Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Diabetes Mellitus, Non-Insulin-Dependent
0.800 GeneticVariation disease BEFREE Islet ATAC-seq peaks overlap with 13 SNPs associated with T2D (e.g. rs7903146, rs2237897, rs757209, rs11708067 and rs878521 near TCF7L2, KCNQ1, HNF1B, ADCY5 and GCK, respectively) and with additional 67 SNPs in LD with known T2D SNPs (e.g. 31123324 2019
Diabetes Mellitus, Non-Insulin-Dependent
0.800 GeneticVariation disease GWASCAT Identification of 28 new susceptibility loci for type 2 diabetes in the Japanese population. 30718926 2019
Diabetes Mellitus, Non-Insulin-Dependent
0.800 GeneticVariation disease BEFREE Mean C-peptide at diagnosis was higher for HNF4A-MODY than for T1D (1.8 vs 0.9 ng/mL; P < 0.01); 36.4% of patients with HNF4A-MODY and 65.7% of patients with HNF1B-MODY were treated with insulin, whereas 20.5% and 8.6% received oral antidiabetics only (P < 0.05 and P < 0.01 vs T2D). 30535056 2019
Diabetes Mellitus, Non-Insulin-Dependent
0.800 GeneticVariation disease GWASCAT Leveraging Polygenic Functional Enrichment to Improve GWAS Power. 30595370 2019
Diabetes Mellitus, Non-Insulin-Dependent
0.800 GeneticVariation disease BEFREE Mutations in hepatocyte nuclear factor-1β gene result in a multisystemic syndrome where a monogenic form of diabetes (maturity-onset diabetes of young type 5; MODY 5) and renal anomalies, usually bilateral multiple cysts are the most characteristic findings. 29574432 2018
Diabetes Mellitus, Non-Insulin-Dependent
0.800 Biomarker disease BEFREE Here, we outline the effects of genetic and environmental factors on the known phenotypes of MODY, focusing mainly on the examples of MODY 5 and 6, which have low penetrance, as suggestive models for elucidating the multifactorial origin of type 2 diabetes mellitus. 29406598 2018
Diabetes Mellitus, Non-Insulin-Dependent
0.800 GeneticVariation disease GWASCAT Genome-wide association analyses identify 143 risk variants and putative regulatory mechanisms for type 2 diabetes. 30054458 2018
Diabetes Mellitus, Non-Insulin-Dependent
0.800 GeneticVariation disease GWASCAT Identification of new susceptibility loci for type 2 diabetes and shared etiological pathways with coronary heart disease. 28869590 2017
Diabetes Mellitus, Non-Insulin-Dependent
0.800 Biomarker disease BEFREE After adjusting for multiple covariates, SNPs in or near CDKAL1, CDKN2BAS, KCNQ1, TCF7L2, CDC123/CAMK1D, HHEX, and TCF2 were associated with the risk for lean T2D, and SNPs in or near KCNQ1 and FTO were associated with the risk for obese T2D. 27281091 2016
Diabetes Mellitus, Non-Insulin-Dependent
0.800 GeneticVariation disease GWASCAT Genome-wide association studies in the Japanese population identify seven novel loci for type 2 diabetes. 26818947 2016
Diabetes Mellitus, Non-Insulin-Dependent
0.800 GeneticVariation disease BEFREE Common variants in the hepatocyte nuclear factor 1 homeobox B (HNF1B) gene are associated with the risk of Type II diabetes and multiple cancers. 25378557 2015
Diabetes Mellitus, Non-Insulin-Dependent
0.800 AlteredExpression disease BEFREE We have detected the interactions of hsa-miR-214-5p/hsa-miR-550a-5p and the 3'UTR SNP of the HNF1B gene by in vitro luciferase reporter assays, and propose that the binding of such miRNAs regulates the expression of the HNF1B gene and the susceptibility of T2DM. 26329304 2015
Diabetes Mellitus, Non-Insulin-Dependent
0.800 GeneticVariation disease BEFREE Genetic variants of WFS1, CDKAL1, CDKN2BAS, TCF7L2, HHEX, KCNQ1, TSPAN8/LGR5, FTO, and TCF2 were associated with the risk for T2D with MetS, as well as the risk for development of T2D with at least one of the MetS components (P < 0.05). 26599349 2015
Diabetes Mellitus, Non-Insulin-Dependent
0.800 GeneticVariation disease GWASCAT Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility. 24509480 2014
Diabetes Mellitus, Non-Insulin-Dependent
0.800 GeneticVariation disease BEFREE Nominal interactions were observed for sleep duration and PPARG rs1801282, CRY2 rs7943320 and HNF1B rs4430796 in influencing risk of type 2 diabetes (p < 0.05). 24280871 2014
Diabetes Mellitus, Non-Insulin-Dependent
0.800 GeneticVariation disease GWASDB Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility. 24509480 2014
Diabetes Mellitus, Non-Insulin-Dependent
0.800 GeneticVariation disease GWASCAT A genome-wide association study identifies GRK5 and RASGRP1 as type 2 diabetes loci in Chinese Hans. 22961080 2013
Diabetes Mellitus, Non-Insulin-Dependent
0.800 GeneticVariation disease BEFREE We observed consistent and significant associations of IGF2BP2, WFS1, CDKAL1, SLC30A8, CDKN2A/B, HHEX, TCF7L2 and KCNQ1 (8.5×10(-18)<P<8.5×10(-3)), as well as nominal associations of NOTCH2, JAZF1, KCNJ11 and HNF1B (0.05<P<0.1) with T2D risk, which yielded odds ratios ranging from 1.07 to 2.09. 24376643 2013
Diabetes Mellitus, Non-Insulin-Dependent
0.800 GeneticVariation disease GWASDB A genome-wide association study identifies GRK5 and RASGRP1 as type 2 diabetes loci in Chinese Hans. 22961080 2013
Diabetes Mellitus, Non-Insulin-Dependent
0.800 GeneticVariation disease GWASDB Large-scale gene-centric meta-analysis across 39 studies identifies type 2 diabetes loci. 22325160 2012
Diabetes Mellitus, Non-Insulin-Dependent
0.800 GeneticVariation disease GWASCAT Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes. 22885922 2012
Diabetes Mellitus, Non-Insulin-Dependent
0.800 GeneticVariation disease BEFREE Genetic studies revealed a heterozygous mutation (S148L) of the HNF1B gene, compatible with an HNF1B-MODY phenotype (MODY5). 21767339 2012
Diabetes Mellitus, Non-Insulin-Dependent
0.800 GeneticVariation disease BEFREE Our findings suggested that TCF2 variants may be involved in T2D risk in a Han population of northeastern China. 23300827 2012
Diabetes Mellitus, Non-Insulin-Dependent
0.800 GeneticVariation disease GWASDB Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes. 22885922 2012
Diabetes Mellitus, Non-Insulin-Dependent
0.800 Biomarker disease BEFREE hs-CRP was lower in HNF1A-MODY (median [IQR] 0.3 [0.1-0.6] mg/L) than type 2 diabetes (1.40 [0.60-3.45] mg/L; P < 0.001) and type 1 diabetes (1.10 [0.50-1.85] mg/L; P < 0.001), HNF4A-MODY (1.45 [0.46-2.88] mg/L; P < 0.001), GCK-MODY (0.60 [0.30-1.80] mg/L; P < 0.001), and HNF1B-MODY (0.60 [0.10-2.8] mg/L; P = 0.07). hs-CRP discriminated HNF1A-MODY from type 2 diabetes with hs-CRP <0.75 mg/L showing 79% sensitivity and 70% specificity (receiver operating characteristic area under the curve = 0.84). 21700917 2011