SPP1, secreted phosphoprotein 1, 6696

N. diseases: 824; N. variants: 13
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0025202
Disease: melanoma
melanoma
0.100 Biomarker disease BEFREE The aim of our study was to evaluate the utility of osteoprotegerin (OPG), osteopontin (OPN), epidermal growth factor (EGF) and vascular endothelial growth factor VEGF for the diagnosis and prognosis of melanoma. 30061268 2018
CUI: C0025202
Disease: melanoma
melanoma
0.100 AlteredExpression disease BEFREE Active FAK in turn accumulated in the nucleus where it led to the expression of osteopontin and other FN-type matrix in both mouse embryonic fibroblasts and human melanoma. 28348210 2017
CUI: C0025202
Disease: melanoma
melanoma
0.100 AlteredExpression disease BEFREE The major purpose of this study was to define OPN expression in primary melanomas with differing biological behaviours. 25944164 2015
CUI: C0025202
Disease: melanoma
melanoma
0.100 Biomarker disease BEFREE Evaluation of serum osteopontin level and gene polymorphism as biomarkers: analyses from the Nordic Adjuvant Interferon alpha Melanoma trial. 25832001 2015
CUI: C0025202
Disease: melanoma
melanoma
0.100 Biomarker disease BEFREE These data suggest that OPN promotes melanoma cell invasion by activating integrin αvβ3 and down-regulating CD9, a putative metastasis suppressor. 24412090 2014
CUI: C0025202
Disease: melanoma
melanoma
0.100 Biomarker disease BEFREE These data provide compelling evidence that OPN and COX-2 expressing macrophages are obligatory factors in melanoma growth. 23728342 2014
CUI: C0025202
Disease: melanoma
melanoma
0.100 Biomarker disease BEFREE OPN derived from tumor-activated macrophages modulates the tumor microenvironment and thereby regulate melanoma growth and angiogenesis. 24899149 2014
CUI: C0025202
Disease: melanoma
melanoma
0.100 Biomarker disease BEFREE Plasma osteopontin concentrations in patients with cutaneous melanoma. 23934016 2013
CUI: C0025202
Disease: melanoma
melanoma
0.100 GeneticVariation disease BEFREE Elevated levels of the oncoprotein, osteopontin (OPN), are associated with poor outcome of several types of cancers including melanoma. 22266849 2012
CUI: C0025202
Disease: melanoma
melanoma
0.100 AlteredExpression disease BEFREE To optimise predictive models for sentinal node biopsy (SNB) positivity, relapse and survival, using clinico-pathological characteristics and osteopontin gene expression in primary melanomas. 20859289 2010
CUI: C0025202
Disease: melanoma
melanoma
0.100 Biomarker disease BEFREE In this study we report that expression of GLI1 and osteopontin (OPN) increase progressively with the progression of melanoma from primary cutaneous cancer to metastatic melanoma in clinically derived specimens. 19556240 2009
CUI: C0025202
Disease: melanoma
melanoma
0.100 Biomarker disease BEFREE Expression data were obtained from 74% of primary melanomas and provided confirmatory evidence that osteopontin expression is a prognostic biomarker. 19887478 2009
CUI: C0025202
Disease: melanoma
melanoma
0.100 AlteredExpression disease BEFREE In line with this, immunoblotting showed significantly enhanced baseline and bFGF-induced OPN protein expression in melanoma cell lines which were homozygous for the -443C allele, compared with cell lines with other allelic variants. 18459127 2009
CUI: C0025202
Disease: melanoma
melanoma
0.100 AlteredExpression disease LHGDN Endothelin signaling axis activates osteopontin expression through PI3 kinase pathway in A375 melanoma cells. 18722093 2008
CUI: C0025202
Disease: melanoma
melanoma
0.100 AlteredExpression disease BEFREE Overexpression of osteopontin has been found in a variety of cancers, including breast cancer, lung cancer, colorectal cancer, stomach cancer, ovarian cancer, and melanoma. 17548669 2007
CUI: C0025202
Disease: melanoma
melanoma
0.100 Biomarker disease BEFREE CD44 surface expression and MMP-2 activity in the conditioned medium were increased to a greater extent in M21/OPN cells as compared with M21 or alpha(v)995 cells. 16631740 2006
CUI: C0025202
Disease: melanoma
melanoma
0.100 AlteredExpression disease BEFREE Diffuse strong expression of osteopontin was detected in eight samples of uveal melanomas metastatic to the liver. 16505010 2006
CUI: C0025202
Disease: melanoma
melanoma
0.100 Biomarker disease LHGDN The inverse correlation between OPN and PTEN expression was validated (P<0.02) by immunohistochemistry using melanoma tissue microarrays. 16571650 2006
CUI: C0025202
Disease: melanoma
melanoma
0.100 Biomarker disease BEFREE Our observations suggest that OPN may be acquired early in melanoma development and progression, and may enhance tumor cell growth in invasive melanoma. 15854047 2005
CUI: C0025202
Disease: melanoma
melanoma
0.100 AlteredExpression disease BEFREE In melanocytes, expression of the secreted adhesion protein OPN was up-regulated by the melanoma-inducing receptor tyrosine kinase Xmrk as well as by the fibroblast growth factor receptor, which plays a decisive role in human melanoma. 12183442 2002