Diabetes
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
The combination of a lack of impact of the TCF7L2 genotypes on the ability to lose weight, but the presence of a consistent effect on the proinsulin:insulin ratio over the course of DPP, suggests that high-risk genotype carriers at this locus can successfully lose weight to counter diabetes risk despite persistent deficits in insulin production.
|
21814547 |
2011 |
Diabetes
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Human genetic studies have revealed that the T minor allele of single nucleotide polymorphism rs7903146 in the transcription factor 7-like 2 (TCF7L2) gene is strongly associated with an increased risk of diabetes by 30%-40%.
|
25058603 |
2014 |
Diabetes
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
The TCF7L2 diabetes risk variant is associated with HbA₁(C) levels: a genome-wide association meta-analysis.
|
20849430 |
2010 |
Diabetes
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Single nucleotide polymorphisms (SNPs) in the transcription factor 7-like 2 gene (TCF7L2) represent the strongest and most reproducible genetic associations with diabetes.
|
24128935 |
2013 |
Diabetes
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
The results indicated that the TCF7L2 rs11196172 polymorphism increases the risk of CRC independently, with no evidence of an interaction with diabetes or obesity.
|
27792933 |
2016 |
Diabetes
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Analysis of TCF7L2 rs7903146 in normal controls and diabetics with or without nephropathy demonstrated that the 'T' allele is associated with both diabetes (p = 0.049) and DN (p = 0.024), but this association is not independent of T2DM.
|
25185853 |
2014 |
Diabetes
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
The transcription factor TCF7L2 is particularly strongly associated with risk for diabetes and appears to be fundamentally important in both canonical Wnt signaling and beta-cell functioning.
|
20217507 |
2010 |
Diabetes
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
The aim of the study was to explore the correlation between rs7903146 and rs290487 polymorphisms in transcription factor 7-like 2 (TCF7L2) gene and diabetic nephropathy (DN) in Chinese Han population.Polymerase chain reaction-restriction fragment length polymorphism was used to determine genotypes of TCF7L2 polymorphisms in 90 patients with DN and 96 diabetes patients without DN.
|
30290587 |
2018 |
Diabetes
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Transcription factor 7-like 2 (TCF7L2), which previously known as TCF-4, is a major form of transcription factor involved in the downstream WNT signaling and exhibits the strongest association to diabetes susceptibility.
|
31312258 |
2019 |
Diabetes
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Common variants in TCF7L2 seem to be associated with an increased risk of diabetes among persons with impaired glucose tolerance.
|
16855264 |
2006 |
Diabetes
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Recent human studies suggest transcription factor 7-like 2 (TCF7L2) polymorphism predisposes to diabetes through modulation of beta-cell function and modulates lipid levels in familial dyslipidemia.
|
19105201 |
2009 |
Diabetes
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Maternal GCK and TCF7L2 variants are associated with glucose levels known to carry an increased risk of adverse pregnancy outcome in women without overt diabetes.
|
20682688 |
2010 |
Diabetes
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
These data provide evidence that the beneficial effect of whole-grain intake on diabetes risk is modified by TCF7L2 rs7903146.
|
19149908 |
2009 |
Diabetes
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
There is a trend toward an association between faster GE and the diabetes-associated allele at rs7903146 in TCF7L2.
|
31691451 |
2020 |
Diabetes
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
TCF7L2 genetic variants and progression to diabetes in the Chinese population: pleiotropic effects on insulin secretion and insulin resistance.
|
19806338 |
2010 |
Diabetes
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
TCF7L2 rs7903146 C>T polymorphism is associated with diabetes in the general population but its independent impact on cardiovascular disease is debated.
|
28299838 |
2017 |
Diabetes
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Using gene-network landscape to dissect genotype effects of TCF7L2 genetic variant on diabetes and cardiovascular risk.
|
22872755 |
2012 |
Diabetes
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
In contrast, variants near insulin-like growth factor-binding protein 2 (IGFBP2), CDK5 regulatory subunit associated protein 1-like 1 (CDKAL1), solute carreir family 30 (zinc transporter), member 8 (SLC30A8), hematopoietically-expressed homeobox (HHEX), and transcription factor 7-like2 (TCF7L2) were clearly associated with diabetes; no evidence for an association to CAC was observable.
|
20616309 |
2010 |
Diabetes
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
In addition, the TCF7L2 rs290487 TT genotype was associated with abdominal obesity and the GCG rs12104705 CC genotype was associated with both general obesity and abdominal obesity in case of new-onset diabetes.
|
27998387 |
2016 |
Diabetes
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
After adjusting for known confounding factors, we found a significant association between TCF7L2/rs122555372 and C-peptide (β = -0.76, P = .005) in patients with diabetes and between fasting glucose (β = 2.05, P = .039) and homeostatic model assessment of β-cell function (β = -32.14, P = .025) levels in individuals without diabetes.
|
28101933 |
2017 |
Diabetes
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
The frequency of diabetes-associated TCF7L2 genotypes was greater in cases ascertained for positive family history and early onset (rs4606565, P = 0.02); the population-attributable risk, estimated from the least-selected cases, is approximately 16%.
|
16936215 |
2006 |
Diabetes
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
In subjects without known diabetes (n=961) recruited from the Chennai Urban Rural Epidemiology Study (CURES), OGTT, IDRS, and genotyping of rs12255372 (G/T) and rs7903146(C/T) of TCF7L2 polymorphisms were done.
|
21441683 |
2011 |
Diabetes
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Linagliptin significantly improved hyperglycaemia in patients with type 2 diabetes both with and without the TCF7L2 gene diabetes risk alleles.
|
24906949 |
2014 |
Diabetes
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
TCF7L2 type 2 diabetes susceptibility alleles are associated with islet autoantibody-negative but not autoantibody-positive new onset diabetes in young patients.
|
19050058 |
2009 |
Diabetes
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
In the DESIR cohort, a parental history of diabetes and the TCF7L2 at-risk variant were both associated with hypertension incidence at year 9, independently of waist circumference, BP, fasting glucose, insulin levels and HOMA-IR at inclusion (p = 0.02 for parental history, p = 0.006 for TCF7L2).
|
23942764 |
2013 |