TAC1, tachykinin precursor 1, 6863

N. diseases: 478; N. variants: 0
Disease: Depressive disorder ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0011581
Disease: Depressive disorder
Depressive disorder 		0.400 Biomarker disease BEFREE Migraine headaches are theorized to cause aura and symptoms via spreading cortical depression that ultimately results in substance P release, alterations in blood flow, and neurogenic inflammation. 31629154 2020
CUI: C0011581
Disease: Depressive disorder
Depressive disorder 		0.400 Biomarker disease BEFREE Through activation of NK<sub>1</sub>R, substance P modulates a wide variety of physiological and disease processes including nociception, inflammation, and depression. 30538204 2018
CUI: C0011581
Disease: Depressive disorder
Depressive disorder 		0.400 Biomarker disease BEFREE Our results show a significant upregulation of MAOA and TAC1 in the medial area frontopolaris which is a node in the limbic-cortical network and known to be susceptible for gray matter loss and behavioral dysfunction in patients with depression. 29478144 2018
CUI: C0011581
Disease: Depressive disorder
Depressive disorder 		0.400 GeneticVariation disease BEFREE We quantified Tacr1 (neurokinin-1 receptor gene) and Avp (vasopressin peptide gene) mRNA in brain regions involved in depression, addiction and social behavior. 28150369 2018
CUI: C0011581
Disease: Depressive disorder
Depressive disorder 		0.400 Biomarker disease BEFREE We consider our findings to contribute to the neurobiological evidence on the association between SP and brain structural changes in depression, which may be related with the pathophysiology and treatment of MDD. 28852030 2017
CUI: C0011581
Disease: Depressive disorder
Depressive disorder 		0.400 Biomarker disease BEFREE More recently, SP and the NK1R have gained attention for their role in complex psychiatric processes including stress, anxiety, and depression. 29056150 2017
CUI: C0011581
Disease: Depressive disorder
Depressive disorder 		0.400 AlteredExpression disease BEFREE The study aimed at assessing the concentrations of ADMA, carbonyl groups, CAT and NKA in patients with varying levels of depression severity, PTSD, and depression concurrent with PTSD. 28554099 2017
CUI: C0011581
Disease: Depressive disorder
Depressive disorder 		0.400 Biomarker disease PSYGENET In this review, we update the involvement of the SP/NK-1 receptor system in the physiopathology of the above-mentioned pathologies and we suggest valuable future therapeutic interventions involving the use of NK-1 receptor antagonists, particularly in the treatment of emesis, depression, cancer, neural degeneration, inflammatory bowel disease, viral infection and pruritus, in which that system is upregulated. 24705689 2014
CUI: C0011581
Disease: Depressive disorder
Depressive disorder 		0.400 Biomarker disease PSYGENET The present studies indicate that alterations in substance P/NK1 receptor system underlie, at least in part, the behavioural and monoaminergic changes in this animal model of depression. 22155476 2012
CUI: C0011581
Disease: Depressive disorder
Depressive disorder 		0.400 Biomarker disease PSYGENET Molecular evidence for BDNF- and GABA-related dysfunctions in the amygdala of female subjects with major depression. 21912391 2012
CUI: C0011581
Disease: Depressive disorder
Depressive disorder 		0.400 Biomarker disease PSYGENET Taken together, these data are in line with behavioural experiments showing ameliorating effects of NK1 and NK2 receptor antagonists against anxiety and depression-like symptoms in rodents, and therefore further implicate the tachykinin systems in the pathophysiology of depression and adult life psychopathology. 17477887 2008
CUI: C0011581
Disease: Depressive disorder
Depressive disorder 		0.400 Biomarker disease PSYGENET However, studies on anxiety and depression-related behaviors have now been performed in mouse mutants deficient in NK1 receptor or SP and NKA. 16594257 2005
CUI: C0011581
Disease: Depressive disorder
Depressive disorder 		0.400 Biomarker disease BEFREE Increasing evidence suggests that substance P (SP) neurokinin-1 (NK1) receptors are involved in stress and emotional responses, representing a potential target for the treatment of anxiety and depression in humans. 15845098 2005
CUI: C0011581
Disease: Depressive disorder
Depressive disorder 		0.400 Biomarker disease BEFREE Because of the possible antidepressant effects of SP antagonists, the influence of SP on both pathophysiology and mitigation of depression has been hypothesized. 15157992 2004
CUI: C0011581
Disease: Depressive disorder
Depressive disorder 		0.400 Biomarker disease BEFREE In summary, much more research is needed to elucidate the role of SP in the pathogenesis of depression. 12692775 2003
CUI: C0011581
Disease: Depressive disorder
Depressive disorder 		0.400 Biomarker disease BEFREE This review summarizes the pre-clinical evidence derived from pharmacological and transgenic animal studies that suggests an important role for the substance P/neurokinin 1 system in anxiety and depression. 12907922 2003
CUI: C0011581
Disease: Depressive disorder
Depressive disorder 		0.400 Biomarker disease BEFREE The question is raised whether the present results may be of significance for understanding a possible role of substance P in depression. 10716242 1999