SPP1, secreted phosphoprotein 1, 6696

N. diseases: 824; N. variants: 13
Disease: Lung Neoplasms ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0024121
Disease: Lung Neoplasms
Lung Neoplasms 		0.360 Biomarker group CTD_human Beclin1-induced autophagy abrogates radioresistance of lung cancer cells by suppressing osteopontin. 22481206 2012
CUI: C0024121
Disease: Lung Neoplasms
Lung Neoplasms 		0.360 Biomarker group CTD_human Varied pathways of stage IA lung adenocarcinomas discovered by integrated gene expression analysis. 21552421 2011
CUI: C0024121
Disease: Lung Neoplasms
Lung Neoplasms 		0.360 Biomarker group LHGDN Abrogation of the interaction between osteopontin and alphavbeta3 integrin reduces tumor growth of human lung cancer cells in mice. 17482311 2007
CUI: C0024121
Disease: Lung Neoplasms
Lung Neoplasms 		0.360 AlteredExpression group LHGDN An evaluation of tumor oxygenation and gene expression in patients with early stage non-small cell lung cancers. 16533775 2006
CUI: C0024121
Disease: Lung Neoplasms
Lung Neoplasms 		0.360 AlteredExpression group LHGDN Osteopontin expression and prognostic significance in non-small cell lung cancer. 16166420 2005
CUI: C0024121
Disease: Lung Neoplasms
Lung Neoplasms 		0.360 AlteredExpression group LHGDN Overexpression of osteopontin is associated with more aggressive phenotypes in human non-small cell lung cancer. 16000556 2005
CUI: C0024121
Disease: Lung Neoplasms
Lung Neoplasms 		0.360 Biomarker group BEFREE The purpose of this study was to better define the role of osteopontin (OPN) and osteonectin [also known as secreted protein acidic and rich in cysteine (SPARC)] in lung tumorigenesis by comparing the expressions of these genes in lung tumor tissue and matched normal tissue and by determining the prognostic significance of the gene expressions. 15014008 2004
CUI: C0024121
Disease: Lung Neoplasms
Lung Neoplasms 		0.360 AlteredExpression group BEFREE These findings suggest that OPN levels in lung tumors have the potential to provide clinically important predictive information on patient outcome, and that OPN may play a role in the biology of lung cancer. 8959677 1996