Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Squamous cell carcinoma of the head and neck
0.400 Biomarker disease BEFREE The NGF/TrkA axis could promote HNSCC cell dissemination and trigger EMT via STAT3 activation. 31838083 2020
Squamous cell carcinoma of the head and neck
0.400 Biomarker disease BEFREE We reported that signal transducer and activator of transcription factor 3 (STAT3)/vascular endothelial growth factor receptor 2 (VEGFR2) axis served as the downstream signaling of EZH2 and mediated EMT in HNSCC. 31545422 2019
Squamous cell carcinoma of the head and neck
0.400 AlteredExpression disease BEFREE Persistent activation of STAT3 and deregulation of its signaling has been observed in various human cancers including head and neck squamous cell carcinoma (HNSCC). 31575007 2019
Squamous cell carcinoma of the head and neck
0.400 Biomarker disease BEFREE Taken together, these results indicate that C188-9 could be a promising therapeutic strategy for patients suffered from HNSCC by suppressing the STAT3 pathway. 30870229 2019
Squamous cell carcinoma of the head and neck
0.400 Biomarker disease BEFREE STOML2 as a novel prognostic biomarker modulates cell proliferation, motility and chemo-sensitivity via IL6-Stat3 pathway in head and neck squamous cell carcinoma. 30899371 2019
Squamous cell carcinoma of the head and neck
0.400 Biomarker disease BEFREE Correction: Small-molecule inhibition of STAT3 in radioresistant head and neck squamous cell carcinoma. 30899429 2019
Squamous cell carcinoma of the head and neck
0.400 Biomarker disease BEFREE LincRNA-p21 acted as a tumor suppressor in HNSCC progression, which was attributed to direct binding to STAT3 and blocking of JAK2/STAT3 signaling. 30857539 2019
Squamous cell carcinoma of the head and neck
0.400 Biomarker disease BEFREE In summary, our discoveries illuminate how aberrant STAT3 activation confers an oncogenic function in HNSCC and therefore may provide a theoretical foundation for STAT3 as a therapeutic target in HNSCC. 30118844 2018
Squamous cell carcinoma of the head and neck
0.400 AlteredExpression disease BEFREE Stathmin 1 expression correlates with PD-L1, TIM3, VISTA, B7-H3, B7-H4, LAG-3 and p-STAT3 expression in HNSCC. 29847156 2018
Squamous cell carcinoma of the head and neck
0.400 Biomarker disease BEFREE To determine the role of JAK2/STAT3 pathway in tumor microenvironment of HNSCC, we utilized AG490 (an inhibitor of JAK2/STAT3) for further research. 29215754 2018
Squamous cell carcinoma of the head and neck
0.400 Biomarker disease BEFREE Repressed GPRC5A associates with increased tumor grade and activated STAT3, which may be used as a prognostic marker for tumor progression of HNSCC. 28270740 2017
Squamous cell carcinoma of the head and neck
0.400 Biomarker disease BEFREE PD-1/PD-L1 overexpression was found to be significantly associated with p-STAT3 in human and mouse HNSCC. 28605599 2017
Squamous cell carcinoma of the head and neck
0.400 Biomarker disease BEFREE Importantly, we found that active STAT3 in tumors directly correlated with response to cisplatin-based chemoradiotherapy in HNSCC patients (<i>p</i> = 0.006). 28903353 2017
Squamous cell carcinoma of the head and neck
0.400 Biomarker disease BEFREE In this study, we show that HJC0152, a recently developed anticancer agent and a STAT3 signaling inhibitor, exhibits promising antitumor effects against HNSCC both <i>in vitro</i> and <i>in vivo</i> via inactivating STAT3 and downstream miR-21/β-catenin axis. 28138036 2017
Squamous cell carcinoma of the head and neck
0.400 Biomarker disease BEFREE We further show that PTPRT promoter methylation is significantly associated with sensitivity to STAT3 inhibition in HNSCC cells, suggesting that PTPRT promoter methylation may serve as a predictive biomarker for responsiveness to STAT3 inhibitors in clinical development. 25982282 2016
Squamous cell carcinoma of the head and neck
0.400 Biomarker disease CTD_human We found that HN3 and FaDu cells expressed strongly phosphorylated STAT3 on both tyrosine 705 and serine 727 residues as compared to other SCCHN cells. 27064016 2016
Squamous cell carcinoma of the head and neck
0.400 Biomarker disease BEFREE Since STAT3 activation is involved in tumor progression and metastasis, we investigated the effect of GSNO in cell culture and mouse xenograft model of head and neck squamous cell carcinoma (HNSCC). 28162277 2015
Squamous cell carcinoma of the head and neck
0.400 AlteredExpression disease BEFREE Since STAT3 and NF-κB are key transcription factors involved in tumor progression, chemoresistance, and metastasis of head and neck cancer, we investigated the effect of GSNO in cell culture and mouse xenograft models of head and neck squamous cell carcinoma (HNSCC). 26177470 2015
Squamous cell carcinoma of the head and neck
0.400 Biomarker disease BEFREE We additionally found that PTPRD mRNA expression does not correlate with pSTAT3 expression, suggesting that alterations that manifest through altered mRNA expression, including hypermethylation and gene copy number alterations, do not significantly contribute to STAT3 overactivation in HNSCC. 26267899 2015
Squamous cell carcinoma of the head and neck
0.400 AlteredExpression disease BEFREE Immunohistochemical analysis confirmed that HPV- HNSCC is characterized by co-activated STAT3 and NF-κB pathways and functional studies demonstrate that this phenotype can be effectively targeted with combined anti-NF-κB and anti-STAT therapies. 25857630 2015
Squamous cell carcinoma of the head and neck
0.400 Biomarker disease BEFREE JAK kinase inhibition abrogates STAT3 activation and head and neck squamous cell carcinoma tumor growth. 25810010 2015
Squamous cell carcinoma of the head and neck
0.400 Biomarker disease BEFREE In conclusion, JAk2/STAT3 plays a key role in CCR7 regulating SCCHN metastasis. 25405202 2014
Squamous cell carcinoma of the head and neck
0.400 AlteredExpression disease BEFREE PTPR mutations are most common and are associated with significantly increased phospho-STAT3 expression in HNSCC tumors. 24395800 2014
Squamous cell carcinoma of the head and neck
0.400 Biomarker disease BEFREE Signal transducer and activator of transcription 3 (STAT3) has shown to play a critical role in head and neck squamous cell carcinoma (HNSCC) and we have recently completed clinical trials of STAT3 decoy oligonucleotide in patients with recurrent or metastatic HNSCC. 24404126 2014
Squamous cell carcinoma of the head and neck
0.400 Biomarker disease BEFREE The findings were further supported using chemical inhibitors of STAT3 activity (a downstream effecter of uPAR signaling pathway), showing that STAT3 suppression altered HNSCC cell line cisplatin sensitivity. 23661500 2014