TCF7L2, transcription factor 7 like 2, 6934

N. diseases: 257; N. variants: 70
Disease: Hyperglycemia ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0020456
Disease: Hyperglycemia
Hyperglycemia 		0.100 GeneticVariation disease BEFREE Also the well-known gene variants rs7903146 in TCF7L2, and rs17817449 in FTO, were nominally associated with hyperglycemia (rs7903146), as well as with higher fasting insulin levels (rs17817449). 30063936 2018
CUI: C0020456
Disease: Hyperglycemia
Hyperglycemia 		0.100 Biomarker disease BEFREE Type 2 diabetes mellitus susceptibility gene TCF7L2 is strongly associated with hyperglycemia in the Saudi Arabia Population of the eastern province of Saudi Arabia. 26367734 2015
CUI: C0020456
Disease: Hyperglycemia
Hyperglycemia 		0.100 GeneticVariation disease BEFREE Linagliptin significantly improved hyperglycaemia in patients with type 2 diabetes both with and without the TCF7L2 gene diabetes risk alleles. 24906949 2014
CUI: C0020456
Disease: Hyperglycemia
Hyperglycemia 		0.100 AlteredExpression disease BEFREE Our study shows that the short TCF7L2 mRNA variant in subcutaneous fat is regulated by weight loss and is associated with hyperglycemia and impaired insulin action in adipose tissue. 23086040 2012
CUI: C0020456
Disease: Hyperglycemia
Hyperglycemia 		0.100 AlteredExpression disease BEFREE Collectively, these data suggest a crucial role of TCF7L2 in hepatic glucose metabolism; reduced hepatic expression of nuclear isoforms of this factor might be a critical instigator of hyperglycemia in type 2 diabetes. 23028378 2012
CUI: C0020456
Disease: Hyperglycemia
Hyperglycemia 		0.100 GeneticVariation disease BEFREE Diabetes-associated variation (T allele at rs7903146) in TCF7L2 may impair the ability of hyperglycemia to suppress glucagon (45 ± 2 vs. 47 ± 2 vs. 60 ± 5 ng/L for CC, CT, and TT, respectively, P = 0.02). 22461567 2012
CUI: C0020456
Disease: Hyperglycemia
Hyperglycemia 		0.100 GeneticVariation disease BEFREE The T-allele of TCF7L2 rs7903146 polymorphism was independently associated with increasing fasting glucose values toward hyperglycemia in the follow-up. 20299486 2010
CUI: C0020456
Disease: Hyperglycemia
Hyperglycemia 		0.100 GeneticVariation disease BEFREE Hyperglycemia and Adverse Pregnancy Outcome (HAPO) study: common genetic variants in GCK and TCF7L2 are associated with fasting and postchallenge glucose levels in pregnancy and with the new consensus definition of gestational diabetes mellitus from the International Association of Diabetes and Pregnancy Study Groups. 20682688 2010
CUI: C0020456
Disease: Hyperglycemia
Hyperglycemia 		0.100 GeneticVariation disease BEFREE Polymorphisms in TCF7L2 (rs7903146, OR 1.10, 95% CI 1.04-1.17, p = 0.00097), FTO (rs9939609, OR 1.08, 95% CI 1.02-1.14, p = 0.0065), WFS1 (rs10010131, OR 1.07, 95% CI 1.02-1.13, p = 0.0078) and IGF2BP2 (rs4402960, OR 1.07, 95% CI 1.01-1.13, p = 0.021) predicted the development of at least three components of the metabolic syndrome in both univariate and multivariate analysis; in the case of TCF7L2, WFS1 and IGF2BP this was due to their association with hyperglycaemia (p < 0.00001, p = 0.0033 and p = 0.027, respectively) and for FTO it was due to its association with obesity (p = 0.004). 18853134 2008
CUI: C0020456
Disease: Hyperglycemia
Hyperglycemia 		0.100 GeneticVariation disease LHGDN We conclude that the TCF7L2 T at-risk allele variation (rs7903146) predicts hyperglycemia incidence in a general French population, possibly through a deleterious effect on insulin secretion. 17065361 2006
CUI: C0020456
Disease: Hyperglycemia
Hyperglycemia 		0.100 GeneticVariation disease BEFREE We conclude that the TCF7L2 T at-risk allele variation (rs7903146) predicts hyperglycemia incidence in a general French population, possibly through a deleterious effect on insulin secretion. 17065361 2006