Inflammatory Bowel Diseases
|
0.400 |
AlteredExpression
|
group |
BEFREE |
In conclusion, our study demonstrated the key function of the hypoxia-associated transcription factor HIF-1α together with p-STAT3 in driving CD11b transcription in B cells and controlling B cell's protective activity in experimental inflammatory bowel disease (IBD).
|
31063937 |
2019 |
Inflammatory Bowel Diseases
|
0.400 |
Biomarker
|
group |
BEFREE |
T helper 17 (Th17)-cell differentiation triggered by interleukin-6 (IL-6) via STAT3 activation promotes inflammation in inflammatory bowel disease (IBD) patients.
|
30770344 |
2019 |
Inflammatory Bowel Diseases
|
0.400 |
Biomarker
|
group |
BEFREE |
Moreover, low level of HMGB1 was correlated with reduced nuclear STAT3 and enhanced p-STAT3 in inflamed intestine of <i>il10<sup>-/-</sup></i> mice and inflammatory bowel disease (IBD) patients.
|
30894054 |
2019 |
Inflammatory Bowel Diseases
|
0.400 |
Biomarker
|
group |
BEFREE |
A20 ameliorates inflammatory bowel disease in mice via inhibiting NF-κB and STAT3 activation.
|
29608924 |
2018 |
Inflammatory Bowel Diseases
|
0.400 |
Biomarker
|
group |
BEFREE |
Blockade of ROCK2 activity using Slx-2119 significantly suppressed proinflammatory cytokines in inflamed mucosa from IBD patients including IFX-unresponsive CD patients, and inhibited IBD CD4<sup>+</sup> T cells to differentiate into Th1 and Th17 cells through downregulating phosphorylated Stat1 and Stat3, but promoted Treg cell differentiation through upregulating phosphorylated Stat5.
|
29269245 |
2018 |
Inflammatory Bowel Diseases
|
0.400 |
Biomarker
|
group |
BEFREE |
Signal transducer and activator of transcription 3 (STAT3) has a crucial role in various autoimmune disorders including, inflammatory bowel disease (IBD).
|
30181918 |
2018 |
Inflammatory Bowel Diseases
|
0.400 |
GeneticVariation
|
group |
GWASCAT |
Genome-wide association study implicates immune activation of multiple integrin genes in inflammatory bowel disease.
|
28067908 |
2017 |
Inflammatory Bowel Diseases
|
0.400 |
AlteredExpression
|
group |
BEFREE |
The activation of STAT3 was inhibited in colon tissues and spleens of IBD mice that were treated with hucMSCs.
|
28258529 |
2017 |
Inflammatory Bowel Diseases
|
0.400 |
Biomarker
|
group |
BEFREE |
Job's (hyper IgE) syndrome or inflammatory bowel disease (IBD) have now established a clear-cut role for the IL-10/STAT3 axis in immune tolerance; further understanding of these processes could lead to novel therapeutic approaches for autoimmune diseases.
|
28631311 |
2017 |
Inflammatory Bowel Diseases
|
0.400 |
Biomarker
|
group |
BEFREE |
Especially the identification of the strong association of a series of single nucleotide polymorphisms including interleukin (IL)-23R, CCR6, signal transducer and activator of transcription 3 (Stat3) and Stat4 with IBD susceptibility point at a critical involvement of T cells and especially of IL-17a-producing Th17 cells in the immune pathogenesis of IBD.
|
27548324 |
2017 |
Inflammatory Bowel Diseases
|
0.400 |
Biomarker
|
group |
BEFREE |
To study the genetic association and epistatic interaction of the interleukin (IL)-10 and IL-10/STAT3 pathways in pediatric inflammatory bowel disease (IBD).
|
28785144 |
2017 |
Inflammatory Bowel Diseases
|
0.400 |
Biomarker
|
group |
BEFREE |
This observation supports our hypothesis that HO-1 is regulated by the IL-10/STAT3 pathway and that both genes (IL10 and STAT3) could be involved in the pathogenesis of inflammatory bowel disease.
|
28770550 |
2017 |
Inflammatory Bowel Diseases
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Germline loss-of-function mutations are known to cause hyper-IgE immunodeficiency (autosomal dominant hyper IgE syndrome), whereas somatic gain-of-function mutations have been described in large granular cell leukemia, and polymorphisms in STAT3 have been associated with inflammatory bowel disease and other solid organ tumors.
|
26574998 |
2016 |
Inflammatory Bowel Diseases
|
0.400 |
GeneticVariation
|
group |
GWASCAT |
Identification of Loci at 1q21 and 16q23 That Affect Susceptibility to Inflammatory Bowel Disease in Koreans.
|
27569725 |
2016 |
Inflammatory Bowel Diseases
|
0.400 |
Biomarker
|
group |
BEFREE |
Immune deficiency vs. immune excess in inflammatory bowel diseases-STAT3 as a rheo-STAT of intestinal homeostasis.
|
26232455 |
2016 |
Inflammatory Bowel Diseases
|
0.400 |
AlteredExpression
|
group |
BEFREE |
STAT3 is activated in chronically inflamed intestines in human inflammatory bowel diseases and in colitis-associated colon cancer.
|
27237322 |
2016 |
Inflammatory Bowel Diseases
|
0.400 |
GeneticVariation
|
group |
BEFREE |
The aim of our study is to investigate the involvement of IL23R, JAK2, and STAT3 polymorphisms in inflammatory bowel diseases in a Turkish population.
|
27852544 |
2016 |
Inflammatory Bowel Diseases
|
0.400 |
Biomarker
|
group |
BEFREE |
To establish the prevalence of the single nucleotide polymorphisms (SNPs) of endoplasmic reticulum aminopeptidase 1 (ERAP1), IL-23 receptor (IL-23R), signal transducer and activator of transcription 3 (STAT-3) and Janus kinase 2 (JAK-2) in ankylosing spondylitis (AS) and inflammatory bowel disease (IBD) in a Turkish population.
|
27458846 |
2016 |
Inflammatory Bowel Diseases
|
0.400 |
AlteredExpression
|
group |
BEFREE |
Therefore, mTORC1 signaling critically protects against inflammatory bowel disease through modulation of inflammation-induced Stat3 activity.
|
26026060 |
2015 |
Inflammatory Bowel Diseases
|
0.400 |
GeneticVariation
|
group |
GWASCAT |
Association analyses identify 38 susceptibility loci for inflammatory bowel disease and highlight shared genetic risk across populations.
|
26192919 |
2015 |
Inflammatory Bowel Diseases
|
0.400 |
Biomarker
|
group |
BEFREE |
Additional suggestive associations (P < 4.2 × 10(-5)) were observed between Crohn's disease and IBD and African-specific SNPs in STAT5A and STAT3; between IBD and SNPs in IL23R, IL12B, and C2orf43; and between ulcerative colitis and SNPs near HDAC11 and near LINC00994.
|
26278503 |
2015 |
Inflammatory Bowel Diseases
|
0.400 |
Biomarker
|
group |
BEFREE |
Some IBD associated genes are involved in innate immunity, in the autophagy and in the inflammatory response such as NOD2, ATG16L1 and IL23R, while other are implicated in immune mediated disease (STAT3) and in susceptibility to mycobacterium infection (IL12B).
|
26604638 |
2015 |
Inflammatory Bowel Diseases
|
0.400 |
Biomarker
|
group |
BEFREE |
The cis-expression quantitative trait locus analysis showed little evidence for correlation between genetic risk load and mRNA expression of Th17/IL23 genes, because we identified for only 2 of 22 Th17/IL23 genes a cis-expression quantitative trait locus single nucleotide polymorphism that is also associated to IBD (STAT3 and CCR6).
|
24662057 |
2014 |
Inflammatory Bowel Diseases
|
0.400 |
GeneticVariation
|
group |
BEFREE |
These data suggest that the STAT3 locus is associated with both IBD and cancer.
|
25132422 |
2014 |
Inflammatory Bowel Diseases
|
0.400 |
Biomarker
|
group |
BEFREE |
STAT3 tyrosine phosphorylation (pSTAT3) was measured in circulating leukocytes by flow cytometry, and mechanisms regulating STAT3 activation were tested in IBD Epstein-Barr virus (EBV)-transformed lymphocytes (EBL).
|
22197944 |
2012 |