Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Metastasis from malignant tumor of prostate
0.020 GeneticVariation disease BEFREE We studied the polymorphisms rs518673 and rs166050 in SRD5A1, and rs12470143, rs523349, rs676033 and rs2208532 in SRD5A2 as well as the time to CRPC progression and overall survival in 104 patients with metastatic prostate cancer that had undergone primary ADT. 26169017 2015
Metastasis from malignant tumor of prostate
0.020 AlteredExpression disease BEFREE Our data showed that 5α-reductase SRD5A1 and SRD5A3 isoenzymes that are responsible for the conversion of testosterone to DHT, are highly expressed in metastatic prostate cancer compared to benign and localized prostate cancer. 22415461 2013