|
Malignant neoplasm of breast
|
0.200 |
Biomarker
|
disease |
BEFREE |
Long non-coding RNA LUCAT1/miR-5582-3p/TCF7L2 axis regulates breast cancer stemness via Wnt/β-catenin pathway.
|
31300015 |
2019 |
|
Malignant neoplasm of breast
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Additionally, the tag polymorphisms in TCF7L2 are associated with the clinical features of breast cancer, which may provide us novel insight into the pathogenesis of breast cancer.
|
27738320 |
2016 |
|
Malignant neoplasm of breast
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Three T2D associated risk variants were individually associated with breast cancer risk after adjustment for multiple comparisons using the Bonferroni method (at p < 0.001), rs9939609 (FTO) (OR 0.94, 95 % CI = 0.92-0.95, p = 4.13E-13), rs7903146 (TCF7L2) (OR 1.04, 95 % CI = 1.02-1.06, p = 1.26E-05), and rs8042680 (PRC1) (OR 0.97, 95 % CI = 0.95-0.99, p = 8.05E-04).
|
27053251 |
2016 |
|
Malignant neoplasm of breast
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Overall, TCF7L2 gene polymorphisms were significantly associated with an increased risk of breast cancer in genetic comparison models (rs12255372 for GG vs GT: OR = 0.90, 95%CI = 0.83-0.98; rs7903146 for CC vs TT: OR = 0.75, 95%CI = 0.63-0.90, CC vs CT: OR = 0.88, 95%CI = 0.81-0.97, dominant model: OR = 1.16, 95%CI = 1.06-1.27, recessive model: OR = 0.79, 95%CI = 0.67-0.94).
|
25867435 |
2015 |
|
Malignant neoplasm of breast
|
0.200 |
Biomarker
|
disease |
BEFREE |
HS3ST2 modulates breast cancer cell invasiveness via MAP kinase- and Tcf4 (Tcf7l2)-dependent regulation of protease and cadherin expression.
|
24752740 |
2014 |
|
Malignant neoplasm of breast
|
0.200 |
GeneticVariation
|
disease |
GWASDB |
Large-scale genotyping identifies 41 new loci associated with breast cancer risk.
|
23535729 |
2013 |
|
Malignant neoplasm of breast
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
The results showed that TCF7L2 polymorphism was associated with breast cancer (Homogeneous model: OR=1.17, 95%CI=1.02-1.35, I (2) =21.8%, p for heterogeneity=0.276; Heterogeneous model: OR=1.11, 95%CI=1.03-1.20, I (2) =0.0%, p for heterogeneity=0.543), prostate cancer (Homogeneous model: OR=0.89, 95%CI=0.84-0.96, I (2) =0.0%, p for heterogeneity=0.640; Heterogeneous model: OR=0.89, 95%CI=0.84-0.95, I (2) =0.0%, p for heterogeneity=0.871), and colon cancer (Heterogeneous model: OR=1.15, 95%CI=1.01-1.31, I (2) =0.0%, p for heterogeneity=0.658), but not with colorectal cancer, lung cancer, and ovarian cancer.
|
23951231 |
2013 |
|
Malignant neoplasm of breast
|
0.200 |
AlteredExpression
|
disease |
BEFREE |
Consistently, SOX9 overexpression in BCa cell lines and transgenic SOX9 expression in breast epithelium caused increased LRP6 and TCF4 expression and Wnt/β-catenin activation.
|
23306204 |
2013 |
|
Malignant neoplasm of breast
|
0.200 |
Biomarker
|
disease |
BEFREE |
Genotypic analysis of individual locus showed statistically significant association of five SNPs located in β-catenin, AXIN2, DKK3, SFRP3 and TCF7L2 with breast cancers.
|
23516639 |
2013 |
|
Malignant neoplasm of breast
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Our results confirmed the association of rs7014346 in POU5F1P1, rs989902 in PTPN13, and rs7003146 in TCF7L2 with variations in the risk of breast cancer in a Chinese Han population.
|
24338422 |
2013 |
|
Malignant neoplasm of breast
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Studies on the association between the TCF7L2 rs12255372 polymorphism and breast cancer risk have reported conflicting results.
|
24266846 |
2013 |
|
Malignant neoplasm of breast
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
After adjusting for multiple comparisons, four TCF7L2 SNPs were significantly associated with breast cancer overall: rs7903146 (OR(TT) 1.24; 95 % CI 1.03-1.49), rs3750805 (OR(AT/TT) 1.15; 95 % CI 1.03-1.28), rs7900150 (OR(AA) 1.23; 95 % 1.07-1.42), and rs1225404 (OR(CC) 0.82; 95 % 0.70-0.94).
|
23085767 |
2012 |
|
Malignant neoplasm of breast
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Genetic variations in transcription factor 7-like 2 (TCF7L2) gene: association of TCF7L2 rs12255372(G/T) or rs7903146(C/T) with breast cancer risk and clinico-pathological parameters.
|
21301999 |
2012 |
|
Malignant neoplasm of breast
|
0.200 |
AlteredExpression
|
disease |
BEFREE |
These findings indicate that the MUC1-C oncoprotein contributes to TCF7L2 activation and thereby promotes cyclin D1 expression in breast cancer cells.
|
22318732 |
2012 |
|
Malignant neoplasm of breast
|
0.200 |
Biomarker
|
disease |
BEFREE |
Similar effects were observed in MDA-MB-231 and MDA-MB-435s human breast cancer cell lines exposed to (-)-agelastatin A. Suppression of Tcf-4 by RNA interference (short interfering RNA) induced malignant/invasive transformation in parental benign Rama 37 cells; significantly, these events were reversed by treatment with (-)-agelastatin A.
|
18347142 |
2008 |
|
Malignant neoplasm of breast
|
0.200 |
Biomarker
|
disease |
BEFREE |
In a rat model for breast cancer it has been shown that metastasis-inducing DNA (Met-DNA) sequesters the endogenous inhibitory Tcf-4 and thereby promotes transcription of the secreted extracellular matrix glycophosphoprotein, osteopontin, the direct effector of metastasis in this model system.
|
18289012 |
2008 |