Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon
0.400 AlteredExpression disease BEFREE Thus, the present study suggests that activation of SRC is responsible for doxorubicin resistance in colon cancer. 29581735 2018
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon
0.400 AlteredExpression disease BEFREE Dual inhibition of MET and SRC kinase activity as a combined targeting strategy for colon cancer. 28810597 2017
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon
0.400 AlteredExpression disease BEFREE Cytoplasmic Localization of RUNX3 via Histone Deacetylase-Mediated SRC Expression in Oxidative-Stressed Colon Cancer Cells. 27990641 2017
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon
0.400 Biomarker disease BEFREE Importantly, hyperactivation of SRC/EGFR signaling triggered by loss of PTPRO leads to high resistance of colon cancer to EGFR inhibitors. 25301722 2014
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon
0.400 Biomarker disease BEFREE These results implicate alternative targeting of MET or SRC as rational strategies for reversing cetuximab resistance in colon cancer. 24714091 2014
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon
0.400 Biomarker disease BEFREE However, although Src protein is increased in colon cancer as early as the adenomatous polyp stage, a role for Src in carcinogenesis has not been established. 18351644 2008
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon
0.400 Biomarker disease CTD_human Nicotine promoted colon cancer growth via epidermal growth factor receptor, c-Src, and 5-lipoxygenase-mediated signal pathway. 14569062 2004
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon
0.400 Biomarker disease BEFREE Insulin-like growth factor 1 receptor activates c-SRC and modifies transformation and motility of colon cancer in vitro. 12820418 2003
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon
0.400 GeneticVariation disease BEFREE However, two subsequent studies have failed to confirm the occurrence of SRC 531 mutation in colorectal cancers from North-European and Asiatic patients, raising the hypothesis that the genetic activation of src in colon cancer might be restricted to patients belonging to specific ethnic groups. 11161376 2001
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon
0.400 GeneticVariation disease BEFREE Thus, mutation at Gln-531 of src gene does not seem to be involved in the development of colon cancer in Chinese ethnicity. 10704743 2000
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon
0.400 GeneticVariation disease BEFREE Recently, an activating mutation of the SRC gene has been implicated in about one-tenth of advanced colon cancers. 10804287 2000
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon
0.400 GeneticVariation disease BEFREE These results provide, for the first time, genetic evidence that activating SRC mutations may have a role in the malignant progression of human colon cancer. 9988270 1999
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon
0.400 GeneticVariation disease BEFREE However, recently truncating mutations at codon 531 of the c-src gene were reported in 12% of the advanced colon cancers, and it was also demonstrated that this change was activating, transforming, tumorigenic, and metastasis promoting. 10485460 1999
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon
0.400 AlteredExpression disease BEFREE Abundance of calpactin I in such cells is consistent with the possibility that activation of the pp60c-src tyrosine kinase contributes to the origin of human colon cancers. 1280033 1992