and cancer.
|
31126876 |
2019 |