Muscular Dystrophy, Duchenne
|
0.100 |
Biomarker
|
disease |
BEFREE |
We previously showed that Spp1 exacerbates the DMD phenotype in the mdx mouse model by promoting fibrosis and by skewing macrophage polarization.
|
31411676 |
2019 |
Muscular Dystrophy, Duchenne
|
0.100 |
Biomarker
|
disease |
BEFREE |
Two genetic modifiers of Duchenne Muscular Dystrophy implicate the transforming growth factor β (TGFβ) pathway, osteopontin encoded by the SPP1 gene and latent TGFβ binding protein 4 (LTBP4).
|
29065150 |
2017 |
Muscular Dystrophy, Duchenne
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Our study shows a strong effect of the rs28357094 G allele in increasing OPN expression in the presence of deflazacort, and adds to the evidence that rs28357094 polymorphism may predict response to glucocorticoids in DMD.
|
28595270 |
2017 |
Muscular Dystrophy, Duchenne
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Osteopontin (OPN) polymorphisms are associated with muscle size and modify disease progression in Duchenne muscular dystrophy (DMD).
|
28745831 |
2017 |
Muscular Dystrophy, Duchenne
|
0.100 |
Biomarker
|
disease |
BEFREE |
This knowledge is essential for the design of future therapeutic interventions for muscular dystrophies that aim at targeting inflammation, especially that osteopontin inhibition has been suggested for Duchenne muscular dystrophy therapy.
|
28281577 |
2017 |
Muscular Dystrophy, Duchenne
|
0.100 |
Biomarker
|
disease |
BEFREE |
Common single nucleotide polymorphisms (SNPs) in candidate genes (SPP1, encoding osteopontin, and LTBP4, encoding latent transforming growth factor β [TGFβ]-binding protein 4) have been established as DMD modifiers.
|
27745838 |
2016 |
Muscular Dystrophy, Duchenne
|
0.100 |
Biomarker
|
disease |
BEFREE |
Most notably, animal model-derived data were translated to DMD and support use of BDNF and SPP1 as biomarkers for cardiac and skeletal muscle involvement, respectively.
|
26672735 |
2016 |
Muscular Dystrophy, Duchenne
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
We aimed to determine if polymorphisms previously associated with age at loss of independent ambulation (LoA) in DMD (rs28357094 in the SPP1 promoter, rs10880 and the VTTT/IAAM haplotype in LTBP4) also modify DCM onset.
|
26513582 |
2015 |
Muscular Dystrophy, Duchenne
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
We studied the effects of LTBP4 and SPP1 polymorphisms on age at loss of ambulation (LoA) in a multiethnic Duchenne muscular dystrophy (DMD) cohort.
|
25641372 |
2015 |
Muscular Dystrophy, Duchenne
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Validation of genetic modifiers for Duchenne muscular dystrophy: a multicentre study assessing SPP1 and LTBP4 variants.
|
25476005 |
2015 |
Muscular Dystrophy, Duchenne
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
This results in significantly greater expression of the pro-inflammatory OPN cytokine during tissue remodeling in response to challenge in G allele carriers, promoting muscle hypertrophy in normal females, but increased damage in DMD patients.
|
24626632 |
2014 |
Muscular Dystrophy, Duchenne
|
0.100 |
Biomarker
|
disease |
BEFREE |
Our findings suggest that OPN mediates inflammatory changes in DMD and that TGFB signalling has a role in the complex regulation of osteopontin expression.
|
22431140 |
2012 |
Muscular Dystrophy, Duchenne
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Importance of SPP1 genotype as a covariate in clinical trials in Duchenne muscular dystrophy.
|
22744661 |
2012 |
Muscular Dystrophy, Duchenne
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
SPP1 genotype is a determinant of disease severity in Duchenne muscular dystrophy.
|
21178099 |
2011 |
Muscular Dystrophy, Duchenne
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Muscle biopsies from individuals with DMD also had elevated OPN levels.
|
19451692 |
2009 |