Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Diabetes Mellitus, Non-Insulin-Dependent
0.400 PosttranslationalModification disease BEFREE Critical evaluation of the DNA-methylation markers ABCG1 and SREBF1 for Type 2 diabetes stratification. 31169416 2019
Diabetes Mellitus, Non-Insulin-Dependent
0.400 GeneticVariation disease BEFREE <b>Results</b>: Both SREBPs mRNA expression were significantly higher in patients with CAD and diabetes (p<0.001) and were identified as independent cardiovascular risk factor for coronary artery disease in patients with type-2 diabetes (SREBP-1: OR 1.7, 95%CI 1.1-2.5, p=0.02; SREBP-2: OR 1.6, 95%CI 1.2-3, p=0.02) and were independently associated with the presence of multivessel CAD, left main and anterior descending artery stenosis, and higher total and LDL cholesterol levels, and lower HDL cholesterol levels, in patients with CAD and diabetes. 28367087 2017
Diabetes Mellitus, Non-Insulin-Dependent
0.400 GeneticVariation disease BEFREE DNA methylation of cg18181703 (SOCS3), cg11024682 (SREBF1), and cg19693031 (TXNIP) was not associated with future T2D risk in subjects from the Botnia prospective study. 27148772 2016
Diabetes Mellitus, Non-Insulin-Dependent
0.400 GeneticVariation disease BEFREE We replicated in the Qatari population seven CpG associations with BMI (SOCS3, p value = 3.99 × 10(-6); SREBF1, p value = 4.33 × 10(-5); SBNO2, p value = 5.87 × 10(-5); CPT1A, p value = 7.99 × 10(-5); PRR5L, p value = 1.85 × 10(-4); cg03078551, intergenic region on chromosome 17; p value = 1.00 × 10(-3); LY6G6E, p value = 1.10 × 10(-3)) and one with T2D (TXNIP, p value = 2.46 × 10(-5)). 26823690 2016
Diabetes Mellitus, Non-Insulin-Dependent
0.400 GeneticVariation disease BEFREE Methylation markers at five loci were associated with future type 2 diabetes incidence; the relative risk per 1% increase in methylation was 1·09 (95% CI 1·07-1·11; p=1·3 × 10(-17)) for ABCG1, 0·94 (0·92-0·95; p=4·2 × 10(-11)) for PHOSPHO1, 0·94 (0·92-0·96; p=1·4 × 10(-9)) for SOCS3, 1·07 (1·04-1·09; p=2·1 × 10(-10)) for SREBF1, and 0·92 (0·90-0·94; p=1·2 × 10(-17)) for TXNIP. 26095709 2015
Diabetes Mellitus, Non-Insulin-Dependent
0.400 Biomarker disease BEFREE Furthermore, our research pinpoints the role of several new T2D-associated genes (such as Srebf1 and Ppargc1) in the human population. 25758573 2014
Diabetes Mellitus, Non-Insulin-Dependent
0.400 GeneticVariation disease BEFREE Obesity and diabetes have been established as known risk factors of EC, while SREBF-1 gene polymorphisms have also been found to be associated with obesity and type II diabetes. 24614076 2014
Diabetes Mellitus, Non-Insulin-Dependent
0.400 GeneticVariation disease GWASDB Large-scale gene-centric meta-analysis across 39 studies identifies type 2 diabetes loci. 22325160 2012
Diabetes Mellitus, Non-Insulin-Dependent
0.400 GeneticVariation disease BEFREE In silico follow-up analysis of putative association signals found in independent genome-wide association studies (including 8,130 cases and 38,987 controls) performed by the DIAGRAM consortium identified a T2D locus at genome-wide significance (GATAD2A/CILP2/PBX4; p = 5.7 × 10(-9)) and two loci exceeding study-wide significance (SREBF1, and TH/INS; p < 2.4 × 10(-6)). 22325160 2012
Diabetes Mellitus, Non-Insulin-Dependent
0.400 Biomarker disease RGD Role of atypical protein kinase C in activation of sterol regulatory element binding protein-1c and nuclear factor kappa B (NFkappaB) in liver of rodents used as a model of diabetes, and relationships to hyperlipidaemia and insulin resistance. 19357831 2009
Diabetes Mellitus, Non-Insulin-Dependent
0.400 GeneticVariation disease BEFREE We examined the presence of the Arg585Gln polymorphism in SREBF-1 in 217 consecutive unrelated Africans [73 patients with KPD, 80 with classical type 2 diabetes (T2D) and 64 nondiabetic subjects]. 19062325 2009
Diabetes Mellitus, Non-Insulin-Dependent
0.400 GeneticVariation disease BEFREE We associate sequence variation in SREBF1 with a modestly increased predisposition to type 2 diabetes. 18192539 2008
Diabetes Mellitus, Non-Insulin-Dependent
0.400 GeneticVariation disease BEFREE We aimed to confirm associations of the SREBF-1 gene with T2DM in an Austrian population and to study possible associations with diabetes-related quantitative traits. 17160088 2007
Diabetes Mellitus, Non-Insulin-Dependent
0.400 GeneticVariation disease BEFREE The G-allele carriers of the SREBF-1 gene C-G polymorphism in exon 18c and coding for glycine at the protein level (G952G) have shown to associate more frequently with obesity and type 2 diabetes than the C-allele carriers. 16005884 2006
Diabetes Mellitus, Non-Insulin-Dependent
0.400 AlteredExpression disease BEFREE A rare missense mutation in a type 2 diabetes patient decreases the transcriptional activity of human sterol regulatory element binding protein-1. 16429400 2006
Diabetes Mellitus, Non-Insulin-Dependent
0.400 Biomarker disease BEFREE The sterol regulatory element-binding protein gene (SREBF)-1 is a good candidate gene for obesity and obesity-related metabolic traits such as type 2 diabetes and dyslipidemia. 15277400 2004
Diabetes Mellitus, Non-Insulin-Dependent
0.400 GeneticVariation disease BEFREE Human obesity and type 2 diabetes are associated with alterations in SREBP1 isoform expression that are reproduced ex vivo by tumor necrosis factor-alpha. 11916923 2002