Glioma
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Analysis of the RNA-Seq data from The Cancer Genome Atlas database showed that the increased SPP1 mRNA expression in lower-grade glioma was significantly associated with poor survival outcomes in patients with lower-grade glioma.
|
31295606 |
2019 |
Glioma
|
0.600 |
Biomarker
|
disease |
BEFREE |
These infiltrating macrophages secrete SPP1, which sustains glioma cell survival and stimulates angiogenesis.
|
31185211 |
2019 |
Glioma
|
0.600 |
Biomarker
|
disease |
BEFREE |
Both tumor-derived and host-derived OPN were critical for glioma development.
|
30307407 |
2019 |
Kidney Calculi
|
0.600 |
Biomarker
|
disease |
BEFREE |
Inhibitive Effects of Huashi Pill on Formation of Renal Stones by Modulating Urine Biochemical Indexes and Osteopontin in Renal Stone Rat Models.
|
31690714 |
2019 |
Kidney Calculi
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Activation of liver X receptor suppresses osteopontin expression and ameliorates nephrolithiasis.
|
30623435 |
2019 |
Kidney Calculi
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Metformin prevents nephrolithiasis formation by inhibiting the expression of OPN and MCP-1 in vitro and in vivo.
|
30720053 |
2019 |
Kidney Calculi
|
0.600 |
Biomarker
|
disease |
BEFREE |
Here, we quantitatively investigate the role of phosphorylation in interactions with calcium oxalate monohydrate crystals (COM), using synthetic peptides corresponding to the sequence 220-235 in osteopontin, a major inhibitor of kidney stone-related COM formation.
|
30569197 |
2019 |
Glioma
|
0.600 |
Biomarker
|
disease |
BEFREE |
OPN expression increases in correlation to the glioma malignancy from 4.5 ± 1.8% (I) to 12.3 ± 1.2% of OPN+ cells (III).
|
30140373 |
2018 |
Kidney Calculi
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
The aim of the study was assessment of four selected macromolecules level: osteopontin, calgranulin, uromodulin and bikunin in fresh morning urine sample in children with nephrolithiasis in the course of idiopathic hypercalciuria.
|
29353465 |
2018 |
Kidney Calculi
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
The purpose of this study is to evaluate the correlation between urinary OPN level and kidney stone formation and effect of nutrition on OPN level in nephrolithiasis.
|
30114399 |
2018 |
Kidney Calculi
|
0.600 |
Biomarker
|
disease |
BEFREE |
Here, we investigated the effects of different phosphorylated states of a synthesized peptide of OPN (the ASARM peptide; acidic, serine- and aspartate-rich motif) on calcium oxalate dihydrate (COD) crystals, a major mineral phase of kidney stones.
|
30016645 |
2018 |
Glioma
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
We reveal that SPP1 is overexpressed in glioma initiating cells defined by high rhodamine 123 efflux, sphere forming capacity and stemness marker expression.
|
28030801 |
2017 |
Kidney Calculi
|
0.600 |
Biomarker
|
disease |
BEFREE |
The results advocate possible association of osteopontin with ER stress, thus suggesting that the ER could be a new target for developing therapeutic regimes for kidney stones.
|
28442375 |
2017 |
Kidney Calculi
|
0.600 |
Biomarker
|
disease |
BEFREE |
RT-PCR analysis and immunocytochemistry of NRK-52E cells revealed the up-regulation of inflammatory and stress biomarkers OPN and HSP-70, respectively, in response to COM toxicity; which diminished significantly in the presence of kidney stone matrix proteins.
|
29054323 |
2017 |
Kidney Calculi
|
0.600 |
Biomarker
|
disease |
BEFREE |
To further investigate the role of Opn, we used a double-knockout strategy, which provides evidence that loss of Opn worsens the nephrocalcinosis and nephrolithiasis observed in these mice on a high-phosphate diet.
|
27784695 |
2017 |
Kidney Calculi
|
0.600 |
Biomarker
|
disease |
BEFREE |
We previously reported the potential therapeutic role of osteopontin (OPN) and macrophages in CaOx kidney stone formation, discovered using genome-recombined mice and genome-wide analyses.
|
27297950 |
2017 |
Kidney Calculi
|
0.600 |
Biomarker
|
disease |
BEFREE |
The Effects of Melatonin on Ethylene Glycol-induced Nephrolithiasis: Role on Osteopontin mRNA Gene Expression.
|
27717860 |
2017 |
Glioma
|
0.600 |
Biomarker
|
disease |
BEFREE |
We have recently demonstrated the importance of osteopontin (OPN) in the acquisition/maintenance of stemness characters and tumorigenicity of glioma initiating cells.
|
27563812 |
2016 |
Glioma
|
0.600 |
Biomarker
|
disease |
BEFREE |
These strategies allow us to define an important role of OPN in conferring cancer hallmarks, which can be further applied to assess the functional roles of other candidate genes in glioma.
|
27198662 |
2016 |
Glioma
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Downregulation of osteopontin enhances the sensitivity of glioma U251 cells to temozolomide and cisplatin by targeting the NF-κB/Bcl‑2 pathway.
|
25405848 |
2015 |
Glioma
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Glioma-associated microglia/macrophages display an expression profile different from M1 and M2 polarization and highly express Gpnmb and Spp1.
|
25658639 |
2015 |
Glioma
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Polymorphism -433 C>T of the Osteopontin gene is associated with the susceptibility to develop gliomas and their prognosis in a Chinese cohort.
|
25277531 |
2014 |
Glioma
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Thrombin-cleaved fragments of osteopontin are overexpressed in malignant glial tumors and provide a molecular niche with survival advantage.
|
23204518 |
2013 |
Kidney Calculi
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Taken together, our findings suggest that gallotannin can contribute to nephrolithiasis prevention via direct effects on renal epithelial cells including suppression of COM binding and MCP-1 and OPN expression, along with augmenting antioxidant activity.
|
22466558 |
2012 |
Kidney Calculi
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
SPP1 polymorphisms were found to be associated with nephrolithiasis and it may be suggested that SPP1 gene polymorphism could be a useful marker for evaluation of the early genetic risk factor in childhood nephrolithiasis.
|
23235966 |
2012 |