Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0022650
Disease: Kidney Calculi
Kidney Calculi
0.370 AlteredExpression disease BEFREE Taken together, our findings suggest that gallotannin can contribute to nephrolithiasis prevention via direct effects on renal epithelial cells including suppression of COM binding and MCP-1 and OPN expression, along with augmenting antioxidant activity. 22466558 2012
CUI: C0022650
Disease: Kidney Calculi
Kidney Calculi
0.370 GeneticVariation disease BEFREE Association between the T-593A and C6982T polymorphisms of the osteopontin gene and risk of developing nephrolithiasis. 21044748 2011
CUI: C0022650
Disease: Kidney Calculi
Kidney Calculi
0.370 Biomarker disease BEFREE Calcium oxalate dihydrate (COD) mineral and the urinary protein osteopontin/uropontin (OPN) are commonly found in kidney stones. 19581305 2009
CUI: C0022650
Disease: Kidney Calculi
Kidney Calculi
0.370 GeneticVariation disease BEFREE Association of osteopontin gene haplotypes with nephrolithiasis. 17519954 2007
CUI: C0022650
Disease: Kidney Calculi
Kidney Calculi
0.370 Biomarker disease LHGDN osteopontin is one of the crystal-associated urine proteins involved in the formation of the organic layers of the plaque particles in kidney stones 15954903 2005
CUI: C0022650
Disease: Kidney Calculi
Kidney Calculi
0.370 Biomarker disease BEFREE In addition, OPN is associated with renal stones, but whether it acts as a promoter or inhibitor of stone formation is controversial. 11703581 2002
CUI: C0022650
Disease: Kidney Calculi
Kidney Calculi
0.370 Biomarker disease CTD_human Phosphate is a specific signal for induction of osteopontin gene expression. 10890885 2000
CUI: C0022650
Disease: Kidney Calculi
Kidney Calculi
0.370 Biomarker disease BEFREE Ultrastructural immunodetection of osteopontin and osteocalcin as major matrix components of renal calculi. 8619372 1996
CUI: C0022650
Disease: Kidney Calculi
Kidney Calculi
0.370 Biomarker disease CTD_human Structure and expression of the mRNA encoding urinary stone protein (osteopontin). 8325891 1993