STK11, serine/threonine kinase 11, 6794

N. diseases: 372; N. variants: 145
Disease: melanoma ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0025202
Disease: melanoma
melanoma 		0.700 Biomarker disease BEFREE Ectopic LKB1 induces growth arrest by upregulating p21/cyclin dependent kinase inhibitor 1A (WAF1) in LKB1 deficient cervical and melanoma cancer cell lines. 29963200 2018
CUI: C0025202
Disease: melanoma
melanoma 		0.700 Biomarker disease BEFREE Thus, our findings indicate a probable explanation on LKB1 function as a tumor suppressor in melanoma and a new therapeutic strategy for melanoma by targeting on BRAF and LKB1 together. 29371951 2017
CUI: C0025202
Disease: melanoma
melanoma 		0.700 Biomarker disease BEFREE LKB1 (also known as STK11) is a potent tumor suppressor in solid tumors, such as melanoma and lung adenocarcinoma, but inactivation in hematopoietic cells causes cell death without signs of tumorigenesis. 28435024 2017
CUI: C0025202
Disease: melanoma
melanoma 		0.700 PosttranslationalModification disease BEFREE Multivariate COX regression analysis indicated that LKB1 promoter methylation was an independent prognostic factor for overall survival in patients with melanoma. 28781649 2017
CUI: C0025202
Disease: melanoma
melanoma 		0.700 GeneticVariation disease BEFREE Simultaneous Cdkn2a and Lkb1 inactivation in Braf(V600E) melanocytes results in activation of both mTORC1 and mTORC2/Akt, inducing rapid melanoma formation in mice. 25584893 2015
CUI: C0025202
Disease: melanoma
melanoma 		0.700 Biomarker disease BEFREE Inhibition of the LKB1-MARK pathway facilitated invasive motility, suggesting that loss of the ability to sense inhibitory matrix cues may promote melanoma invasion. 25349262 2014
CUI: C0025202
Disease: melanoma
melanoma 		0.700 AlteredExpression disease BEFREE LKB1/STK11 inactivation leads to expansion of a prometastatic tumor subpopulation in melanoma. 22698401 2012
CUI: C0025202
Disease: melanoma
melanoma 		0.700 GeneticVariation disease BEFREE The STK11/LKB1 gene encodes a ubiquitously expressed serine/threonine kinase that is mutated in multiple sporadic cancers including non-small cell lung carcinomas, pancreatic cancers, and melanomas. 20193846 2010
CUI: C0025202
Disease: melanoma
melanoma 		0.700 AlteredExpression disease BEFREE Furthermore, expression of a phosphorylation-deficient mutant of LKB1 allows activation of AMPK and inhibits melanoma cell proliferation and anchorage-independent cell growth. 19187764 2009
CUI: C0025202
Disease: melanoma
melanoma 		0.700 GeneticVariation disease BEFREE Somatic mutations in Lkb1 are observed in sporadic pulmonary, pancreatic and biliary cancers and melanomas. 19029933 2008
CUI: C0025202
Disease: melanoma
melanoma 		0.700 Biomarker disease BEFREE Finally we demonstrate that all 6 LKB1/STK11 variants, in contrast to wild type LKB1/STK11, are unable to suppress the growth of melanoma G361 cells. 12552571 2003
CUI: C0025202
Disease: melanoma
melanoma 		0.700 AlteredExpression disease LHGDN Finally we demonstrate that all 6 LKB1/STK11 variants, in contrast to wild type LKB1/STK11, are unable to suppress the growth of melanoma G361 cells. 12552571 2003
CUI: C0025202
Disease: melanoma
melanoma 		0.700 Biomarker disease BEFREE Our data suggest that LKB1/STK11 may contribute to tumorigenesis in a small fraction of malignant melanomas. 10208439 1999
CUI: C0025202
Disease: melanoma
melanoma 		0.700 GeneticVariation disease BEFREE Although PJS patients are not known to have an excess of skin tumors, if the freckles of PJS patients are actually small, benign tumors, LKB1/STK11 mutations must provide these lesions with a selective advantage, and similar mutations might also give a selective advantage to related malignant tumors, such as melanomas. 10201537 1999
CUI: C0025202
Disease: melanoma
melanoma 		0.700 GeneticVariation disease CLINVAR Somatic mutation of the Peutz-Jeghers syndrome gene, LKB1/STK11, in malignant melanoma. 10208439 1999
CUI: C0025202
Disease: melanoma
melanoma 		0.700 GeneticVariation disease BEFREE Germline mutations in BRCA2 have been shown to predispose to both breast and pancreatic cancer, germline mutations in p16 to melanoma and pancreatic cancer (the FAMMM syndrome), and genetic mutations in STK11/LKB1 to pancreatic cancer in patients with the Peutz-Jeghers Syndrome (PJS). 10436789 1999
CUI: C0025202
Disease: melanoma
melanoma 		0.700 GeneticVariation disease BEFREE Six melanoma and eight myeloma cell lines were scrutinized for LKB1 somatic mutations by genomic sequencing. 10079245 1999
CUI: C0025202
Disease: melanoma
melanoma 		0.700 CausalMutation disease CGI
CUI: C0025202
Disease: melanoma
melanoma 		0.700 CausalMutation disease CLINVAR
CUI: C0025202
Disease: melanoma
melanoma 		0.700 GeneticVariation disease UNIPROT