Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0015695
Disease: Fatty Liver
Fatty Liver
0.400 Biomarker disease BEFREE Our study unveils an H19/PTBP1/sterol regulatory element-binding protein 1 feedforward amplifying signaling pathway to exacerbate the development of fatty liver.(Hepatology 2018;67:1768-1783). 29140550 2018
CUI: C0015695
Disease: Fatty Liver
Fatty Liver
0.400 AlteredExpression disease BEFREE Loss of Pgrmc1 increased mature SREBP-1 protein level, suggesting that induction of hepatic steatosis in Pgrmc1 KO mice might be triggered by de novo lipogenesis. 30356113 2018
CUI: C0015695
Disease: Fatty Liver
Fatty Liver
0.400 Biomarker disease BEFREE FK866 significantly promoted liver steatosis in the mice fed with HFD and hepatic lipid accumulation in vitro, accompanied by the increases of the expressions of lipogenic genes such as sterol regulatory element-binding protein 1 (SREBP1) and fatty acid synthase (FASN). 28449683 2017
CUI: C0015695
Disease: Fatty Liver
Fatty Liver
0.400 Biomarker disease BEFREE The improvement of hepatic steatosis observed in DIO-treated mice was associated with a decrease in the hepatic content of SREBP-1, a transcription factor involved in de novo lipogenesis. 28557705 2017
CUI: C0015695
Disease: Fatty Liver
Fatty Liver
0.400 Biomarker disease BEFREE Downregulation of miR-192 causes hepatic steatosis and lipid accumulation by inducing SREBF1: Novel mechanism for bisphenol A-triggered non-alcoholic fatty liver disease. 28483554 2017
CUI: C0015695
Disease: Fatty Liver
Fatty Liver
0.400 AlteredExpression disease BEFREE Eugenol ameliorates hepatic steatosis and fibrosis by down-regulating SREBP1 gene expression via AMPK-mTOR-p70S6K signaling pathway. 25087956 2014
CUI: C0015695
Disease: Fatty Liver
Fatty Liver
0.400 Biomarker disease CTD_human A simple transcriptomic signature able to predict drug-induced hepatic steatosis. 24469900 2014
CUI: C0015695
Disease: Fatty Liver
Fatty Liver
0.400 Biomarker disease BEFREE Using miR-33(-/-)Srebf1(+/-) mice, we demonstrate that SREBP-1 is a target of miR-33 and that the mechanisms leading to obesity and liver steatosis in miR-33(-/-) mice involve enhanced expression of SREBP-1. 24300912 2013
CUI: C0015695
Disease: Fatty Liver
Fatty Liver
0.400 Biomarker disease BEFREE The present study investigated the role of the adenosine monophosphate-activated protein kinase (AMPK)-sterol regulatory element-binding protein-1 (SREBP-1) pathway in the OA-induced fatty liver. 21757781 2011
CUI: C0015695
Disease: Fatty Liver
Fatty Liver
0.400 Biomarker disease BEFREE Gentiana manshurica Kitagawa reverses acute alcohol-induced liver steatosis through blocking sterol regulatory element-binding protein-1 maturation. 21105651 2010
CUI: C0015695
Disease: Fatty Liver
Fatty Liver
0.400 Biomarker disease BEFREE They also show that the SREBP1-mediated induction of hepatic steatosis in ob/ob mice requires Gpat1. 20200319 2010
CUI: C0015695
Disease: Fatty Liver
Fatty Liver
0.400 AlteredExpression disease LHGDN SREBP-1c, regulated by the insulin and AMPK signaling pathways, plays a role in nonalcoholic fatty liver disease. 18360697 2008
CUI: C0015695
Disease: Fatty Liver
Fatty Liver
0.400 AlteredExpression disease BEFREE Furthermore, overexpression of PPARdelta by intravenous infection with the PPARdelta adenovirus induced the expression of Insig-1, suppressed SREBP-1 activation, and, consequently, ameliorated hepatic steatosis in obese db/db mice. 18627005 2008
CUI: C0015695
Disease: Fatty Liver
Fatty Liver
0.400 AlteredExpression disease BEFREE Hepatitis B virus X protein induces hepatic steatosis via transcriptional activation of SREBP1 and PPARgamma. 17484888 2007
CUI: C0015695
Disease: Fatty Liver
Fatty Liver
0.400 AlteredExpression disease LHGDN A new transgenic rat model of hepatic steatosis and the metabolic syndrome. 15809359 2005
CUI: C0015695
Disease: Fatty Liver
Fatty Liver
0.400 Biomarker disease BEFREE Constitutively active SREBP-1-overexpressing mice had fatty livers without hepatomegaly, hypoglycemia, or hypertriglyceridemia. 14633850 2003