BREAST CANCER, FAMILIAL, SUSCEPTIBILITY TO, 1
|
0.300 |
Biomarker
|
phenotype |
CLINGEN |
Targeting the DNA repair defect in BRCA mutant cells as a therapeutic strategy.
|
15829967 |
2005 |
BREAST CANCER, FAMILIAL, SUSCEPTIBILITY TO, 1
|
0.300 |
Biomarker
|
phenotype |
CLINGEN |
Homology-directed dna repair, mitomycin-c resistance, and chromosome stability is restored with correction of a Brca1 mutation.
|
11406561 |
2001 |
BREAST CANCER, FAMILIAL, SUSCEPTIBILITY TO, 1
|
0.300 |
Biomarker
|
phenotype |
CLINGEN |
Centrosome amplification and a defective G2-M cell cycle checkpoint induce genetic instability in BRCA1 exon 11 isoform-deficient cells.
|
10198641 |
1999 |
BREAST CANCER, FAMILIAL, SUSCEPTIBILITY TO, 1
|
0.300 |
Biomarker
|
phenotype |
CLINGEN |
Brca1 controls homology-directed DNA repair.
|
10549283 |
1999 |
BREAST CANCER, FAMILIAL, SUSCEPTIBILITY TO, 1
|
0.300 |
Biomarker
|
phenotype |
CLINGEN |
Gamma-rays-induced death of human cells carrying mutations of BRCA1 or BRCA2.
|
10602489 |
1999 |
BREAST CANCER, FAMILIAL, SUSCEPTIBILITY TO, 1
|
0.300 |
Biomarker
|
phenotype |
CLINGEN |
Stable interaction between the products of the BRCA1 and BRCA2 tumor suppressor genes in mitotic and meiotic cells.
|
9774970 |
1998 |
BREAST CANCER, FAMILIAL, SUSCEPTIBILITY TO, 1
|
0.300 |
Biomarker
|
phenotype |
CLINGEN |
Growth retardation and tumour inhibition by BRCA1.
|
8589721 |
1996 |
BREAST CANCER, FAMILIAL, SUSCEPTIBILITY TO, 1
|
0.300 |
Biomarker
|
phenotype |
CLINGEN |
Decreased expression of BRCA1 accelerates growth and is often present during sporadic breast cancer progression.
|
7795653 |
1995 |
BREAST CANCER, FAMILIAL, SUSCEPTIBILITY TO, 1
|
0.300 |
Biomarker
|
phenotype |
CLINGEN |
High allele loss rates at 17q12-q21 in breast and ovarian tumors from BRCAl-linked families. The Breast Cancer Linkage Consortium.
|
7669740 |
1995 |
BREAST CANCER, FAMILIAL, SUSCEPTIBILITY TO, 1
|
0.300 |
Biomarker
|
phenotype |
CLINGEN |
A strong candidate for the breast and ovarian cancer susceptibility gene BRCA1.
|
7545954 |
1994 |