Arteriosclerosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
In this study, we investigated the effects of oral treatment with paricalcitol, a potent vitamin D receptor activator, on arterial stiffness and osteopontin, a marker of atherosclerosis, in hypertensive patients with chronic kidney disease (CKD) and secondary hyperparathyroidism.
|
29305902 |
2020 |
Arteriosclerosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Recent studies showed that key proteins of bone metabolism, such as osteoprotegerin (OPG) and osteopontin (OPN), are also involved in vascular atherosclerosis and calcifications.
|
30791743 |
2019 |
Arteriosclerosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
OPN underlies several cardiovascular pathologies, including atherosclerosis and cardiac adverse remodeling.
|
30897705 |
2019 |
Arteriosclerosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
OPN identifies progression of atherosclerosis in persons free of ASCVD at baseline and may be a useful predictive tool to guide ASCVD prevention management.
|
30711632 |
2019 |
Arteriosclerosis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Circulating Osteopontin (OPN) levels have been also shown to have a potential role in the development of atherosclerosis.
|
31036794 |
2019 |
Arteriosclerosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Osteoprotegerin and osteopontin have recently emerged as key factors in both vascular remodelling and atherosclerosis progression.
|
31642412 |
2019 |
Arteriosclerosis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
FFC displayed increased atherosclerosis and gene expression of inflammatory markers, including vascular cell adhesion molecule 1 (VCAM-1), cluster of differentiation 68 (CD68), matrix metalloproteinase 9 (MMP9), cathepsin K (CTSK) and secreted phosphoprotein 1 (SPP1) compared to Control and DNO (all, p < 0.05).
|
31004968 |
2019 |
Arteriosclerosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Here, we focused on the role of osteopontin (OPN) as biomarker of subclinical atherosclerosis associated with SLE.
|
30767212 |
2019 |
Arteriosclerosis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Herein, we show that teniposide protected SMC phenotype switching during atherosclerosis by enhancing expression of smooth muscle α-actin (SMA) while reducing osteopontin (OPN) expression in aortic lesion plaques.
|
30409428 |
2018 |
Arteriosclerosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Osteopontin (OPN) has been demonstrated to participate in the occurrence of atherosclerosis, inflammation, as well as the adhesion and migration of cells.
|
28978514 |
2018 |
Arteriosclerosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Phosphoprotein 1 (osteopontin) gene (rs4754) affects markers of subclinical atherosclerosis in patients with type 2 diabetes mellitus.
|
28990744 |
2018 |
Arteriosclerosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
The aim of the study was to test the hypothesis that OPN could be a potential marker for micro-vascular complications in children and adolescents with T1DM and we assessed its relation to carotid and aortic intima media thickness (CIMT and AIMT) as non-invasive index for subclinical atherosclerosis.
|
29687557 |
2018 |
Arteriosclerosis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Therefore, restoring Hes-1 expression and inhibiting OPN expression may be a promising strategy to prevent vulnerable plaque formation in patients with atherosclerosis.
|
28420872 |
2017 |
Arteriosclerosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
We also revealed a NR6A1-CREB-SPP1 axis that serves as a regulatory mechanism for atherosclerosis and restenosis.
|
26546462 |
2015 |
Arteriosclerosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Evidence from several genetic mouse models suggests that OPN is an enhancer of atherosclerosis.
|
25128758 |
2014 |
Arteriosclerosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Endothelial-derived osteopontin may contribute to inflammation in smokers, and may also contribute to atherosclerosis and cardiovascular disease-related processes.
|
22978720 |
2012 |
Arteriosclerosis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
NPP1 and OPN expression levels positively correlated with the degree of plaque calcification (R= 0.54, P= 0.00019 and R= 0.46, P= 0.017, respectively) and with risk factors of atherosclerosis.
|
20015201 |
2011 |
Arteriosclerosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Osteopontin (OPN) is a proinflammatory mediator involved in tissue remodeling that plays a role in atherosclerosis and diabetes.
|
17595250 |
2007 |
Arteriosclerosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Osteopontin (OPN) is a proinflammatory cytokine implicated in the chemoattraction of monocytes and the development of atherosclerosis.
|
17360982 |
2007 |
Arteriosclerosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
In addition, OPN not only promotes arteriosclerosis but is also closely associated with angiogenesis.
|
17136480 |
2007 |
Arteriosclerosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
The OPN and MCP-1 genes, coding for 2 cytokines with known roles in atherosclerosis, may contribute to increased carotid IMT and warrant further study.
|
16741188 |
2006 |
Arteriosclerosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Given the significant role of both MGP and SPP1 in arteriosclerosis, further research in higher risk, older populations are needed to determine fully the way in which MGP and SPP1 polymorphisms are associated with disease.
|
15744522 |
2005 |
Arteriosclerosis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Osteopontin expression is related to urinary stone formation and several diseases associated with calcification such as atherosclerosis, breast cancer, and meningioma.
|
12142743 |
2002 |
Arteriosclerosis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
From these observations, we concluded that pure atmospheric pressure directly promotes an expression of OPN in HASMC, with these results also suggesting that high blood pressure-mediated mechanical compression is involved in the process of atherosclerosis and remodeling via OPN expression in HASMC.
|
11327728 |
2001 |
Arteriosclerosis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
As OPN mRNA-expressing macrophages surrounded the atheromatous plaques, and as the level of OPN mRNA expression increased as atherosclerosis advanced, it is possible that OPN plays a role in the calcification of atheromatous plaques.
|
8213995 |
1993 |