Malignant neoplasm of lung
|
0.800 |
AlteredExpression
|
disease |
BEFREE |
Hsa_circ_0046264 and BRCA2 were down-regulated in lung cancer tissues while miR-1245 was up-regulated.
|
29891014 |
2018 |
Malignant neoplasm of lung
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
The variants in TP53, BRCA1, and BRCA2 are likely to have contributed to the early onset lung cancer in the respective patients (3/21 or 14%).
|
30032850 |
2018 |
Malignant neoplasm of lung
|
0.800 |
AlteredExpression
|
disease |
BEFREE |
Thus, this study identifies the importance of TDP1 as a novel determinant of response to CNDAC across various cancer types (especially non-small cell lung cancers), and demonstrates the differential involvement of BRCA2, PARP1, and TDP1 in the cellular responses to CNDAC, AraC, and CPT.<i></i>.
|
28802254 |
2017 |
Malignant neoplasm of lung
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
We selected eight genes, ATM serine/threonine kinase gene (ATM), BRCA2, DNA repair associated gene (BRCA2), checkpoint kinase 2 gene (CHEK2), EGFR, parkin RBR E3 ubiquitin protein ligase gene (PARK2), telomerase reverse transcriptase gene (TERT), tumor protein p53 gene (TP53), and Yes associated protein 1 gene (YAP1), on the basis of prior anecdotal association with lung cancer or genome-wide association studies.
|
28843361 |
2017 |
Malignant neoplasm of lung
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
Previous studies have shown that two rare variants, rs11571833 in BRCA2 and rs17879961 in CHEK2 were associated with lung cancer.
|
27632928 |
2016 |
Malignant neoplasm of lung
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
Although BRCA2 is important in DNA repair, few data are available on the association between BRCA2 polymorphisms and lung cancer in women.
|
26979245 |
2016 |
Malignant neoplasm of lung
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
We did not identify increased frequencies of oesophageal, pancreatic or lung cancer in families with just BRCA2 c.9976A>T using person-years at risk analysis.
|
26041759 |
2015 |
Malignant neoplasm of lung
|
0.800 |
Biomarker
|
disease |
CTD_human |
We identified large-effect genome-wide associations for squamous lung cancer with the rare variants BRCA2 p.Lys3326X (rs11571833, odds ratio (OR) = 2.47, P = 4.74 × 10(-20)) and CHEK2 p.Ile157Thr (rs17879961, OR = 0.38, P = 1.27 × 10(-13)).
|
24880342 |
2014 |
Malignant neoplasm of lung
|
0.800 |
Biomarker
|
disease |
BEFREE |
Importantly, perturbation of the ATR-RASSF1A-LATS1 signalling axis leads to genomic defects associated with loss of BRCA2 function and contributes to genomic instability and 'BRCA-ness' in lung cancers.
|
25218637 |
2014 |
Malignant neoplasm of lung
|
0.800 |
GeneticVariation
|
disease |
GWASDB |
We identified large-effect genome-wide associations for squamous lung cancer with the rare variants BRCA2 p.Lys3326X (rs11571833, odds ratio (OR) = 2.47, P = 4.74 × 10(-20)) and CHEK2 p.Ile157Thr (rs17879961, OR = 0.38, P = 1.27 × 10(-13)).
|
24880342 |
2014 |
Malignant neoplasm of lung
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
We identified large-effect genome-wide associations for squamous lung cancer with the rare variants BRCA2 p.Lys3326X (rs11571833, odds ratio (OR) = 2.47, P = 4.74 × 10(-20)) and CHEK2 rs17879961" genes_norm="11200;8626">p.Ile157Thr (rs17879961, OR = 0.38, P = 1.27 × 10(-13)).
|
24880342 |
2014 |
Malignant neoplasm of lung
|
0.800 |
Biomarker
|
disease |
BEFREE |
Antisense-mediated reduction of IDO, alone and (in a synthetic lethal approach) in combination with antisense to the DNA repair protein BRCA2 sensitizes human lung cancer cells to olaparib and cisplatin.
|
24784564 |
2014 |
Malignant neoplasm of lung
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
Our results show that LUDLU-1 lacks the mutational signature that has been previously associated with tobacco exposure in other lung cancer subtypes, and suggests that DNA-repair efficiency is adversely affected; LUDLU-1 contains somatic mutations in TP53 and BRCA2, allelic imbalance in the expression of two cancer-associated BRCA1 germline polymorphisms and reduced transcription of a potentially endogenous PARP2 inhibitor.
|
24244370 |
2013 |
Malignant neoplasm of lung
|
0.800 |
AlteredExpression
|
disease |
BEFREE |
Anchorage-dependent growth after reexpression of these genes was examined in a lung cancer cell line that originally lacked BRCA1 and BRCA2 expression.
|
17289874 |
2007 |
Malignant neoplasm of lung
|
0.800 |
GeneticVariation
|
disease |
UNIPROT |
|
|
|
Malignant neoplasm of lung
|
0.800 |
GenomicAlterations
|
disease |
CGI |
|
|
|
Malignant neoplasm of lung
|
0.800 |
CausalMutation
|
disease |
CGI |
|
|
|