TCF7L2, transcription factor 7 like 2, 6934

N. diseases: 257; N. variants: 70
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0011847
Disease: Diabetes
Diabetes
0.200 GeneticVariation disease BEFREE Common variants in TCF7L2 seem to be associated with an increased risk of diabetes among persons with impaired glucose tolerance. 16855264 2006
CUI: C0011847
Disease: Diabetes
Diabetes
0.200 GeneticVariation disease BEFREE The frequency of diabetes-associated TCF7L2 genotypes was greater in cases ascertained for positive family history and early onset (rs4606565, P = 0.02); the population-attributable risk, estimated from the least-selected cases, is approximately 16%. 16936215 2006
CUI: C0011847
Disease: Diabetes
Diabetes
0.200 GeneticVariation disease BEFREE Effects of the diabetes linked TCF7L2 polymorphism in a representative older population. 17181866 2006
CUI: C0011847
Disease: Diabetes
Diabetes
0.200 Biomarker disease BEFREE Our data indicate for the first time that TCF7L2 gene variants confer an increased risk for early impairment of glucose metabolism in obese children, which is consistent with adult studies identifying TCF7L2 as a major diabetes susceptibility gene. 17311858 2007
CUI: C0011847
Disease: Diabetes
Diabetes
0.200 Biomarker disease BEFREE We have confirmed TCF7L2 to be a diabetes locus in a large case-control study in Tayside, UK. 17429603 2007
CUI: C0011847
Disease: Diabetes
Diabetes
0.200 Biomarker disease BEFREE In the near future, large-scale genome-wide association studies will fully extend the genome coverage, potentially delivering other common diabetes-susceptibility genes like TCF7L2. 17476472 2007
CUI: C0011847
Disease: Diabetes
Diabetes
0.200 GeneticVariation disease BEFREE This study indicates that variants in the TCF7L2 gene significantly contribute to diabetes susceptibility in African-American populations. 17601994 2007
CUI: C0011847
Disease: Diabetes
Diabetes
0.200 AlteredExpression disease BEFREE In this issue of the JCI, Lyssenko and colleagues report on their human and isolated islet studies and suggest that the risk allele increases TCF7L2 expression in the pancreatic beta cell, reducing insulin secretion and hence predisposing the individual to diabetes (see the related article beginning on page 2155). 17671643 2007
CUI: C0011847
Disease: Diabetes
Diabetes
0.200 GeneticVariation disease BEFREE Of 100K SNPs, one (rs7100927) was in moderate LD (r2 = 0.50) with TCF7L2 (rs7903146), and was associated with risk of diabetes (Cox p-value 0.007, additive hazard ratio for diabetes = 1.56) and with tFPG (GEE p-value 0.03). 17903298 2007
CUI: C0011847
Disease: Diabetes
Diabetes
0.200 GeneticVariation disease BEFREE These polymorphisms together with KCNJ11 (Kir6.2)-E23K and TCF7L2-rs7903146 may predict diabetes incidence in the DESIR cohort. 17977958 2008
CUI: C0011847
Disease: Diabetes
Diabetes
0.200 GeneticVariation disease BEFREE We assessed five single nucleotide polymorphisms (SNPs) in TCF7L2 including the putative SNP (rs7903146) for diabetes. 18268068 2008
CUI: C0011847
Disease: Diabetes
Diabetes
0.200 GeneticVariation disease BEFREE We genotyped four single nucleotide polymorphisms (SNPs) of TCF7L2 (rs7901695, rs7903146, rs11196205 and rs12255372) in 831 subjects with diabetes and 437 control subjects. 18291022 2008
CUI: C0011847
Disease: Diabetes
Diabetes
0.200 AlteredExpression disease BEFREE In addition to its recently recognized role in diabetes, aberrant TCF7L2 expression has been implicated in cancer through regulation of cell proliferation and apoptosis by c-MYC and cyclin D. It has been hypothesized that germline variants within the TCF7L2 gene previously associated with diabetes may affect cancer risk through the Wnt/beta-catenin signaling pathway. 18302196 2008
CUI: C0011847
Disease: Diabetes
Diabetes
0.200 Biomarker disease BEFREE LADA shares genetic features with both type 1 (HLA, INS VNTR, and PTPN22) and type 2 (TCF7L2) diabetes, which justifies considering LADA as an admixture of the two major types of diabetes. 18310307 2008
CUI: C0011847
Disease: Diabetes
Diabetes
0.200 Biomarker disease BEFREE Polymorphisms of the transcription factor 7-like 2 (TCF7L2) gene have been associated with insulin sensitivity and diabetes, and the TCF7L2 gene is involved in the Wnt/beta-catenin signaling pathway, all factors thought to be important in the etiology of colon cancer. 18398040 2008
CUI: C0011847
Disease: Diabetes
Diabetes
0.200 GeneticVariation disease BEFREE In conclusion, several population-based samples suggest that variants in the TCF7L2 gene are associated with reduced kidney function or CKD progression, overall and specifically among participants without diabetes. 18650481 2008
CUI: C0011847
Disease: Diabetes
Diabetes
0.200 GeneticVariation disease BEFREE All subjects were genotyped for the previously described TCF7L2 diabetes risk variants. 18702948 2008
CUI: C0011847
Disease: Diabetes
Diabetes
0.200 GeneticVariation disease BEFREE We analysed the recently reported type 2 diabetes (T2D) associated polymorphisms in the TCF7L2 gene using a case-control approach, under the hypothesis that TCF7L2 variants should show similar association if diabetes in FCPD is similar to T2D. 18706099 2008
CUI: C0011847
Disease: Diabetes
Diabetes
0.200 Biomarker disease BEFREE Transcription factor 7-like 2 (TCF7L2) is a gene that is related to the development of diabetes. 18806947 2009
CUI: C0011847
Disease: Diabetes
Diabetes
0.200 GeneticVariation disease BEFREE Our study provides the first significant evidence of association between the TCF7L2 rs7903146 polymorphism and type 2 diabetes risk in a large African American population and also demonstrates that the diabetes risk conveyed by the rs7903146 risk allele is substantially increased in the context of some metabolic risk factors for type 2 diabetes. 18931037 2009
CUI: C0011847
Disease: Diabetes
Diabetes
0.200 GeneticVariation disease BEFREE The population attributable risks for diabetes with TCF7L2 risk alleles were 15 % and with diabetes in a first-degree relative 31 %. 18972257 2009
CUI: C0011847
Disease: Diabetes
Diabetes
0.200 GeneticVariation disease BEFREE TCF7L2 type 2 diabetes susceptibility alleles are associated with islet autoantibody-negative but not autoantibody-positive new onset diabetes in young patients. 19050058 2009
CUI: C0011847
Disease: Diabetes
Diabetes
0.200 GeneticVariation disease BEFREE In this study, we aimed to confirm the effect of the TCF7L2 polymorphism rs7903146 on diabetes risk in a Brazilian population and to assess the use of this genetic marker in improving diabetes risk prediction in the general population. 19055834 2008
CUI: C0011847
Disease: Diabetes
Diabetes
0.200 GeneticVariation disease BEFREE Recent human studies suggest transcription factor 7-like 2 (TCF7L2) polymorphism predisposes to diabetes through modulation of beta-cell function and modulates lipid levels in familial dyslipidemia. 19105201 2009
CUI: C0011847
Disease: Diabetes
Diabetes
0.200 Biomarker disease BEFREE The transcription factor 7-like 2 (TCF7L2) has been recently associated with diabetes risk, and it may exert its effect through metabolic syndrome (MetS)-related traits and be subjected to modification by environmental factors. 19141698 2009