Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0017638
Disease: Glioma
Glioma
0.600 Biomarker disease BEFREE Specific inhibition of OPN in both murine and human glioma tumors prolonged mice survival. 25961929 2016
CUI: C0017638
Disease: Glioma
Glioma
0.600 AlteredExpression disease BEFREE Glioma-associated microglia/macrophages display an expression profile different from M1 and M2 polarization and highly express Gpnmb and Spp1. 25658639 2016
CUI: C0017638
Disease: Glioma
Glioma
0.600 GeneticVariation disease BEFREE Polymorphism -433 C>T of the Osteopontin gene is associated with the susceptibility to develop gliomas and their prognosis in a Chinese cohort. 25277531 2015
CUI: C0017638
Disease: Glioma
Glioma
0.600 AlteredExpression disease BEFREE Downregulation of osteopontin enhances the sensitivity of glioma U251 cells to temozolomide and cisplatin by targeting the NF-κB/Bcl‑2 pathway. 25405848 2015
CUI: C0017638
Disease: Glioma
Glioma
0.600 Biomarker disease BEFREE In addition, a subnetwork was constructed among SPP1 (secreted phosphoprotein 1), SDC1 (syndecan 1) and CD44 based on protein-protein interactions, and these genes were predicted to be involved in glioma cell invasion. 22906261 2013
CUI: C0017638
Disease: Glioma
Glioma
0.600 AlteredExpression disease BEFREE Thrombin-cleaved fragments of osteopontin are overexpressed in malignant glial tumors and provide a molecular niche with survival advantage. 23204518 2013
CUI: C0017638
Disease: Glioma
Glioma
0.600 AlteredExpression disease BEFREE Overexpression of osteopontin induces angiogenesis of endothelial progenitor cells via the avβ3/PI3K/AKT/eNOS/NO signaling pathway in glioma cells. 21616556 2011
CUI: C0017638
Disease: Glioma
Glioma
0.600 GeneticVariation disease BEFREE SPP1 promoter polymorphisms and glioma risk in a Chinese Han population. 20505679 2010
CUI: C0017638
Disease: Glioma
Glioma
0.600 AlteredExpression disease BEFREE Expression pattern of osteopontin splice variants and its functions on cell apoptosis and invasion in glioma cells. 20511184 2010
CUI: C0017638
Disease: Glioma
Glioma
0.600 Biomarker disease BEFREE This is the first demonstration that OPN inhibition blocks glioma tumor growth, making this invasion-related protein an attractive target for glioma therapy. 19609945 2010
CUI: C0017638
Disease: Glioma
Glioma
0.600 AlteredExpression disease BEFREE We propose that local produced, high level OPN expression limits the malignant character of glioma cells and that the downstream mechanisms involved represent pathways that may have therapeutic value in the treatment of human CNS malignancy. 17928956 2008
CUI: C0017638
Disease: Glioma
Glioma
0.600 Biomarker disease RGD Based on these findings, we conclude that OPN overexpression in ENU-induced gliomas occurs within a specific subset of intratumoral glial fibrillary acidic protein-positive cells and becomes evident at the stage of tumor progression. 16651633 2006
CUI: C0017638
Disease: Glioma
Glioma
0.600 Biomarker disease CTD_human By contrast, no OPN immunostaining was seen in normal brain or in brains removed from ENU-exposed rats before the development of glioma. 16651633 2006
CUI: C0017638
Disease: Glioma
Glioma
0.600 Biomarker disease CTD_human In conjunction with this, we confirmed that both normal neurosphere cells and ENU-im-mortalized subventricular zone/striatal cells produced negligible amounts of OPN compared to the established rat glioma cell line C6. 16651633 2006
CUI: C0017638
Disease: Glioma
Glioma
0.600 Biomarker disease CTD_human Based on these findings, we conclude that OPN overexpression in ENU-induced gliomas occurs within a specific subset of intratumoral glial fibrillary acidic protein-positive cells and becomes evident at the stage of tumor progression. 16651633 2006
CUI: C0017638
Disease: Glioma
Glioma
0.600 Biomarker disease CTD_human Osteopontin expression in intratumoral astrocytes marks tumor progression in gliomas induced by prenatal exposure to N-ethyl-N-nitrosourea. 16651633 2006
CUI: C0017638
Disease: Glioma
Glioma
0.600 Biomarker disease RGD Osteopontin expression in intratumoral astrocytes marks tumor progression in gliomas induced by prenatal exposure to N-ethyl-N-nitrosourea. 16651633 2006
CUI: C0017638
Disease: Glioma
Glioma
0.600 Biomarker disease RGD Our analysis identified osteopontin (OPN) as the most up-regulated gene in glioma. 16651633 2006
CUI: C0017638
Disease: Glioma
Glioma
0.600 Biomarker disease RGD In conjunction with this, we confirmed that both normal neurosphere cells and ENU-im-mortalized subventricular zone/striatal cells produced negligible amounts of OPN compared to the established rat glioma cell line C6. 16651633 2006
CUI: C0017638
Disease: Glioma
Glioma
0.600 Biomarker disease RGD By contrast, no OPN immunostaining was seen in normal brain or in brains removed from ENU-exposed rats before the development of glioma. 16651633 2006
CUI: C0017638
Disease: Glioma
Glioma
0.600 Biomarker disease CTD_human Our analysis identified osteopontin (OPN) as the most up-regulated gene in glioma. 16651633 2006
CUI: C0017638
Disease: Glioma
Glioma
0.600 Biomarker disease BEFREE Hyaluronic acid induces osteopontin via the phosphatidylinositol 3-kinase/Akt pathway to enhance the motility of human glioma cells. 15705860 2005
CUI: C0017638
Disease: Glioma
Glioma
0.600 Biomarker disease BEFREE Elucidation of regulatory mechanisms for OPN induction in glioma cells should facilitate rational design of novel therapeutics for human malignant gliomas. 9615723 1998
CUI: C0017638
Disease: Glioma
Glioma
0.600 AlteredExpression disease BEFREE Expression of osteopontin in human glioma. Its correlation with the malignancy. 7837791 1995
CUI: C0555198
Disease: Malignant Glioma
Malignant Glioma
0.510 AlteredExpression disease BEFREE Osteopontin and splice variant expression level in human malignant glioma: radiobiologic effects and prognosis after radiotherapy. 23891093 2014