Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0278838
Disease: Prostate cancer recurrent
Prostate cancer recurrent
0.010 Biomarker disease BEFREE An elevated tumor tissue androgen level, which reactivates androgen receptor in recurrent prostate cancer, arises from the intratumor synthesis of 5α-dihydrotestosterone through use of the precursor steroid dehydroepiandrosterone (DHEA) and is fueled by the steroidogenic enzymes 3β-hydroxysteroid dehydrogenase (3β-HSD1), aldoketoreductase (AKR1C3), and steroid 5-alpha reductase, type 1 (SRD5A1) present in cancer tissue. 23579488 2013