Fibrosis, Liver
|
0.400 |
Biomarker
|
disease |
BEFREE |
We aimed to assess the diagnostic value of both biglycan (BGN) and osteopontin (OPN) as non-invasive markers of hepatic fibrosis in patients with chronic hepatitis B (CHB) and chronic hepatitis C (CHC).
|
30385593 |
2019 |
Fibrosis, Liver
|
0.400 |
Biomarker
|
disease |
BEFREE |
Thr-OPN peptides exacerbated liver fibrosis in OPN-deficient mice, whereas the neutralization of Thr-OPN alleviated liver fibrosis in wild-type mice.
|
30350863 |
2019 |
Fibrosis, Liver
|
0.400 |
Biomarker
|
disease |
BEFREE |
The potential anti-fibrotic activity and the effect of mesalazine on osteopontin (OPN), an extra cellular matrix (ECM) component were evaluated in TAA-induced liver fibrosis in rats.
|
29738702 |
2018 |
Fibrosis, Liver
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
GSK-3β inhibition by SB216763 treatment aggravated liver fibrosis and elevated the expression of osteopontin (OPN) in the BDL mouse model.
|
29529390 |
2018 |
Fibrosis, Liver
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Our results showed that hepatic expression of OPN was increased in patients with liver fibrosis.
|
29196165 |
2018 |
Fibrosis, Liver
|
0.400 |
Biomarker
|
disease |
BEFREE |
We conclude that HCC is associated with overexpression of both Osteopontin and Pokémon and that Osteopontin plays a significant role in liver fibrosis due to hepatitis C infection.
|
30417409 |
2018 |
Fibrosis, Liver
|
0.400 |
Biomarker
|
disease |
BEFREE |
Since OPN was identified as upstream of HMGB1, we hypothesised that OPN could participate in the pathogenesis of liver fibrosis by increasing HMGB1 to upregulate collagen-I expression.
|
26818617 |
2017 |
Fibrosis, Liver
|
0.400 |
Biomarker
|
disease |
BEFREE |
Epigallocatechin-3-Gallate Upregulates miR-221 to Inhibit Osteopontin-Dependent Hepatic Fibrosis.
|
27935974 |
2016 |
Fibrosis, Liver
|
0.400 |
Biomarker
|
disease |
BEFREE |
Liver OPN was evaluated by qRTPCR and immunohistochemistry (IHC) and correlated with liver fibrosis and serum OPN.
|
26201095 |
2015 |
Fibrosis, Liver
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Advanced liver fibrosis (S ≥ 2) was associated with increased levels of omentin and osteopontin (436.94 vs 360.09, P = 0.03 and 32.84 vs 20.29, P = 0.03) and reduced resistin concentration (1.40 vs 1.74, P = 0.047).
|
25132761 |
2014 |
Fibrosis, Liver
|
0.400 |
Biomarker
|
disease |
BEFREE |
When fed MCD diets, Ptc(+/-) mice expressed more OPN and developed worse liver fibrosis (P < 0.05) than WT mice, whereas OPN-deficient mice exhibited reduced fibrosis (P < 0.05).
|
20967826 |
2011 |
Fibrosis, Liver
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Correlations of osteopontin expression with other variables (α-SMA, TGF-β1, hepatopathologic features including granuloma formation and degree of liver fibrosis) were analyzed.
|
22171141 |
2011 |
Fibrosis, Liver
|
0.400 |
Biomarker
|
disease |
CTD_human |
Osteopontin expression in normal and fibrotic liver. altered liver healing in osteopontin-deficient mice.
|
16221502 |
2006 |