TCF7L2, transcription factor 7 like 2, 6934

N. diseases: 257; N. variants: 70
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.460 Biomarker disease BEFREE For instance, transcription factor 7-like 2 (TCF7L2) and proteasome 26S subunit, non-ATPase 9 (PSMD9) are two genes independently reported as contributing to T2D and SCZ, and PSMD9 to MDD as well. 30729689 2019
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.460 GeneticVariation disease GWASCAT Evidence for genetic contribution to the increased risk of type 2 diabetes in schizophrenia. 30470734 2018
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.460 Biomarker disease BEFREE Recently, growing evidence suggests that Wnt signaling pathway has a critical role in the pathogenesis of schizophrenia and molecular cascades of antipsychotics action, of which Wnt signaling pathway key effector TCF7L2 is strongly associated with glucose homeostasis. 29713286 2018
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.460 GeneticVariation disease BEFREE We examined the association between TCF7L2 polymorphisms and SCZ susceptibility in a Chinese Han population. 28404897 2017
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.460 Biomarker disease BEFREE These preliminary results independently support previous findings regarding a possible role of TCF7L2 in susceptibility to schizophrenia, and strengthen the importance of integrating linkage analysis models of inheritance while performing association analyses in regions of interest. 22247771 2012
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.460 Biomarker disease PSYGENET These preliminary results independently support previous findings regarding a possible role of TCF7L2 in susceptibility to schizophrenia, and strengthen the importance of integrating linkage analysis models of inheritance while performing association analyses in regions of interest. 22247771 2012
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.460 GeneticVariation disease BEFREE One type II diabetes at-risk allele located in TCF7L2, rs7903146 [T], was associated with schizophrenia in the discovery sample (p = .0052) and in the replication with an odds ratio of 1.07 (95% confidence interval 1.01-1.14, p = .033). 21414605 2011
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.460 Biomarker disease PSYGENET One type II diabetes at-risk allele located in TCF7L2, rs7903146 [T], was associated with schizophrenia in the discovery sample (p = .0052) and in the replication with an odds ratio of 1.07 (95% confidence interval 1.01-1.14, p = .033). 21414605 2011
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.460 Biomarker disease PSYGENET In support of shared genetic burdens, TCF7L2, the strongest genetic determinant for T2D risk in the human population, has been recently implicated in schizophrenia (SCZ) risk, suggesting that this may be one of many loci that pleiotropically influence both diseases. 22046400 2011
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.460 Biomarker disease PSYGENET We conclude TCF7L2, a risk factor for T2D in the general population, is also a risk factor for T2D in African-American patients with SCZ or schizoaffective disorder. 19643578 2009
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.460 Biomarker disease BEFREE We conclude TCF7L2, a risk factor for T2D in the general population, is also a risk factor for T2D in African-American patients with SCZ or schizoaffective disorder. 19643578 2009