BRCA1, BRCA1 DNA repair associated, 672

N. diseases: 747; N. variants: 2600
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0011570
Disease: Mental Depression
Mental Depression
0.350 Biomarker disease BEFREE First, we performed a quantitative investigation using FACT-B (Chinese version) and Irritability, Depression and Anxiety scale (IDA) to assess the QOL and PS in breast cancer patients who received BRCA1/2 genetic testing. 27428375 2016
CUI: C0011570
Disease: Mental Depression
Mental Depression
0.350 Biomarker disease PSYGENET On hierarchical regression analysis, in women with a positive BRCA1/2 result (vs NU or UV), a lower perceived probability of cancer genetic predisposition than objective estimates at T1 predicted lower levels of anxiety at T2 (β=-0.28; P<0.01), whereas in women receiving a UV result (vs NU or positive BRCA1/2), a lower perceived probability of cancer genetic predisposition than objective estimates at T1 predicted higher levels of anxiety (β=0.20; P<0.01), depression (β=0.19; P<0.05) and intrusion (β=0.18; P<0.05) at T2. 23462725 2013
CUI: C0011570
Disease: Mental Depression
Mental Depression
0.350 GeneticVariation disease BEFREE On hierarchical regression analysis, in women with a positive BRCA1/2 result (vs NU or UV), a lower perceived probability of cancer genetic predisposition than objective estimates at T1 predicted lower levels of anxiety at T2 (β=-0.28; P<0.01), whereas in women receiving a UV result (vs NU or positive BRCA1/2), a lower perceived probability of cancer genetic predisposition than objective estimates at T1 predicted higher levels of anxiety (β=0.20; P<0.01), depression (β=0.19; P<0.05) and intrusion (β=0.18; P<0.05) at T2. 23462725 2013
CUI: C0011570
Disease: Mental Depression
Mental Depression
0.350 Biomarker disease PSYGENET Two hundred and nine women with uninformative BRCA1/2 test results completed questionnaires at pretesting and 1-, 6-, and 12-month post-disclosure, including measures of anxiety and depression, cancer-specific and genetic testing distress. 19214961 2009
CUI: C0011570
Disease: Mental Depression
Mental Depression
0.350 Biomarker disease BEFREE To predict which women might suffer from abnormally high levels of anxiety and depression after receiving a positive genetic BRCA1 test result, series of pregenetic testing and postgenetic testing psychological measurements were performed. 19405874 2009
CUI: C0011570
Disease: Mental Depression
Mental Depression
0.350 Biomarker disease PSYGENET To predict which women might suffer from abnormally high levels of anxiety and depression after receiving a positive genetic BRCA1 test result, series of pregenetic testing and postgenetic testing psychological measurements were performed. 19405874 2009
CUI: C0011570
Disease: Mental Depression
Mental Depression
0.350 Biomarker disease PSYGENET Compared to mutation carriers for BRCA1, the level of anxiety and depression was significantly higher in the FBOC group with absence of demonstrated mutation. 15951962 2005
CUI: C0011570
Disease: Mental Depression
Mental Depression
0.350 AlteredExpression disease BEFREE Compared to mutation carriers for BRCA1, the level of anxiety and depression was significantly higher in the FBOC group with absence of demonstrated mutation. 15951962 2005
CUI: C0011570
Disease: Mental Depression
Mental Depression
0.350 GeneticVariation disease BEFREE In BRCA1/2-linked families, persons with high levels of cancer-related stress who decline genetic testing may be at risk for depression. 9586874 1998
CUI: C0011570
Disease: Mental Depression
Mental Depression
0.350 Biomarker disease PSYGENET In BRCA1/2-linked families, persons with high levels of cancer-related stress who decline genetic testing may be at risk for depression. 9586874 1998