TCF7L2, transcription factor 7 like 2, 6934

N. diseases: 257; N. variants: 70
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0011847
Disease: Diabetes
Diabetes
0.200 GeneticVariation disease BEFREE Associations between TCF7L2 SNP and diabetic complications and diabetes-related factors were investigated. 24529562 2014
CUI: C0011847
Disease: Diabetes
Diabetes
0.200 GeneticVariation disease BEFREE T2D-related variants HHEX rs7923837, TCF7L2 rs290481 and CDKAL1 rs7756992 increased cancer risk in patients with diabetes. 24468095 2014
CUI: C0011847
Disease: Diabetes
Diabetes
0.200 GeneticVariation disease BEFREE Single nucleotide polymorphisms (SNPs) in the transcription factor 7-like 2 gene (TCF7L2) represent the strongest and most reproducible genetic associations with diabetes. 24128935 2013
CUI: C0011847
Disease: Diabetes
Diabetes
0.200 GeneticVariation disease BEFREE In the DESIR cohort, a parental history of diabetes and the TCF7L2 at-risk variant were both associated with hypertension incidence at year 9, independently of waist circumference, BP, fasting glucose, insulin levels and HOMA-IR at inclusion (p = 0.02 for parental history, p = 0.006 for TCF7L2). 23942764 2013
CUI: C0011847
Disease: Diabetes
Diabetes
0.200 GeneticVariation disease BEFREE Using gene-network landscape to dissect genotype effects of TCF7L2 genetic variant on diabetes and cardiovascular risk. 22872755 2012
CUI: C0011847
Disease: Diabetes
Diabetes
0.200 GeneticVariation disease BEFREE Controlling for diabetes status, participants with the TT genotype of TCF7L2 (n= 12) performed worse on tests of attention/executive function/processing speed than those with the CC (n= 46) and CT (n= 53) genotypes, despite no between-group differences in demographic or medical variables. 22712642 2012
CUI: C0011847
Disease: Diabetes
Diabetes
0.200 Biomarker disease BEFREE Findings support an association between TCF7L2 and breast cancer and history of diabetes modifies this association for specific variants. 23085767 2012
CUI: C0011847
Disease: Diabetes
Diabetes
0.200 GeneticVariation disease BEFREE Diabetes-associated variation (T allele at rs7903146) in TCF7L2 may impair the ability of hyperglycemia to suppress glucagon (45 ± 2 vs. 47 ± 2 vs. 60 ± 5 ng/L for CC, CT, and TT, respectively, P = 0.02). 22461567 2012
CUI: C0011847
Disease: Diabetes
Diabetes
0.200 GeneticVariation disease BEFREE This study was conducted to evaluate an association between TCF7L2 variants and diabetes susceptibility in the population of Latvia. 22441719 2012
CUI: C0011847
Disease: Diabetes
Diabetes
0.200 GeneticVariation disease BEFREE The combination of a lack of impact of the TCF7L2 genotypes on the ability to lose weight, but the presence of a consistent effect on the proinsulin:insulin ratio over the course of DPP, suggests that high-risk genotype carriers at this locus can successfully lose weight to counter diabetes risk despite persistent deficits in insulin production. 21814547 2011
CUI: C0011847
Disease: Diabetes
Diabetes
0.200 Biomarker disease BEFREE The TCF7L2 was associated with susceptibility for gestational diabetes independently of the presence of HLA-DQB1*0602 and islet cell autoantibodies and other factors such as maternal age, number of pregnancies, family history of diabetes and other HLA-DQ genotypes. 21672010 2011
CUI: C0011847
Disease: Diabetes
Diabetes
0.200 GeneticVariation disease BEFREE In subjects without known diabetes (n=961) recruited from the Chennai Urban Rural Epidemiology Study (CURES), OGTT, IDRS, and genotyping of rs12255372 (G/T) and rs7903146(C/T) of TCF7L2 polymorphisms were done. 21441683 2011
CUI: C0011847
Disease: Diabetes
Diabetes
0.200 GeneticVariation disease BEFREE Our data suggest that patients with diabetes risk alleles in TCF7L2 have an altered hypoglycaemic response to SUs resulting in earlier secondary failure. 21349175 2011
CUI: C0011847
Disease: Diabetes
Diabetes
0.200 Biomarker disease BEFREE TCF7L2 therefore appears as a genetic link between diabetes and atherosclerosis. 21423583 2011
CUI: C0011847
Disease: Diabetes
Diabetes
0.200 GeneticVariation disease BEFREE The aim of this study was to elucidate which variant in TCF7L2 confers diabetes susceptibility in African Americans. 20980453 2011
CUI: C0011847
Disease: Diabetes
Diabetes
0.200 GeneticVariation disease BEFREE To further determine whether variation in Tcf7l2 expression may lead to diabetes, we developed a Tcf7l2 copy-number allelic series in mice. 21673050 2011
CUI: C0011847
Disease: Diabetes
Diabetes
0.200 Biomarker disease BEFREE TCF7L2 diabetes risk variants, either as single-nucleotide polymorphisms or as haplotypes, detrimentally influence β-cell function and might play a role in determining the metabolic phenotype of patients with newly diagnosed type 2 diabetes. 21159844 2011
CUI: C0011847
Disease: Diabetes
Diabetes
0.200 GeneticVariation disease BEFREE The TCF7L2 diabetes risk variant is associated with HbA₁(C) levels: a genome-wide association meta-analysis. 20849430 2010
CUI: C0011847
Disease: Diabetes
Diabetes
0.200 GeneticVariation disease BEFREE The transcription factor TCF7L2 is particularly strongly associated with risk for diabetes and appears to be fundamentally important in both canonical Wnt signaling and beta-cell functioning. 20217507 2010
CUI: C0011847
Disease: Diabetes
Diabetes
0.200 GeneticVariation disease BEFREE Maternal GCK and TCF7L2 variants are associated with glucose levels known to carry an increased risk of adverse pregnancy outcome in women without overt diabetes. 20682688 2010
CUI: C0011847
Disease: Diabetes
Diabetes
0.200 GeneticVariation disease BEFREE TCF7L2 genetic variants and progression to diabetes in the Chinese population: pleiotropic effects on insulin secretion and insulin resistance. 19806338 2010
CUI: C0011847
Disease: Diabetes
Diabetes
0.200 GeneticVariation disease BEFREE In contrast, variants near insulin-like growth factor-binding protein 2 (IGFBP2), CDK5 regulatory subunit associated protein 1-like 1 (CDKAL1), solute carreir family 30 (zinc transporter), member 8 (SLC30A8), hematopoietically-expressed homeobox (HHEX), and transcription factor 7-like2 (TCF7L2) were clearly associated with diabetes; no evidence for an association to CAC was observable. 20616309 2010
CUI: C0011847
Disease: Diabetes
Diabetes
0.200 GeneticVariation disease BEFREE Thus, diabetes-associated TCF7L2 gene variation predicts the success of lifestyle intervention in terms of weight loss and determines individual susceptibility toward environmental factors. 20028944 2010
CUI: C0011847
Disease: Diabetes
Diabetes
0.200 GeneticVariation disease BEFREE We investigated the association between the TCF7L2 rs7903146 polymorphism and incident IFG defined as fasting serum glucose levels of 100-125 mg/dL (5.6-6.9 mmol/L) in 1377 African American and 5152 Caucasian participants without diabetes and IFG at intake who participated in the Atherosclerosis Risk in Communities (ARIC) Study from 1987 to 1989 and were followed for 9 years. 20578204 2010
CUI: C0011847
Disease: Diabetes
Diabetes
0.200 Biomarker disease BEFREE These findings suggest that TCF7L2 is a central node in the regulation of human diabetes and other disease-associated genes. 20640398 2010