TCF7L2, transcription factor 7 like 2, 6934

N. diseases: 257; N. variants: 70
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0003850
Disease: Arteriosclerosis
Arteriosclerosis
0.070 Biomarker disease BEFREE TCF7L2 therefore appears as a genetic link between diabetes and atherosclerosis. 21423583 2011
CUI: C0003850
Disease: Arteriosclerosis
Arteriosclerosis
0.070 GeneticVariation disease BEFREE We evaluated associations in the Atherosclerosis Risk in Communities study between PrCa and nine T2D single nucleotide polymorphisms from genome-wide association studies of T2D (in CDKAL1, CDKN2A/B, FTO, HHEX, IGF2BP2, KCNJ11, PPARG, SLC30A8, and TCF7L2) and four T2D single nucleotide polymorphisms from pre-genome-wide association studies (in ADRB2, CAPN10, SLC2A2, and UCP2). 20142250 2010
CUI: C0003850
Disease: Arteriosclerosis
Arteriosclerosis
0.070 GeneticVariation disease BEFREE We investigated the association between the TCF7L2 rs7903146 polymorphism and incident IFG defined as fasting serum glucose levels of 100-125 mg/dL (5.6-6.9 mmol/L) in 1377 African American and 5152 Caucasian participants without diabetes and IFG at intake who participated in the Atherosclerosis Risk in Communities (ARIC) Study from 1987 to 1989 and were followed for 9 years. 20578204 2010
CUI: C0003850
Disease: Arteriosclerosis
Arteriosclerosis
0.070 GeneticVariation disease BEFREE We investigated the association between the TCF7L2 rs7903146 polymorphism and type 2 diabetes in 2,727 African American and 9,302 Caucasian participants without diabetes who were inducted into the Atherosclerosis Risk in Communities study in 1987-1989 and followed for 9 years. 18931037 2009
CUI: C0003850
Disease: Arteriosclerosis
Arteriosclerosis
0.070 GeneticVariation disease BEFREE TCF7L2 single nucleotide polymorphisms, cardiovascular disease and all-cause mortality: the Atherosclerosis Risk in Communities (ARIC) study. 18437354 2008
CUI: C0003850
Disease: Arteriosclerosis
Arteriosclerosis
0.070 GeneticVariation disease BEFREE Participants of the Atherosclerosis Risk in Communities Study (ARIC; n = 11,061 self-identified white and n = 4014 black), Framingham Heart Offspring Cohort (FHS; n = 2468), and Heredity and Phenotype Intervention Heart Study (HAPI; n = 861) were genotyped at five (ARIC) and two (FHS) common TCF7L2 variants. 18650481 2008
CUI: C0003850
Disease: Arteriosclerosis
Arteriosclerosis
0.070 GeneticVariation disease BEFREE Variation in TCF7L2 and increased risk of colon cancer: the Atherosclerosis Risk in Communities (ARIC) Study. 18268068 2008