Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0011847
Disease: Diabetes
Diabetes
0.100 GeneticVariation disease BEFREE TCF7L2 rs7903146 C>T polymorphism is associated with diabetes in the general population but its independent impact on cardiovascular disease is debated. 28299838 2018
CUI: C0011847
Disease: Diabetes
Diabetes
0.100 Biomarker disease BEFREE TCF7L2 Genotype and α-Cell Function in Humans Without Diabetes. 26525881 2016
CUI: C0011847
Disease: Diabetes
Diabetes
0.100 AlteredExpression disease BEFREE TCF7L2 is a transcription factor in the canonical Wnt pathway, involved in multiple disorders, including diabetes, cancer and psychiatric conditions. 26934194 2016
CUI: C0011847
Disease: Diabetes
Diabetes
0.100 GeneticVariation disease BEFREE Association between the rs7903146 Polymorphism in the TCF7L2 Gene and Parameters Derived with Continuous Glucose Monitoring in Individuals without Diabetes. 26914832 2016
CUI: C0011847
Disease: Diabetes
Diabetes
0.100 GeneticVariation disease BEFREE Human genetic studies have revealed that the T minor allele of single nucleotide polymorphism rs7903146 in the transcription factor 7-like 2 (TCF7L2) gene is strongly associated with an increased risk of diabetes by 30%-40%. 25058603 2015
CUI: C0011847
Disease: Diabetes
Diabetes
0.100 GeneticVariation disease BEFREE Linagliptin significantly improved hyperglycaemia in patients with type 2 diabetes both with and without the TCF7L2 gene diabetes risk alleles. 24906949 2015
CUI: C0011847
Disease: Diabetes
Diabetes
0.100 GeneticVariation disease BEFREE Associations between TCF7L2 SNP and diabetic complications and diabetes-related factors were investigated. 24529562 2014
CUI: C0011847
Disease: Diabetes
Diabetes
0.100 GeneticVariation disease BEFREE T2D-related variants HHEX rs7923837, TCF7L2 rs290481 and CDKAL1 rs7756992 increased cancer risk in patients with diabetes. 24468095 2014
CUI: C0011847
Disease: Diabetes
Diabetes
0.100 GeneticVariation disease BEFREE In the DESIR cohort, a parental history of diabetes and the TCF7L2 at-risk variant were both associated with hypertension incidence at year 9, independently of waist circumference, BP, fasting glucose, insulin levels and HOMA-IR at inclusion (p = 0.02 for parental history, p = 0.006 for TCF7L2). 23942764 2014
CUI: C0011847
Disease: Diabetes
Diabetes
0.100 GeneticVariation disease BEFREE Impact of TCF7L2 single nucleotide polymorphisms on hydrochlorothiazide-induced diabetes. 24128935 2014
CUI: C0011847
Disease: Diabetes
Diabetes
0.100 GeneticVariation disease BEFREE After adjustment for age and ethnicity, the TCF7L2 rs7903146 and the FTO rs8050136 variants significantly predicted postpartum diabetes; hazard ratio (95% confidence interval 1.29 (1.01-1.66) and 1.36 (1.06-1.74), respectively (additive model) versus 1.45 (1.01-2.08) and 1.56 (1.06-2.29) (dominant model)). 22591707 2013
CUI: C0011847
Disease: Diabetes
Diabetes
0.100 GeneticVariation disease BEFREE Additionally, risk variants rs9939609 of FTO, rs2796441 of TLE1, rs560887 of G6PC2, rs780094 of GCKR, rs7903146 of TCF7L2 and rs11708067 of ADCY5 showed nominally significant associations with GDM (OR range from 1.25 to 1.30). 23761423 2013
CUI: C0011847
Disease: Diabetes
Diabetes
0.100 Biomarker disease BEFREE Findings support an association between TCF7L2 and breast cancer and history of diabetes modifies this association for specific variants. 23085767 2013
CUI: C0011847
Disease: Diabetes
Diabetes
0.100 GeneticVariation disease BEFREE Using gene-network landscape to dissect genotype effects of TCF7L2 genetic variant on diabetes and cardiovascular risk. 22872755 2013
CUI: C0011847
Disease: Diabetes
Diabetes
0.100 AlteredExpression disease BEFREE The expression of transcription factor 7-like 2 (TCF7L2) in fat and placental tissue from women with gestational diabetes. 21855162 2012
CUI: C0011847
Disease: Diabetes
Diabetes
0.100 GeneticVariation disease BEFREE Diabetes-associated variation (T allele at rs7903146) in TCF7L2 may impair the ability of hyperglycemia to suppress glucagon (45 ± 2 vs. 47 ± 2 vs. 60 ± 5 ng/L for CC, CT, and TT, respectively, P = 0.02). 22461567 2012
CUI: C0011847
Disease: Diabetes
Diabetes
0.100 GeneticVariation disease BEFREE To further determine whether variation in Tcf7l2 expression may lead to diabetes, we developed a Tcf7l2 copy-number allelic series in mice. 21673050 2012
CUI: C0011847
Disease: Diabetes
Diabetes
0.100 Biomarker disease BEFREE The TCF7L2 was associated with susceptibility for gestational diabetes independently of the presence of HLA-DQB1*0602 and islet cell autoantibodies and other factors such as maternal age, number of pregnancies, family history of diabetes and other HLA-DQ genotypes. 21672010 2011
CUI: C0011847
Disease: Diabetes
Diabetes
0.100 GeneticVariation disease BEFREE TCF7L2 polymorphism, weight loss and proinsulin:insulin ratio in the diabetes prevention program. 21814547 2011
CUI: C0011847
Disease: Diabetes
Diabetes
0.100 Biomarker disease BEFREE TCF7L2 therefore appears as a genetic link between diabetes and atherosclerosis. 21423583 2011
CUI: C0011847
Disease: Diabetes
Diabetes
0.100 Biomarker disease BEFREE TCF7L2 diabetes risk variants, either as single-nucleotide polymorphisms or as haplotypes, detrimentally influence β-cell function and might play a role in determining the metabolic phenotype of patients with newly diagnosed type 2 diabetes. 21159844 2011
CUI: C0011847
Disease: Diabetes
Diabetes
0.100 GeneticVariation disease BEFREE Resequencing and analysis of variation in the TCF7L2 gene in African Americans suggests that SNP rs7903146 is the causal diabetes susceptibility variant. 20980453 2011
CUI: C0011847
Disease: Diabetes
Diabetes
0.100 Biomarker disease BEFREE These findings suggest that TCF7L2 is a central node in the regulation of human diabetes and other disease-associated genes. 20640398 2011
CUI: C0011847
Disease: Diabetes
Diabetes
0.100 GeneticVariation disease BEFREE In the family-based study, variation in TCF7L2 increased the risk of diabetes about three-fold (HR 1.75 per allele, 95% CI 1.3-2.4; p = 0.0006), and decreased the mean age at diabetes diagnosis by 7 years. 19585101 2010
CUI: C0011847
Disease: Diabetes
Diabetes
0.100 GeneticVariation disease BEFREE TCF7L2 genetic variants and progression to diabetes in the Chinese population: pleiotropic effects on insulin secretion and insulin resistance. 19806338 2010