Malignant neoplasm of lung
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Mechanistically, we uncovered that autophagy was induced upon loss of <i>circHIPK3</i> via the <i>MIR124-3p</i>-STAT3-PRKAA/AMPKa axis in STK11 mutant lung cancer cell lines (A549 and H838).
|
31232177 |
2020 |
Malignant neoplasm of lung
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
We developed a mouse model for <i>Lkb1</i>-deficient lung cancer with conditional deletion of essential autophagy gene <i>Atg7</i> to test whether autophagy compensates for LKB1 loss for tumor cells to survive energy crises.
|
30692209 |
2019 |
Malignant neoplasm of lung
|
0.600 |
Biomarker
|
disease |
BEFREE |
Dual molecular targeted therapy for mTOR and PI3K may be a promising therapeutic strategy in the specific population of patients with lung cancer with LKB1 loss.
|
30825612 |
2019 |
Malignant neoplasm of lung
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Tumor Suppressor LKB1 inhibits both the mRNA Expression and the Amplification of hTERC by the Phosphorylation of YAP in Lung Cancer Cells.
|
31333780 |
2019 |
Malignant neoplasm of lung
|
0.600 |
Biomarker
|
disease |
BEFREE |
Co-occurring genomic alterations, particularly in tumour suppressor genes such as TP53 and LKB1 (also known as STK11), have emerged as core determinants of the molecular and clinical heterogeneity of oncogene-driven lung cancer subgroups through their effects on both tumour cell-intrinsic and non-cell-autonomous cancer hallmarks.
|
31406302 |
2019 |
Malignant neoplasm of lung
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Evading the STING: LKB1 Loss Leads to STING Silencing and Immune Escape in KRAS-Mutant Lung Cancers.
|
30626603 |
2019 |
Malignant neoplasm of lung
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Inactivated mutations of LKB1, observed in 20-30% of nonsmall cell lung cancers (NSCLC), contribute significantly to lung cancer malignancy progression.
|
31217475 |
2019 |
Malignant neoplasm of lung
|
0.600 |
Biomarker
|
disease |
BEFREE |
The aim of this review is to discuss interactions of LKB1 with the tumor microenvironment and the potential applications of this knowledge in predicting response to treatment in lung cancer.
|
30995715 |
2019 |
Malignant neoplasm of lung
|
0.600 |
Biomarker
|
disease |
BEFREE |
In vivo study also showed that Shh signaling pathway was involved in the modulation of LKB1 on the metastasis and angiogenesis of lung cancer.
|
30784288 |
2019 |
Malignant neoplasm of lung
|
0.600 |
Biomarker
|
disease |
BEFREE |
4-hydroxyphenylpyruvate dioxygenase promotes lung cancer growth via pentose phosphate pathway (PPP) flux mediated by LKB1-AMPK/HDAC10/G6PD axis.
|
31285420 |
2019 |
Malignant neoplasm of lung
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
SIGNIFICANCE: Oncogenic <i>KRAS</i>-mutant lung cancers remain treatment-refractory and are resistant to ICB in the setting of LKB1 loss.
|
30297358 |
2019 |
Malignant neoplasm of lung
|
0.600 |
Biomarker
|
disease |
BEFREE |
Although loss-of-function mutations involving the tumor suppressor gene, <i><i>STK11</i> (LKB1)</i> are important in lung cancer progression, <i>
|
31697874 |
2019 |
Malignant neoplasm of lung
|
0.600 |
Biomarker
|
disease |
BEFREE |
Targeted therapies for LKB1-inactivated lung cancer are currently unavailable.
|
30423141 |
2018 |
Malignant neoplasm of lung
|
0.600 |
Biomarker
|
disease |
BEFREE |
Our in vivo study also showed that LKB1 inhibited lung cancer growth in vivo and modulated Shh signaling pathway.
|
29573522 |
2018 |
Malignant neoplasm of lung
|
0.600 |
Biomarker
|
disease |
BEFREE |
Our study provides insight into the molecular mechanism by which GDH1-mediated metabolic reprogramming of glutaminolysis mediates lung cancer metastasis and offers a therapeutic strategy for patients with LKB1-deficient lung cancer.
|
29249655 |
2018 |
Malignant neoplasm of lung
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
LKB1 loss-of-function somatic mutations are frequently observed in sporadic types of cancer, particularly in lung cancer.
|
29963200 |
2018 |
Malignant neoplasm of lung
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Moreover, mutations and misregulation of LKB1 have been reported to occur in most types of tumors and are among the most common aberrations in lung cancer.
|
29540834 |
2018 |
Malignant neoplasm of lung
|
0.600 |
Biomarker
|
disease |
BEFREE |
These pathways are clinically prognostic and predictive, including the TP53-AXIN-ARHGEF17 combination in liver and CYLC2-STK11-STK11IP in lung cancer, which we validate in independent cohorts.
|
30297789 |
2018 |
Malignant neoplasm of lung
|
0.600 |
Biomarker
|
disease |
BEFREE |
Liver kinase B1 (LKB1) as a tumor suppression gene that is associated with various kinds of cancers, including lung cancer.
|
30033530 |
2018 |
Malignant neoplasm of lung
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
PLAG1-mediated GDH1 upregulation promotes LKB1-deficient lung cancer anoikis resistance.
|
29305497 |
2018 |
Malignant neoplasm of lung
|
0.600 |
Biomarker
|
disease |
BEFREE |
In addition, exosomes isolated from H460 cells with stable restoration of LKB1 had much higher ability in stimulating lung cancer cell migration than did those from H460 cells lacking LKB1.
|
29138862 |
2018 |
Malignant neoplasm of lung
|
0.600 |
Biomarker
|
disease |
BEFREE |
We used a mouse lung cancer model with metastasis driven by conditionally activated Kras and concurrent tumor suppressor Lkb1 loss (Kras<sup>G12D</sup>/ Lkb1<sup>-/-</sup> model) and a similar model of lung cancer that does not metastasize, driven by conditionally activated Kras alone (Kras<sup>G12D</sup> model).
|
29909489 |
2018 |
Malignant neoplasm of lung
|
0.600 |
Biomarker
|
disease |
BEFREE |
Further, CP alone or in combination with rapamycin strongly inhibited the in vitro and in vivo growth of tumors harboring mutations in KEAP1 or both KEAP1 and LKB1 that are frequently observed in lung cancer.
|
28504720 |
2017 |
Malignant neoplasm of lung
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Erratum: Lkb1 inactivation drives lung cancer lineage switching governed by Polycomb Repressive Complex 2.
|
28598439 |
2017 |
Malignant neoplasm of lung
|
0.600 |
Biomarker
|
disease |
BEFREE |
Our study also provides new evidence to support the critical role of liver kinase B1 in the pathogenesis of human papillomavirus-related lung cancer and suggests novel therapeutic targets.
|
28720067 |
2017 |