Lung Neoplasms
|
0.500 |
Biomarker
|
group |
BEFREE |
Our findings strongly suggest that autophagy inhibition could be a strategy for treating LKB1-deficient lung tumors.
|
30692209 |
2019 |
Lung Neoplasms
|
0.500 |
Biomarker
|
group |
BEFREE |
(2018) identify induction of glutamate dehydrogenase as a critical metabolic adaptation in matrix-detached cancer cells that is required for metastasis of LKB1-deficient lung tumors.
|
29304329 |
2018 |
Lung Neoplasms
|
0.500 |
Biomarker
|
group |
BEFREE |
STK11/LKB1 Deficiency Promotes Neutrophil Recruitment and Proinflammatory Cytokine Production to Suppress T-cell Activity in the Lung Tumor Microenvironment.
|
26833127 |
2016 |
Lung Neoplasms
|
0.500 |
Biomarker
|
group |
BEFREE |
When administered as a single agent or in combination with the standard-of-care drug carboplatin, ND-646 markedly suppressed lung tumor growth in the Kras;Trp53<sup>-/-</sup> (also known as KRAS p53) and Kras;Stk11<sup>-/-</sup> (also known as KRAS Lkb1) mouse models of NSCLC.
|
27643638 |
2016 |
Lung Neoplasms
|
0.500 |
Biomarker
|
group |
BEFREE |
Finally, combined treatment with LKB1 and FUS1 prolonged overall survival in lung tumor-bearing mice.
|
24659339 |
2014 |
Lung Neoplasms
|
0.500 |
Biomarker
|
group |
BEFREE |
Expression of Sox2, frequently amplified in human SCC, specifically cooperates with loss of Lkb1 to promote squamous lung tumors.
|
24953650 |
2014 |
Lung Neoplasms
|
0.500 |
GeneticVariation
|
group |
BEFREE |
Our preliminary data showed that LKB1 loss was associated with p53 mutation in lung tumors from Taiwanese adenocarcinoma patients and p53 transcription is directly regulated by NKX2-1.
|
23995788 |
2014 |
Lung Neoplasms
|
0.500 |
Biomarker
|
group |
BEFREE |
In summary, these results demonstrate that LKB1 regulates the Wnt pathway through a direct interaction with APC to suppress the tumorigenic/metastatic potential of lung tumors.
|
24448687 |
2014 |
Lung Neoplasms
|
0.500 |
Biomarker
|
group |
BEFREE |
In humans, the LKB1 gene is located on the short arm of chromosome 19, which is frequently deleted in lung tumors.
|
21516316 |
2011 |
Lung Neoplasms
|
0.500 |
AlteredExpression
|
group |
BEFREE |
These studies revealed that SRC is activated in Lkb1-deficient primary and metastatic lung tumors, and that the combined inhibition of SRC, PI3K, and MEK1/2 resulted in synergistic tumor regression.
|
20541700 |
2010 |
Lung Neoplasms
|
0.500 |
Biomarker
|
group |
BEFREE |
Up-regulated LOX expression triggers excess collagen deposition in Lkb1-deficient lung tumors, and thereafter results in enhanced cancer cell proliferation and invasiveness through activation of β1 integrin signaling.
|
20956321 |
2010 |
Lung Neoplasms
|
0.500 |
Biomarker
|
group |
BEFREE |
Data from several independent groups have provided information about the profiles of lung tumors with LKB1 inactivation and it is generally agreed that this alteration strongly predominates in non-small cell lung cancer, in particular adenocarcinomas, in smokers.
|
19176640 |
2009 |
Lung Neoplasms
|
0.500 |
GeneticVariation
|
group |
LHGDN |
LKB1/KRAS mutant lung cancers constitute a genetic subset of NSCLC with increased sensitivity to MAPK and mTOR signalling inhibition.
|
19165201 |
2009 |
Lung Neoplasms
|
0.500 |
Biomarker
|
group |
BEFREE |
Results indicate that the LKB1 gene is changed in a certain proportion of nonsmall cell lung tumors, predominately in advanced squamous lung carcinoma.
|
19229701 |
2009 |
Lung Neoplasms
|
0.500 |
Biomarker
|
group |
LHGDN |
The tumor suppressor LKB1 regulates lung cancer cell polarity by mediating cdc42 recruitment and activity.
|
18245474 |
2008 |
Lung Neoplasms
|
0.500 |
Biomarker
|
group |
LHGDN |
LKB1 and lung cancer: more than the usual suspects.
|
18483235 |
2008 |
Lung Neoplasms
|
0.500 |
GeneticVariation
|
group |
LHGDN |
LKB1 gene mutations in Japanese lung cancer patients.
|
17711506 |
2007 |
Lung Neoplasms
|
0.500 |
Biomarker
|
group |
CTD_human |
Expression profiling in human lung cancer cell lines and mouse lung tumours identified a variety of metastasis-promoting genes, such as NEDD9, VEGFC and CD24, as targets of LKB1 repression in lung cancer.
|
17676035 |
2007 |
Lung Neoplasms
|
0.500 |
GeneticVariation
|
group |
BEFREE |
LKB1, mutated in Peutz-Jeghers and in sporadic lung tumours, phosphorylates a group of protein kinases named AMP-activated protein kinase (AMPK)-related kinases.
|
16953221 |
2007 |
Lung Neoplasms
|
0.500 |
AlteredExpression
|
group |
LHGDN |
LKB1/STK11 suppresses cyclooxygenase-2 induction and cellular invasion through PEA3 in lung cancer.
|
16912160 |
2006 |
Lung Neoplasms
|
0.500 |
Biomarker
|
group |
BEFREE |
Because germ-line mutations at LKB1/STK11 result in the Peutz-Jeghers syndrome and an increased risk of cancer, we performed a detailed genetic screen of the LKB1/STK11 gene in lung tumors.
|
12097271 |
2002 |
Lung Neoplasms
|
0.500 |
Biomarker
|
group |
HPO |
|
|
|