Squamous cell carcinoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Immunohistochemical assessment of growth factor signaling molecules: MAPK, Akt, and STAT3 pathways in oral epithelial precursor lesions and squamous cell carcinoma.
|
31062130 |
2020 |
Squamous cell carcinoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
STAT3-induced upregulation of long noncoding RNA HNF1A-AS1 promotes the progression of oral squamous cell carcinoma via activating Notch signaling pathway.
|
30404566 |
2019 |
Squamous cell carcinoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Anti-proliferative effect of 8α-tigloyloxyhirsutinolide-13-O-acetate (8αTGH) isolated from Vernonia cinerea on oral squamous cell carcinoma through inhibition of STAT3 and STAT2 phosphorylation.
|
30599904 |
2019 |
Squamous cell carcinoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
CD133 receptor mediated delivery of STAT3 inhibitor for simultaneous elimination of cancer cells and cancer stem cells in oral squamous cell carcinoma.
|
31371076 |
2019 |
Squamous cell carcinoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
STAT3- and GSK3β-mediated Mcl-1 regulation modulates TPF resistance in oral squamous cell carcinoma.
|
30395230 |
2019 |
Squamous cell carcinoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Moreover, increased PCBP1 inhibited the growth of oral squamous cell carcinoma and breast cancer cells, and the expression of STAT3 target genes.
|
31223278 |
2019 |
Squamous cell carcinoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Abnormal activation of signal transducer and activator of transcription 3 (STAT3) serves a pivotal role in oral squamous cell carcinoma (OSCC) tumor cell invasion into normal tissues or distant organs.
|
29532870 |
2018 |
Squamous cell carcinoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
2-O-Methylmagnolol Induces Apoptosis and Inhibits IL-6/STAT3 Signaling in Oral Squamous Cell Carcinoma.
|
30355952 |
2018 |
Squamous cell carcinoma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The OE33 (OAC) and OE21 (SCC) cell lines were treated with the STAT3 inhibitor, STATTIC.
|
29890775 |
2018 |
Squamous cell carcinoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Results from the patients' samples showed that the Phospho-STAT3 has a significant association with cyclin D1 overexpression in OSCC tumor samples.
|
29516928 |
2018 |
Squamous cell carcinoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
We found a negative correlation between the expression of hsa-miR-21 expression and STAT3 in oral squamous cell carcinoma.
|
29976158 |
2018 |
Squamous cell carcinoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Clinical Roles of Interleukin-6 and STAT3 in Oral Squamous Cell Carcinoma.
|
27744625 |
2017 |
Squamous cell carcinoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
STAT3 regulates hypoxia-induced epithelial mesenchymal transition in oesophageal squamous cell cancer.
|
27220595 |
2016 |
Squamous cell carcinoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
STAT3 nuclear translocation was more frequent in adenocarcinomas and squamous cell carcinomas than that of their noncancerous counterparts.
|
26432044 |
2015 |
Squamous cell carcinoma
|
0.400 |
Biomarker
|
disease |
CTD_human |
STAT3 nuclear translocation was more frequent in adenocarcinomas and squamous cell carcinomas than that of their noncancerous counterparts.
|
26432044 |
2015 |
Squamous cell carcinoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Protein inhibitor of activated signal transducer and activator of transcription 3 (STAT3) (PIAS3) is an endogenous inhibitor of STAT3 that negatively regulates STAT3 transcriptional activity and cell growth and demonstrates limited expression in the majority of human squamous cell carcinomas of the lung.
|
23959540 |
2014 |
Squamous cell carcinoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
STAT3 expression, activity and functional consequences of STAT3 inhibition in esophageal squamous cell carcinomas and Barrett's adenocarcinomas.
|
23912451 |
2014 |
Squamous cell carcinoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Here we show a clear correlation between the efficacy of anti-EGFR inhibitors with their ability to inhibit STAT3 activity in A431 epidermoid carcinoma cells and in a series of wt K-RAS expressing human colon cancer cell lines.
|
24556630 |
2014 |
Squamous cell carcinoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
STAT3 oligonucleotide inhibits tumor angiogenesis in preclinical models of squamous cell carcinoma.
|
24404126 |
2014 |
Squamous cell carcinoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Intercellular contact augments epidermal growth factor receptor (EGFR) and signal transducer and activator of transcription 3 (STAT3)-activation which increases podoplanin-expression in order to promote squamous cell carcinoma motility.
|
23266472 |
2013 |
Squamous cell carcinoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Moreover, the differences in STAT3 gene expression between squamous cell carcinoma and large cell carcinoma histopathological subtypes were observed.
|
24382554 |
2013 |
Squamous cell carcinoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
These findings indicate that basal stem/progenitor cells are the cells of origin of squamous carcinoma and that cooperation between Sox2 and microenvironment-activated Stat3 is required for Sox2-driven tumorigenesis.
|
23472872 |
2013 |
Squamous cell carcinoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Together, our findings provide evidence that ΔNp63α expression is regulated by EGFR activation through STAT3 and that the EGFR-ΔNp63α axis is crucial for proliferation of TICs present in SCCs.
|
23018838 |
2013 |
Squamous cell carcinoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
STAT5A-mediated SOCS2 expression regulates Jak2 and STAT3 activity following c-Src inhibition in head and neck squamous carcinoma.
|
22090359 |
2012 |
Squamous cell carcinoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Our results suggest that Stat3 is involved in the motility, metastasis and progression in human lingual squamous cell carcinoma, and thus, it may be a therapeutic target for human lingual squamous cell carcinoma.
|
22302289 |
2012 |