Autoimmune Diseases
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Distinct molecular response patterns of activating STAT3 mutations associate with penetrance of lymphoproliferation and autoimmunity.
|
31770611 |
2020 |
Autoimmune Diseases
|
0.400 |
Biomarker
|
group |
BEFREE |
These results show STAT3 and NF-<i>κ</i>B as two important and complementary regulators of the tolerogenic behaviour of DCs, which should be considered as molecular targets in the design of DC-based suppressive immunotherapies for the treatment of autoimmune disorders.
|
31355296 |
2019 |
Autoimmune Diseases
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Activating heterozygous germline mutations in the signal transducer and activator of transcription 3 (<i>STAT3</i>) gene are associated with the rare autoimmune disorder autoimmune disease, multisystem, infantile onset (ADMIO).
|
31771449 |
2019 |
Autoimmune Diseases
|
0.400 |
Biomarker
|
group |
BEFREE |
STAT3 and STAT5 Targeting for Simultaneous Management of Melanoma and Autoimmune Diseases.
|
31569642 |
2019 |
Autoimmune Diseases
|
0.400 |
AlteredExpression
|
group |
BEFREE |
STAT3 is a central member of the JAK/STAT signaling cascade and has long been recognized for its increased transcriptional activity in cancers and autoimmune disorders but has only recently been in the spotlight for its role in the progression of kidney disease.
|
30943069 |
2019 |
Autoimmune Diseases
|
0.400 |
AlteredExpression
|
group |
BEFREE |
Signal transducer and activator of transcription 3 (STAT3) is constitutively activated in psoriatic skin inflammation and acts as a key player in the pathogenesis and progression of this autoimmune disease.
|
29949348 |
2018 |
Autoimmune Diseases
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Germinal heterozygous activating STAT3 mutations represent a novel monogenic defect associated with multi-organ autoimmune disease and, in some cases, severe growth retardation.
|
29378236 |
2018 |
Autoimmune Diseases
|
0.400 |
Biomarker
|
group |
BEFREE |
IL-6/STAT3 pathway induced deficiency of RFX1 contributes to Th17-dependent autoimmune diseases via epigenetic regulation.
|
29422534 |
2018 |
Autoimmune Diseases
|
0.400 |
Biomarker
|
group |
BEFREE |
Signal transducer and activator of transcription 3 (STAT3) has a crucial role in various autoimmune disorders including, inflammatory bowel disease (IBD).
|
30181918 |
2018 |
Autoimmune Diseases
|
0.400 |
Biomarker
|
group |
BEFREE |
Reflecting the requirement of gp130-driven STAT3 signalling for gastric tumourigenesis, submucosal TLS development was also STAT3-dependent, but independent of the cytokine IL-17 which has been linked with lymphoid neogenesis in chronic inflammation and autoimmunity.
|
29417587 |
2018 |
Autoimmune Diseases
|
0.400 |
Biomarker
|
group |
BEFREE |
Thus, our computational and experimental approach identified Fas as a regulator of the Th17-to-Th1 cell balance by controlling the availability of opposing STAT1 and STAT3 to have a direct impact on autoimmunity.
|
29562202 |
2018 |
Autoimmune Diseases
|
0.400 |
Biomarker
|
group |
BEFREE |
AT-rich interactive domain-containing protein 5a (Arid5a) is an RNA-binding protein (RBP) required for autoimmunity via stabilization of interleukin-6 (Il6) and signal transducer and activator of transcription 3 (STAT3) mRNAs.
|
29244194 |
2018 |
Autoimmune Diseases
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Germline STAT3 gain-of-function (GOF) mutations cause multiple endocrine and haematologic autoimmune disorders, lymphoproliferation, and growth impairment.
|
28253502 |
2017 |
Autoimmune Diseases
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Activating germline mutations in STAT3 were recently identified as a cause of neonatal diabetes mellitus associated with beta-cell autoimmunity.
|
28402852 |
2017 |
Autoimmune Diseases
|
0.400 |
Biomarker
|
group |
BEFREE |
Job's (hyper IgE) syndrome or inflammatory bowel disease (IBD) have now established a clear-cut role for the IL-10/STAT3 axis in immune tolerance; further understanding of these processes could lead to novel therapeutic approaches for autoimmune diseases.
|
28631311 |
2017 |
Autoimmune Diseases
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Patients with germline STAT3 GOF mutations have an increased frequency of early-onset multiorgan autoimmunity (i.e. autoimmune enteropathy, type 1 diabetes mellitus, autoimmune interstitial lung disease and autoimmune cytopenias), lymphoproliferation, short stature and, less frequently, severe recurrent infections.
|
28914637 |
2017 |
Autoimmune Diseases
|
0.400 |
PosttranslationalModification
|
group |
BEFREE |
Calcitriol, the active form of vitamin D, has been shown to decrease STAT1 and STAT3 phosphorylation in cancer cell lines and autoimmune disease mouse models.
|
27715403 |
2017 |
Autoimmune Diseases
|
0.400 |
Biomarker
|
group |
BEFREE |
Nutritional control of IL-23/Th17-mediated autoimmune disease through HO-1/STAT3 activation.
|
28290522 |
2017 |
Autoimmune Diseases
|
0.400 |
Biomarker
|
group |
BEFREE |
These observations suggest that FRA1 and JUNB are associated closely with STAT3 activation, and that this activation leads to Th17 cell differentiation in autoimmune diseases and inflammation.
|
29326694 |
2017 |
Autoimmune Diseases
|
0.400 |
GeneticVariation
|
group |
BEFREE |
This case sheds light on the emerging role of signal transducer and activator of transcription 3 gain-of-function mutation in the pathogenesis of autoimmune diseases, and further addresses the therapeutic role of interleukin-6 blocker treatment in this syndrome.
|
28153428 |
2017 |
Autoimmune Diseases
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Germline STAT3 gain-of-function mutations have recently been identified in patients with an early-onset autoimmunity/lymphoproliferative syndrome.
|
26574998 |
2016 |
Autoimmune Diseases
|
0.400 |
Biomarker
|
group |
BEFREE |
Our results broaden the spectrum of phenotypes caused by activating STAT3 mutations, highlight the role of STAT3 in the development and differentiation of multiple immune cell lineages, and strengthen the link between the STAT family of transcription factors and autoimmunity.
|
25349174 |
2015 |
Autoimmune Diseases
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Recently, germline, heterozygous mutations in STAT3 that confer a gain-of-function have been discovered and result in early-onset, multi-organ autoimmunity.
|
26280891 |
2015 |
Autoimmune Diseases
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Here, we report on 13 individuals from 10 families with lymphoproliferation and early-onset solid-organ autoimmunity associated with 9 different germline heterozygous mutations in STAT3.
|
25359994 |
2015 |
Autoimmune Diseases
|
0.400 |
Biomarker
|
group |
BEFREE |
These findings emphasize the critical role of STAT3 in autoimmune disease and contrast with the germline inactivating STAT3 mutations that result in hyper IgE syndrome.
|
25038750 |
2014 |