|
Prostatic Neoplasms
|
0.400 |
Biomarker
|
group |
BEFREE |
Here we discovered that ABI1 inhibits EMT through suppressing FYN-STAT3 activation downstream from non-canonical WNT signaling thus providing a novel mechanism of prostate tumor suppression.
|
31530281 |
2019 |
|
Prostatic Neoplasms
|
0.400 |
AlteredExpression
|
group |
BEFREE |
Immunohistochemistry studies showed increased levels of STAT3 and IL-6, but low levels of programmed cell death protein 4 (PDCD4), in prostate tumor epithelial cells compared to adjacent perinormal prostate epithelial cells.
|
28467474 |
2017 |
|
Prostatic Neoplasms
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Human prostate tumors with IL-6 elevation and loss of ESE3/EHF were associated with STAT3 activation and displayed upregulation of genes related to cell adhesion, cancer stem-like and metastatic spread.
|
27732936 |
2016 |
|
Prostatic Neoplasms
|
0.400 |
Biomarker
|
group |
BEFREE |
MicroRNA-424 impairs ubiquitination to activate STAT3 and promote prostate tumor progression.
|
27820701 |
2016 |
|
Prostatic Neoplasms
|
0.400 |
Biomarker
|
group |
CTD_human |
Niclosamide suppresses cell migration and invasion in enzalutamide resistant prostate cancer cells via Stat3-AR axis inhibition.
|
25970160 |
2015 |
|
Prostatic Neoplasms
|
0.400 |
Biomarker
|
group |
BEFREE |
To develop a potent strategy to increase therapeutic efficacy and reduce drug resistance in prostate cancer therapy, we combined two anti-cancer agents: T40214 (a p-Stat3 inhibitor) and JG244 (a HIF-1α inhibitor) together to treat nude mice bearing human prostate tumor (DU145) and immunocompetent mice (C57BL/6) bearing murine prostate tumor (TRAMP-C2).
|
21480310 |
2011 |
|
Prostatic Neoplasms
|
0.400 |
Biomarker
|
group |
BEFREE |
Cooperation between Stat3 and Akt signaling leads to prostate tumor development in transgenic mice.
|
21390188 |
2011 |
|
Prostatic Neoplasms
|
0.400 |
Biomarker
|
group |
LHGDN |
The Fer tyrosine kinase cooperates with interleukin-6 to activate signal transducer and activator of transcription 3 and promote human prostate cancer cell growth.
|
19147545 |
2009 |
|
Prostatic Neoplasms
|
0.400 |
Biomarker
|
group |
LHGDN |
Stat3 promotes metastatic progression of prostate cancer.
|
18483213 |
2008 |
|
Prostatic Neoplasms
|
0.400 |
Biomarker
|
group |
BEFREE |
Blockade of Stat3 using specific short hairpin RNAs (shRNA) can significantly reduce prostate tumor growth in mice.
|
18223232 |
2008 |
|
Prostatic Neoplasms
|
0.400 |
AlteredExpression
|
group |
LHGDN |
Protein kinase Cepsilon interacts with signal transducers and activators of transcription 3 (Stat3), phosphorylates Stat3Ser727, and regulates its constitutive activation in prostate cancer.
|
17875724 |
2007 |
|
Prostatic Neoplasms
|
0.400 |
Biomarker
|
group |
CTD_human |
Interferon-gamma-induced dephosphorylation of STAT3 and apoptosis are dependent on the mTOR pathway.
|
16427044 |
2006 |
|
Prostatic Neoplasms
|
0.400 |
AlteredExpression
|
group |
BEFREE |
Using immunohistochemical staining of tissue microarrays, we showed that these targets are enriched in breast and prostate tumors harboring activated STAT3.
|
15958548 |
2005 |
|
Prostatic Neoplasms
|
0.400 |
AlteredExpression
|
group |
BEFREE |
Down-regulation of signal transducer and activator of transcription 3 expression using vector-based small interfering RNAs suppresses growth of human prostate tumor in vivo.
|
16144938 |
2005 |
|
Prostatic Neoplasms
|
0.400 |
Biomarker
|
group |
LHGDN |
A SOCS-1 peptide mimetic inhibits both constitutive and IL-6 induced activation of STAT3 in prostate cancer cells.
|
15688010 |
2005 |
|
Prostatic Neoplasms
|
0.400 |
Biomarker
|
group |
LHGDN |
Using immunohistochemical staining of tissue microarrays, we showed that these targets are enriched in breast and prostate tumors harboring activated STAT3.
|
15958548 |
2005 |
|
Prostatic Neoplasms
|
0.400 |
Biomarker
|
group |
CTD_human |
Cross-talk between endocrine-disrupting chemicals and cytokine signaling through estrogen receptors.
|
14975756 |
2004 |
|
Prostatic Neoplasms
|
0.400 |
AlteredExpression
|
group |
LHGDN |
Stat3 activation in prostatic carcinomas.
|
11987152 |
2002 |
|
Prostatic Neoplasms
|
0.400 |
AlteredExpression
|
group |
BEFREE |
Constitutive activation of Stat3 in human prostate tumors and cell lines: direct inhibition of Stat3 signaling induces apoptosis of prostate cancer cells.
|
12438264 |
2002 |