SPP1, secreted phosphoprotein 1, 6696

N. diseases: 824; N. variants: 13
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0017638
Disease: Glioma
Glioma
0.600 AlteredExpression disease BEFREE Analysis of the RNA-Seq data from The Cancer Genome Atlas database showed that the increased SPP1 mRNA expression in lower-grade glioma was significantly associated with poor survival outcomes in patients with lower-grade glioma. 31295606 2019
CUI: C0017638
Disease: Glioma
Glioma
0.600 Biomarker disease BEFREE These infiltrating macrophages secrete SPP1, which sustains glioma cell survival and stimulates angiogenesis. 31185211 2019
CUI: C0017638
Disease: Glioma
Glioma
0.600 Biomarker disease BEFREE Both tumor-derived and host-derived OPN were critical for glioma development. 30307407 2019
CUI: C0022650
Disease: Kidney Calculi
Kidney Calculi
0.600 Biomarker disease BEFREE Inhibitive Effects of Huashi Pill on Formation of Renal Stones by Modulating Urine Biochemical Indexes and Osteopontin in Renal Stone Rat Models. 31690714 2019
CUI: C0022650
Disease: Kidney Calculi
Kidney Calculi
0.600 AlteredExpression disease BEFREE Activation of liver X receptor suppresses osteopontin expression and ameliorates nephrolithiasis. 30623435 2019
CUI: C0022650
Disease: Kidney Calculi
Kidney Calculi
0.600 AlteredExpression disease BEFREE Metformin prevents nephrolithiasis formation by inhibiting the expression of OPN and MCP-1 in vitro and in vivo. 30720053 2019
CUI: C0022650
Disease: Kidney Calculi
Kidney Calculi
0.600 Biomarker disease BEFREE Here, we quantitatively investigate the role of phosphorylation in interactions with calcium oxalate monohydrate crystals (COM), using synthetic peptides corresponding to the sequence 220-235 in osteopontin, a major inhibitor of kidney stone-related COM formation. 30569197 2019
CUI: C0017638
Disease: Glioma
Glioma
0.600 Biomarker disease BEFREE OPN expression increases in correlation to the glioma malignancy from 4.5 ± 1.8% (I) to 12.3 ± 1.2% of OPN+ cells (III). 30140373 2018
CUI: C0022650
Disease: Kidney Calculi
Kidney Calculi
0.600 AlteredExpression disease BEFREE The aim of the study was assessment of four selected macromolecules level: osteopontin, calgranulin, uromodulin and bikunin in fresh morning urine sample in children with nephrolithiasis in the course of idiopathic hypercalciuria. 29353465 2018
CUI: C0022650
Disease: Kidney Calculi
Kidney Calculi
0.600 AlteredExpression disease BEFREE The purpose of this study is to evaluate the correlation between urinary OPN level and kidney stone formation and effect of nutrition on OPN level in nephrolithiasis. 30114399 2018
CUI: C0022650
Disease: Kidney Calculi
Kidney Calculi
0.600 Biomarker disease BEFREE Here, we investigated the effects of different phosphorylated states of a synthesized peptide of OPN (the ASARM peptide; acidic, serine- and aspartate-rich motif) on calcium oxalate dihydrate (COD) crystals, a major mineral phase of kidney stones. 30016645 2018
CUI: C0017638
Disease: Glioma
Glioma
0.600 AlteredExpression disease BEFREE We reveal that SPP1 is overexpressed in glioma initiating cells defined by high rhodamine 123 efflux, sphere forming capacity and stemness marker expression. 28030801 2017
CUI: C0022650
Disease: Kidney Calculi
Kidney Calculi
0.600 Biomarker disease BEFREE The results advocate possible association of osteopontin with ER stress, thus suggesting that the ER could be a new target for developing therapeutic regimes for kidney stones. 28442375 2017
CUI: C0022650
Disease: Kidney Calculi
Kidney Calculi
0.600 Biomarker disease BEFREE RT-PCR analysis and immunocytochemistry of NRK-52E cells revealed the up-regulation of inflammatory and stress biomarkers OPN and HSP-70, respectively, in response to COM toxicity; which diminished significantly in the presence of kidney stone matrix proteins. 29054323 2017
CUI: C0022650
Disease: Kidney Calculi
Kidney Calculi
0.600 Biomarker disease BEFREE To further investigate the role of Opn, we used a double-knockout strategy, which provides evidence that loss of Opn worsens the nephrocalcinosis and nephrolithiasis observed in these mice on a high-phosphate diet. 27784695 2017
CUI: C0022650
Disease: Kidney Calculi
Kidney Calculi
0.600 Biomarker disease BEFREE We previously reported the potential therapeutic role of osteopontin (OPN) and macrophages in CaOx kidney stone formation, discovered using genome-recombined mice and genome-wide analyses. 27297950 2017
CUI: C0022650
Disease: Kidney Calculi
Kidney Calculi
0.600 Biomarker disease BEFREE The Effects of Melatonin on Ethylene Glycol-induced Nephrolithiasis: Role on Osteopontin mRNA Gene Expression. 27717860 2017
CUI: C0017638
Disease: Glioma
Glioma
0.600 Biomarker disease BEFREE We have recently demonstrated the importance of osteopontin (OPN) in the acquisition/maintenance of stemness characters and tumorigenicity of glioma initiating cells. 27563812 2016
CUI: C0017638
Disease: Glioma
Glioma
0.600 Biomarker disease BEFREE These strategies allow us to define an important role of OPN in conferring cancer hallmarks, which can be further applied to assess the functional roles of other candidate genes in glioma. 27198662 2016
CUI: C0017638
Disease: Glioma
Glioma
0.600 AlteredExpression disease BEFREE Downregulation of osteopontin enhances the sensitivity of glioma U251 cells to temozolomide and cisplatin by targeting the NF-κB/Bcl‑2 pathway. 25405848 2015
CUI: C0017638
Disease: Glioma
Glioma
0.600 AlteredExpression disease BEFREE Glioma-associated microglia/macrophages display an expression profile different from M1 and M2 polarization and highly express Gpnmb and Spp1. 25658639 2015
CUI: C0017638
Disease: Glioma
Glioma
0.600 GeneticVariation disease BEFREE Polymorphism -433 C>T of the Osteopontin gene is associated with the susceptibility to develop gliomas and their prognosis in a Chinese cohort. 25277531 2014
CUI: C0017638
Disease: Glioma
Glioma
0.600 AlteredExpression disease BEFREE Thrombin-cleaved fragments of osteopontin are overexpressed in malignant glial tumors and provide a molecular niche with survival advantage. 23204518 2013
CUI: C0022650
Disease: Kidney Calculi
Kidney Calculi
0.600 AlteredExpression disease BEFREE Taken together, our findings suggest that gallotannin can contribute to nephrolithiasis prevention via direct effects on renal epithelial cells including suppression of COM binding and MCP-1 and OPN expression, along with augmenting antioxidant activity. 22466558 2012
CUI: C0022650
Disease: Kidney Calculi
Kidney Calculi
0.600 GeneticVariation disease BEFREE SPP1 polymorphisms were found to be associated with nephrolithiasis and it may be suggested that SPP1 gene polymorphism could be a useful marker for evaluation of the early genetic risk factor in childhood nephrolithiasis. 23235966 2012