Malignant tumor of colon
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Thus, the present study suggests that activation of SRC is responsible for doxorubicin resistance in colon cancer.
|
29581735 |
2018 |
Malignant tumor of colon
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Dual inhibition of MET and SRC kinase activity as a combined targeting strategy for colon cancer.
|
28810597 |
2017 |
Malignant tumor of colon
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Cytoplasmic Localization of RUNX3 via Histone Deacetylase-Mediated SRC Expression in Oxidative-Stressed Colon Cancer Cells.
|
27990641 |
2017 |
Malignant tumor of colon
|
0.400 |
Biomarker
|
disease |
BEFREE |
Importantly, hyperactivation of SRC/EGFR signaling triggered by loss of PTPRO leads to high resistance of colon cancer to EGFR inhibitors.
|
25301722 |
2014 |
Malignant tumor of colon
|
0.400 |
Biomarker
|
disease |
BEFREE |
These results implicate alternative targeting of MET or SRC as rational strategies for reversing cetuximab resistance in colon cancer.
|
24714091 |
2014 |
Malignant tumor of colon
|
0.400 |
Biomarker
|
disease |
BEFREE |
However, although Src protein is increased in colon cancer as early as the adenomatous polyp stage, a role for Src in carcinogenesis has not been established.
|
18351644 |
2008 |
Malignant tumor of colon
|
0.400 |
Biomarker
|
disease |
CTD_human |
Nicotine promoted colon cancer growth via epidermal growth factor receptor, c-Src, and 5-lipoxygenase-mediated signal pathway.
|
14569062 |
2004 |
Malignant tumor of colon
|
0.400 |
Biomarker
|
disease |
BEFREE |
Insulin-like growth factor 1 receptor activates c-SRC and modifies transformation and motility of colon cancer in vitro.
|
12820418 |
2003 |
Malignant tumor of colon
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
However, two subsequent studies have failed to confirm the occurrence of SRC 531 mutation in colorectal cancers from North-European and Asiatic patients, raising the hypothesis that the genetic activation of src in colon cancer might be restricted to patients belonging to specific ethnic groups.
|
11161376 |
2001 |
Malignant tumor of colon
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Thus, mutation at Gln-531 of src gene does not seem to be involved in the development of colon cancer in Chinese ethnicity.
|
10704743 |
2000 |
Malignant tumor of colon
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Recently, an activating mutation of the SRC gene has been implicated in about one-tenth of advanced colon cancers.
|
10804287 |
2000 |
Malignant tumor of colon
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
These results provide, for the first time, genetic evidence that activating SRC mutations may have a role in the malignant progression of human colon cancer.
|
9988270 |
1999 |
Malignant tumor of colon
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
However, recently truncating mutations at codon 531 of the c-src gene were reported in 12% of the advanced colon cancers, and it was also demonstrated that this change was activating, transforming, tumorigenic, and metastasis promoting.
|
10485460 |
1999 |
Malignant tumor of colon
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Abundance of calpactin I in such cells is consistent with the possibility that activation of the pp60c-src tyrosine kinase contributes to the origin of human colon cancers.
|
1280033 |
1992 |